【Animal Modeling】-Analysis of the effects of different hypoxia exposure modes on differential gene expression of rat tibialis anterior muscle based on RNA sequencing

To screen the differentially expressed genes and their related pathways in rat tibialis anterior muscle from chronic intermittent hypoxia exposure and acute hypoxia exposure...

2022-09-24

【Animal modeling】-Based on autophagy to investigate the effect of fentanyl combined with propofol on cardiac ischemia-reperfusion injury in rats

To investigate the effect of fentanyl combined with propofol on cardiac ischemia-reperfusion injury in rats based on autophagy...

2022-09-24

【Animal Modeling】-Effect and mechanism of different styles of music on the behavior of CUMS-depressed rats

o establish a depression model in SD rats through chronic mild and unpredictable stimulation, and to preliminarily explore the effect and mechanism of different styles of music on improving depression-like behavior in SD rats...

2022-09-24

【Animal Modeling】-Mechanism of Xishutongshuan Capsules attenuating cognitive impairment in rats with chronic cerebral ischemia

To study the effect of Xishuntongshuan Capsule on the rat model of chronic cerebral ischemia and its influence on the blood-brain barrier...

2022-09-24

【Animal Modeling】-Establishment of a mouse model of IgA nephropathy induced by superantigen Staphylococcus enterotoxin B

To establish a mouse model of IgA nephropathy, and to observe the biochemical and pathological characteristics of the model...

2022-09-24

【Animal modeling】-FGF-2/PELA/BMP-2 microcapsule scaffold promotes the osteogenic differentiation of rat periosteum-derived stem cells

To observe the effect of fibroblast growth factor-2/polylactic acid-polyethylene glycol-polylactic acid/bone morphogenetic protein-2 (FGF-2/PELA/BMP-2) microcapsule scaffold on the formation of periosteum-derived stem cells in SD rats. Bone different...

2022-09-23

【Animal modeling】-Mechanism of recombinant adenovirus-mediated adiponectin gene on atherosclerosis in ApoE-/- mice

To study the inhibitory effect of adenovirus-mediated adiponectin (APN) overexpression on atherosclerosis (AS) in ApoE-/- mice and its effect on NF-κB signaling pathway...

2022-09-23

【Animal Modeling】-Comparison of three methods of tracheal infusion of bleomycin to induce pulmonary fibrosis in mice

To inject bleomycin into C57BL/6J mice to induce pulmonary fibrosis by three different methods: lumbar puncture tracheal intubation, indwelling needle tracheal intubation and tracheotomy, and to explore the modeling of lumbar puncture tracheal intuba...

2022-09-23

【Animal Modeling】-Research on the analgesic effects of Lugai Qishan Fluoxane on labor and delivery based on MAPK signaling hypoxia

To investigate the effect of sevoflurane labor analgesia on hypoxia in neonatal rats based on the mitogen-activated protein kinase signaling pathway...

2022-09-23

【Animal modeling】-Protective effect of trigonelline on testicular injury induced by heat stress in mice

To study the protective effect of trigonelline on heat stress-induced testicular injury in mice...

2022-09-23

【Animal Modeling】-Minocycline inhibits the hyperpolarization-activated current of glial neurons in the dorsal horn of rat spinal cord

To study the effect of minocycline on the hyperpolarization-activated current (Ih) of colloidal (SG) neurons in the spinal dorsal horn of rats...

2022-09-22

【Animal modeling】-The effect of long-term consumption of Polygonum multiflorum on the hematopoietic system of mice

To investigate the changes of mouse hematopoietic system after long-term consumption of Polygonum multiflorum...

2022-09-22

【Animal modeling】-The acute toxicity of CKLF1-C19 to Kunming mice

To study the acute toxicity of the polypeptide CKLF1-C19 of chemokine-like factor 1 (CKLF1) on Kunming mice...

2022-09-22

USC Scientists Use TRAP Technology to Capture Early Signs of Acute Kidney Injury in Mice

Recently, USC stem cell scientists have successfully set up a mouse that captures acute kidney injury disease signals, using this TRAP mouse to capture early signs of kidney failure, the description was published in the Journal of Clinical Investigat...

2022-09-21

【Animal Modeling】-Animal Model of Sclerosing Glomerulonephropathy

Sclerosing glomerulonephritis is the end stage of many types of glomerulonephritis, rather than an independent pathological type of glomerulonephritis. The pathological changes are characterized by extensive glomerulosclerosis, renal tubular atrophy...

2022-09-21

【Animal Model】-Effect of X-ray whole body irradiation on the function of hematopoietic immune system in KKAy mice with type 2 diabetes

To observe the damage effect of X-ray whole body irradiation on the function of hematopoietic immune system in KKAy mice, a model of type 2 diabetes mellitus, and compare it with control C57 mice...

2022-09-21