【Animal modeling】-Protective effect of curcumin on acute kidney injury in pregnant hypertensive rats

To investigate the protective effect of curcumin on acute kidney injury induced by gestational hypertension in rats and explore its potential mechanism...

2022-06-22

【Animal Modeling】-Experimental Study on Lung Tissue Injury Induced by Dental Grinding Dust in Rats

To evaluate the effects of three kinds of dental grinding dusts of cobalt-chromium-molybdenum metal (trade name: Vitaline), zirconium dioxide porcelain and polymethyl methacrylate resin on lung tissue injury in rats...

2022-06-22

【Animal modeling】-Effect of Naoshuantong capsule on the expression of inflammatory factors in aorta of ApoE-/- mice

To observe the effect of Naoshuantong capsule on the expression of inflammatory related factors interleukin-1β, interleukin-6, tumor necrosis factor, intercellular adhesion molecule-1 and metalloproteinase-9 in ApoE-/- atherosclerosis mouse model. Th...

2022-06-22

【Animal Modeling】-Establish a safe and effective method for obtaining liver and kidney samples by in vivo puncture of rhesus monkeys under the guidance of B-ultrasound

To analyze the variation trends and gender differences of organ coefficient, intestinal length and body size in SJ5-SPF chickens of different ages, and to provide experimental data for the sex selection of experimental animals...

2022-06-21

【Animal modeling】-Effect of curcumin on glucose transport and PI3K/Akt signaling pathway in adipocytes of type 2 diabetic rats

To investigate the effect of curcumin on glucose transport and phosphatidylinositol kinase-3 (PI3K)/protein kinase B (Akt) signaling pathway in adipocytes of type 2 diabetes mellitus (T2DM) rats...

2022-06-21

【Animal Modeling】-Discussion on the Differences in Blood Indexes of Young SD Rats at Different Stages

The purpose of this study was to collect blood indexes of young SD rats at different developmental stages, establish corresponding background data, and provide reference for the evaluation of pediatric drug safety...

2022-06-21

【Animal Modeling】-Changes and Significance of Arterial Blood Gas Analysis in Rats with Chronic Hypoxic Pulmonary Hypertension

To investigate the changes and significance of arterial blood gas analysis indexes in a rat model of hypoxic pulmonary hypertension induced by chronic hypoxia...

2022-06-21

【Animal Modeling】-FoxO3A Gene Knockout Mice Breeding Identification and Primary Analysis of Bone Marrow Hematopoietic Stem Cell Phenotype

To breed and identify FOXO3A knockout mice. The selected FOXO3A knockout heterozygous mice were used for breeding, and the homozygous mice were used for experiments...

2022-06-21

【Animal Modeling】-Expression of Perilipin in Kidney Tissue of Rats with Diabetic Nephropathy

To observe the characteristics of rat diabetic nephropathy model and the diagnostic value of urinary LN for early DN, and to explore the expression of perilipin (Plin) in the kidneys of DN rats...

2022-06-21

【Animal Modeling】-Establishment and application of real-time PCR detection method for mouse cytomegalovirus

To establish a fluorescent quantitative PCR method for mouse cytomegalovirus and make a preliminary application...

2022-06-21

【Animal modeling】-The role of villin 1 in unilateral nephrectomy Habu nephritis mouse model

To investigate the similarities and differences between unilateral nephrectomy (UNX) mouse Habu nephritis model and normal mouse Habu nephritis model in renal function, renal pathological manifestations and glomerular villin 1 (VIL 1) expression and ...

2022-06-20

【Animal modeling】-Effect of salidroside on Nrf2/Keap1 signaling pathway and wound healing in diabetic foot ulcer rats

To investigate the effect of salidroside (Sal) on nuclear transcription factor E2-related factor 2 / Kelch-like epichlorohydrin-related protein 1 (Nrf2 / Keap1) signaling pathway and wound healing in diabetic foot ulcer (DFU) rats...

2022-06-20

【Animal modeling】-Intervention effect and mechanism of Exendin-4 on STZ-induced diabetic nephropathy in rats

To study the intervention effect and possible mechanism of Exendin-4 on streptozotocin-induced diabetic nephropathy in rats...

2022-06-20

【Animal Modeling】-Research on the analgesic effects of Lugai Qishan Fluoxane on labor and delivery based on MAPK signaling hypoxia

To investigate the effect of sevoflurane labor analgesia on hypoxia in neonatal rats based on the mitogen-activated protein kinase (MAPK) signaling pathway...

2022-06-20

【Animal Modeling】-Safflower Yellow Pigment Protects the Kidneys of Mice with Diabetic Nephropathy and Its Mechanism

To investigate the renal protective effect and mechanism of safflower yellow on streptozotocin-induced diabetic nephropathy in mice...

2022-06-20

【Animal modeling】-Protective effect of oxymatrine on atopic dermatitis model mice

To investigate the efficacy and preliminary mechanism of oxymatrine, the active ingredient in Sophora flavescens, in the treatment of atopic dermatitis mice...

2022-06-17