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【Animal Modeling】-Intravenous injection of mercuric chloride nephropathy model

【Animal Modeling】-Intravenous injection of mercuric chloride nephropathy model

Replication method For adult male mice weighing 25 to 30 g, HgCl2 was prepared into 0.125 g/L Hg2 + solution and physiological saline, and then HgCl2 ml/kg body weight was injected from the tail vein of the mouse at a dose of 10 (the dose was about L...

2021-03-26
【Animal Modeling】-Bronchi Asthma Transgenic Animal Model

【Animal Modeling】-Bronchi Asthma Transgenic Animal Model

The replication method mainly uses transgene or gene knockout technology to study the role of changes in specific gene expression products in the development of asthma...

2021-03-25
[Animal Modeling]-Guinea Pig Bronchial Asthma Animal Model

[Animal Modeling]-Guinea Pig Bronchial Asthma Animal Model

After 5 to 7 days of adaptive reproduction of adult guinea pigs, 10% ovalbumin saline was injected intraperitoneally at a weight of 200 mg/kg and inhaled intraperitoneally on the 15th day...

2021-03-25
【Animal Modeling】-Animal Model of Chronic Bronchitis

【Animal Modeling】-Animal Model of Chronic Bronchitis

In the modeling experiment, mice are placed in a 10 L lower mouth bottle, a 1.5 cm diameter vent hole is left on the cap, the lower mouth is connected to the tee, and the other end is connected...

2021-03-25
【Animal Modeling】-Smoking Animal Model

【Animal Modeling】-Smoking Animal Model

During the experiment, the experimental rats (male and female) were placed in a fume hood, and the cabinet was exposed to smoke (twice a day, 16 cigarettes/hour per day) and smoke concentration, and controlled...

2021-03-25
【Animal Modeling】-Canine Intraperitoneal Injection of Fecal Filtrate and Abdominal Infection Model

【Animal Modeling】-Canine Intraperitoneal Injection of Fecal Filtrate and Abdominal Infection Model

Anesthetize healthy adult dogs by intraperitoneal injection of sodium pentobarbital with a body weight of 40 mg/kg...

2021-03-25
【Animal Modeling】-Sepsis Rabbit Model

【Animal Modeling】-Sepsis Rabbit Model

Breeding method After local anesthesia with procaine, a New Zealand adult white rabbit is fixed on the operating table in a supine position...

2021-03-25
[Animal modeling]-Thioacetamide (TAA) induced liver failure model

[Animal modeling]-Thioacetamide (TAA) induced liver failure model

  Replication method Adult rats, intraperitoneal injection of thioacetamide (TAA) 250-350 mg/kg body weight, subcutaneous injection of 600 mg/kg body weight, or oral gavage method of 300-400 mg/kg body weight, each rat for 24 hours Rear...

2021-03-24
[Animal Modeling]-Acetaminophen-induced liver failure model

[Animal Modeling]-Acetaminophen-induced liver failure model

Replication method Adult mice were injected with paracetamol (APAP) at a dose of 900 mg/kg body weight, adult rats were injected with 500 mg/kg body weight of APAP in the same way, or adult experimental dogs were injected with dimethyl to dissolve AP...

2021-03-24
【Animal modeling】-Carbon tetrachloride induced liver failure model

【Animal modeling】-Carbon tetrachloride induced liver failure model

Breeding method Adult male rats are forcibly taken orally with 10 ml/kg body weight of 40% CCl4 oil solution, or adult dogs are intraperitoneally injected with 0.9 ml/kg body weight of 50% CCl4 oil solution. The color is the skin of the animal. Obser...

2021-03-24
【Animal Modeling】-Atherosclerosis animal model and characteristics

【Animal Modeling】-Atherosclerosis animal model and characteristics

As early as 1908, Ignatowski and others recognized that a high-cholesterol diet may be related to the formation of experimental atherosclerosis. In 1913, Anichkov and Chalatov established the first atherosclerotic rabbit model with a high-cholesterol...

2021-03-24
[Animal Modeling]-Model of liver cirrhosis induced by common bile duct ligation

[Animal Modeling]-Model of liver cirrhosis induced by common bile duct ligation

Regeneration method Adult rats were anesthetized by umbilical cord median sternotomy, and the common hepatic bile duct was sutured 1 cm away from the hilum with 7-0 silk thread...

2021-03-24
【Animal Modeling】-animal model of stress duodenal ulcer

【Animal Modeling】-animal model of stress duodenal ulcer

Feeding method Adult rats were fasted with water for 16 hours, anesthetized by intraperitoneal injection of sodium pentobarbital, fixed, and then pressed into the coat with electric clippers. The area was slightly larger than the burned area. Pat the...

2021-03-23
【Animal Modeling】-an animal model of chronic gastric ulcer induced by duodenal reflux surgery

【Animal Modeling】-an animal model of chronic gastric ulcer induced by duodenal reflux surgery

Breeding methods Adult rats anesthetized with sodium pentobarbital were fasted for 24 hours without taking water, a midline incision was made in the supine position, the abdomen was opened, left and right anastomosis, and fasting for 3 days after the...

2021-03-23
【Animal Modeling】-Animal model of chronic gastric ulcer induced by acetic acid burning method

【Animal Modeling】-Animal model of chronic gastric ulcer induced by acetic acid burning method

  Reproduction method Anesthetize adult rats with sodium pentobarbital, cut the abdomen into a supine position, and inject 0.01 to 0.05 ml of 20% to 100% acetic acid into the anterior wall of the gastric antrum with tuberculin...

2021-03-23
【Animal Modeling】-Animal model of chronic atrophic gastritis induced by gastrointestinal anastomosis

【Animal Modeling】-Animal model of chronic atrophic gastritis induced by gastrointestinal anastomosis

Breeding method Adult rats fasted for 18 hours, injected pentobarbital sodium 30 mg/kg body weight intraperitoneally under anesthesia, opened the stomach, exposing the stomach and jejunum, and placed the forearm about 2 cm...

2021-03-23