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【Animal Modeling】-Using monocrotaline to replicate the rat pulmonary hypertension model

【Animal Modeling】-Using monocrotaline to replicate the rat pulmonary hypertension model

Monocrotaline (MCT) is a plant extract of the genus Crotalaria. It is a double-layer pyrrolidine alkaloid that can carbonize the DNA of cancer cells and exert anti-cancer effects, mainly after injection in the body...

2023-06-01
【Animal modeling】-Losartan reduces ventilator-related lung injury in mice and inhibits the expression of caveolin-1 and NOX4 in lung tissue

【Animal modeling】-Losartan reduces ventilator-related lung injury in mice and inhibits the expression of caveolin-1 and NOX4 in lung tissue

To establish a mouse model of mechanical lung injury by ventilator hyperventilation, intervene with angiotensin II receptor inhibitor losartan, and explore the effect of losartan on caveolin-1 in the lung of mice with mechanically ventilated lung inj...

2023-05-31
【Animal modeling】-Experimental study on growth and reproduction of Tlr4 knockout mice

【Animal modeling】-Experimental study on growth and reproduction of Tlr4 knockout mice

To study the similarities and differences in growth and reproduction between Tlr4 knockout mice and KM mice...

2023-05-31
【Animal Modeling】-The effect of four commonly used experimental anesthetics on the cardiovascular system of rats

【Animal Modeling】-The effect of four commonly used experimental anesthetics on the cardiovascular system of rats

Explore the effects of anesthetics in different animal experiments on the cardiovascular system of rats...

2023-05-31
【Animal Modeling】-The effect of self-made Gehua Jiejiu Dizhi Decoction on liver fat deposition and PXR expression in alcoholic fatty liver mice

【Animal Modeling】-The effect of self-made Gehua Jiejiu Dizhi Decoction on liver fat deposition and PXR expression in alcoholic fatty liver mice

Understand the effect of Gehua Jiejiu Dizhi Decoction on liver fat deposition in alcoholic fatty liver (AFLD) mice, and observe its effect on liver tissue pregnane receptor (PXR) and its regulatory target genes CYP3A11 and CYP3A25 proteins...

2023-05-31
【Animal Modeling】-Fluorescence two-dimensional electrophoresis to detect the differences in liver tissue proteomics between male and female mice

【Animal Modeling】-Fluorescence two-dimensional electrophoresis to detect the differences in liver tissue proteomics between male and female mice

To detect the differences in the expression of proteomes in the liver tissue of male and female mice, and to explore the mechanism of gender differences in the occurrence of liver diseases...

2023-05-31
【Animal Modeling】-Analysis of Bacterial Community Diversity in Large Intestine Contents of Tree Shrews

【Animal Modeling】-Analysis of Bacterial Community Diversity in Large Intestine Contents of Tree Shrews

To analyze the structure and composition of E. coli bacteria in tree shrew by high-throughput sequencing technology...

2023-05-30
【Animal modeling】-Propofol protects against cerebral ischemia-reperfusion injury and may be related to the inhibition of gap junction function

【Animal modeling】-Propofol protects against cerebral ischemia-reperfusion injury and may be related to the inhibition of gap junction function

To investigate the relationship between the protective effect of propofol on cerebral ischemia-reperfusion injury and gap junctions and its possible mechanism...

2023-05-30
【Animal Modeling】-The mechanism of acute hyperglycemia affecting the first phase insulin secretion in mice

【Animal Modeling】-The mechanism of acute hyperglycemia affecting the first phase insulin secretion in mice

To observe the function and morphological changes of acute hyperglycemia affecting the first phase insulin secretion in mice...

2023-05-29
【Animal modeling】-Isolation and identification of mouse CD4+ T cell exosomes

【Animal modeling】-Isolation and identification of mouse CD4+ T cell exosomes

To investigate whether CD4+ T cells have the ability to secrete exosomes, and the possibility of CD4+ T cell exosomes participating in inflammation and tumor immune processes...

2023-05-29
【Animal Modeling】-Bupivacaine-induced Myocardial Cell Mitochondria Damage Rat Model

【Animal Modeling】-Bupivacaine-induced Myocardial Cell Mitochondria Damage Rat Model

Observe the changes in the mitochondrial morphology of bupivacaine cardiomyocytes and the production of reactive oxygen species under electrical stimulation, and explore the establishment of an ideal rat cardiomyocyte model of bupivacaine poisoning...

2023-05-29
【Animal Modeling】-Lanzhou Institute of Chemistry, Chinese Academy of Sciences created a new technology for extracting high-purity deer blood polypeptide

【Animal Modeling】-Lanzhou Institute of Chemistry, Chinese Academy of Sciences created a new technology for extracting high-purity deer blood polypeptide

Recently, the reporter learned from the Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences that the research group of Di Duolong, the Northwest Key Laboratory of Characteristic Plant Resource Chemistry of the Chinese Academy of Scienc...

2023-05-29
【Animal Modeling】-Based on the 3.0 T magnetic resonance imaging system to preliminarily observe the morphological and anatomical structure of the WHBE rabbit brain

【Animal Modeling】-Based on the 3.0 T magnetic resonance imaging system to preliminarily observe the morphological and anatomical structure of the WHBE rabbit brain

Based on 3.0 T magnetic resonance imaging (MRI) technology, the morphological and anatomical structure of the WHBE rabbit brain was observed in vivo, and the basic biological data of the WHBE rabbit brain imaging were accumulated, so as to provide ba...

2023-05-29
Establishment of traction model of ventral nerve root of lumbar spine

Establishment of traction model of ventral nerve root of lumbar spine

In order to study the pathogenesis of amyotrophic lateral sclerosis and drug development, a rat model of the 4th lumbar ventral nerve root traction was established, and brain-derived neurotrophic factor was used as a positive drug to verify the effec...

2023-05-29
【Animal modeling】-Establishment and application of Salmonella LAMP detection method in tree shrew feces

【Animal modeling】-Establishment and application of Salmonella LAMP detection method in tree shrew feces

To establish a loop-mediated isothermal amplification detection method for Salmonella in tree shrew feces, and to make a preliminary application of the method...

2023-05-26
【Animal modeling】-Microsatellite DNA analysis of the genetic status of 24 domestic inbred strains of mice

【Animal modeling】-Microsatellite DNA analysis of the genetic status of 24 domestic inbred strains of mice

To analyze the genetic status of 24 domestic inbred mice using microsatellite loci...

2023-05-26