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【Animal modeling】-M4 receptor blocker MT3 inhibits form deprivation myopia in guinea pigs

【Animal modeling】-M4 receptor blocker MT3 inhibits form deprivation myopia in guinea pigs

To investigate the inhibitory effect of the highly selective M4 receptor blocker MT3 on form deprivation myopia in guinea pigs and its potential mechanism...

2022-03-25
【Animal modeling】-Effect and mechanism of Shenqu Xiaoshi oral liquid on gastrointestinal motility in mice with functional dyspepsia

【Animal modeling】-Effect and mechanism of Shenqu Xiaoshi oral liquid on gastrointestinal motility in mice with functional dyspepsia

To explore the effect and mechanism of Shenqu Xiaoshi Oral Liquid on gastrointestinal motility in functional dyspepsia (FD) mice...

2022-03-25
【Animal Modeling】-Effects of experimental intervention of normal saline on caecal microflora and short-chain fatty acid content in broilers

【Animal Modeling】-Effects of experimental intervention of normal saline on caecal microflora and short-chain fatty acid content in broilers

To study the effects of experimental intervention of normal saline on the microflora and content of short-chain fatty acids in the caecum of broilers, in order to provide a theoretical basis for the study of early microbiota intervention experiments...

2022-03-25
【Animal Modeling】-Effects of ethinylestradiol exposure before pregnancy on changes in glucose metabolism and the expression of genes related to hepatic glucose metabolism in offspring of rats

【Animal Modeling】-Effects of ethinylestradiol exposure before pregnancy on changes in glucose metabolism and the expression of genes related to hepatic glucose metabolism in offspring of rats

To use SD rats as a model to observe the effects of pre-pregnancy ethinyl estradiol exposure on the changes of glucose metabolism in offspring and the expression of genes related to glucose metabolism in the liver...

2022-03-25
【Animal Modeling】-Glucagon-like polypeptide-1 improves learning and memory ability in type 2 diabetic rats

【Animal Modeling】-Glucagon-like polypeptide-1 improves learning and memory ability in type 2 diabetic rats

To observe the improvement effect of diabetes treatment drug glucagon-like peptide-1 (GLP-1) on learning and memory dysfunction in diabetic rats...

2022-03-25
【Animal modeling】-Effect of curcumin on glucose transport and PI3K/Akt signaling pathway in adipocytes of type 2 diabetic rats

【Animal modeling】-Effect of curcumin on glucose transport and PI3K/Akt signaling pathway in adipocytes of type 2 diabetic rats

To investigate the effect of curcumin on glucose transport and phosphatidylinositol kinase-3 (PI3K)/protein kinase B (Akt) signaling pathway in adipocytes of type 2 diabetes mellitus (T2DM) rats...

2022-03-25
【Animal modeling】-Experimental observation of porcine circovirus type 3 infection in BALB/c mice

【Animal modeling】-Experimental observation of porcine circovirus type 3 infection in BALB/c mice

To study the infection of porcine circovirus type 3 in BALB/c mice...

2022-03-25
【Animal modeling】-Study on the protective effect of salvianolic acid A on the kidney of ZDF rats and the inhibition of lipoprotein-associated phospholipase A2

【Animal modeling】-Study on the protective effect of salvianolic acid A on the kidney of ZDF rats and the inhibition of lipoprotein-associated phospholipase A2

To observe the protective effect of salvianolic acid A on nephropathy in Zucker diabetic obese rats and its effect on the expression of lipoprotein-related phospholipase A2...

2022-03-25
【Animal modeling】-Effect of Astragalus on endoplasmic reticulum stress response in vascular remodeling in hypertensive rats

【Animal modeling】-Effect of Astragalus on endoplasmic reticulum stress response in vascular remodeling in hypertensive rats

To study the effect of Astragalus on endoplasmic reticulum stress response (ERS) in vascular remodeling in hypertensive rats, and to explore the molecular mechanism of its vascular protection...

2022-03-25
【Animal modeling】-The effect of vasoactive intestinal peptide on the prevention and treatment of experimental autoimmune encephalomyelitis by regulating the balance of CD4+CD25+Treg/Th17

【Animal modeling】-The effect of vasoactive intestinal peptide on the prevention and treatment of experimental autoimmune encephalomyelitis by regulating the balance of CD4+CD25+Treg/Th17

To investigate the effect of vasoactive intestinal peptide regulating the balance of CD4+CD25+Treg/Th17 on the prevention and treatment of experimental autoimmune encephalomyelitis...

2022-03-25
【Animal Modeling】-Preliminary study on the effect of lipopolysaccharide on the lung tissue of naked mole rats

【Animal Modeling】-Preliminary study on the effect of lipopolysaccharide on the lung tissue of naked mole rats

To observe and analyze the effect of lipopolysaccharide on the morphological structure and pathological indexes of naked mole rat lung, and to preliminarily explore whether naked mole rat has LPS tolerance...

2022-03-25
【Animal Modeling】-Different effects of dietary fat on physiological and biochemical indicators in mice under different diet models

【Animal Modeling】-Different effects of dietary fat on physiological and biochemical indicators in mice under different diet models

To explore the differences in physiological and biochemical indicators of different lipids in mice under different feed models, and to provide experimental basis for the selection and evaluation of animal model feed lipids and the use of oils for hum...

2022-03-24
【Animal Modeling】-Lactobacillus rhamnosus culture supernatant prevents Escherichia coli meningitis by inhibiting NF-κB pathway

【Animal Modeling】-Lactobacillus rhamnosus culture supernatant prevents Escherichia coli meningitis by inhibiting NF-κB pathway

To investigate whether Lactobacillus rhamnosus supernatant (LGG-CM) can block bacterial meningitis caused by E. coli K1 strain by inhibiting NF-κB pathway in vitro...

2022-03-24
【Animal Modeling】-The neuroprotective effect and autophagy of artesunate in mice with experimental autoimmune encephalomyelitis

【Animal Modeling】-The neuroprotective effect and autophagy of artesunate in mice with experimental autoimmune encephalomyelitis

To investigate the neuroprotective effect and autophagy of artesunate in mice with experimental autoimmune encephalomyelitis...

2022-03-24
【Animal Modeling】-Effect and mechanism of fine particulate matter PM2.5 on atherosclerosis in ApoE knockout mice

【Animal Modeling】-Effect and mechanism of fine particulate matter PM2.5 on atherosclerosis in ApoE knockout mice

The purpose of this experiment was to investigate the effect and mechanism of fine particulate matter PM2.5 on ApoE knockout (Apoe-/-) mice (atherosclerosis model mice)....

2022-03-24
【Animal Modeling】-Determination and Comparison of Hematological Indexes of Cynomolgus Monkeys in Juvenile Experiments

【Animal Modeling】-Determination and Comparison of Hematological Indexes of Cynomolgus Monkeys in Juvenile Experiments

To determine the hematological indexes of 853 normal juvenile cynomolgus monkeys, and to establish the reference range of normal values of hematological indexes for each age group of juvenile experimental cynomolgus monkeys in Guangdong Province...

2022-03-24