【Animal Modeling】-Identified the neural circuits activated in the anterior cingulate gyrus cortex of mice during transference

In a new study, Monique Smith, Naoyuki Asada, and Robert Malenka from Stanford University found that when the pain, fear, and pain of other mice were relieved, certain parts of the mouse brain became active Neural circuit...

2021-11-06

Zebrafish eye tumor model

Retinoblastoma (Retinoblastoma, RB) is a common eye cancer in children. Among infant eye diseases, it is the most serious and harmful malignant tumor...

2021-11-06

[Animal modeling]-Comparison of bioluminescence imaging and SPECT/CT in animal models of lung adenocarcinoma brain metastasis

Establish a biological model of luc + -PC-9 human lung adenocarcinoma cells stably expressing luciferase, bioluminescence imaging and 18F-FDG (18F-fluorodeoxyglucose, 18F-fluoro) deoxyglucose to establish animals with lung cancer brain metastasis mod...

2021-11-06

[Animal Modeling]-Realize damaged optic nerve regeneration in animal experiments

Damage to fully developed nerve cells has irreversible consequences, because nerve fibers lose their ability to regenerate when they mature...

2021-11-05

[Animal experiment]-Alzheimer\'s disease drug induces brain cell damage in mice

Animal experiments similar to the treatment of human Alzheimer’s show that the treated antibodies may actually be harmful...

2021-11-05

【Animal Modeling】-Effects of repeated propofol anesthesia on spatial memory and long-term enhancement of young rats under hypoxic conditions

Propofol is the most commonly used intravenous induction and maintenance anesthesia. Hypoxemia is a common complication during anesthesia...

2021-11-05

What is the pathogenesis of pseudorabies? -【Animal Modeling】

Pseudorabies (also known as \\\"pseudorabies\\\") is an acutely fatal disease caused by the pseudorabies virus, which belongs to the subfamily herpes disease of the virus genus and the subfamily alpha herpesvirus...

2021-11-05

A major breakthrough in AIDS treatment! Remove HIV-1 virus from human immune cells

Human acquired immunodeficiency virus (HIV) is a nightmare in the medical profession. Since the disease has expanded for decades, no way can be found to completely cure the patient. The only option is to take cocktail therapy or take antiretroviral d...

2021-11-05

【Animal Modeling】-Cyclophosphamide-induced rabbit premature ovarian failure animal model

Compare different injection methods to establish animal models of cyclophosphamide-induced primary ovarian insufficiency, find the best modeling method, and provide a more suitable experimental model for further research on early ovarian insufficienc...

2021-11-05

【Animal Modeling】-Subcutaneous injection of Mercury Nephropathy model

Replication method (1) Adult dogs, subcutaneously inject 2% mercury solution from the abdomen, the injection volume is 20 mg/kg body weight...

2021-11-05

[Animal Modeling]-Preventive administration of all-trans retinoic acid can reduce inflammation in rats with rheumatoid arthritis

To study the effect of all-trans retinoic acid (ATRA) on the structure of joint tissue, the expression level and expression of serum-related inflammatory cytokines in the arthritis model of rheumatoid arthritis (CIA) rats induced by type II collagen...

2021-11-05

[Animal Modeling]-Timing is crucial when treating mouse brain swelling

Researchers from the National Institutes of Health found that Jekyll and Hyde immune cells in the brain can eventually help repair the brain, but can cause fatal swelling early after the injury...

2021-11-05

A novel mouse model of Alzheimer\'s disease

Recently, researchers from the University of Oslo published a new research progress in the international academic journal brain. They knocked out two genes in the mouse brain and constructed a new mouse model of Alzheimer’s disease. Different mouse m...

2021-11-05

【Animal Modeling】-Monocular limited photocell degeneration model in rabbits

Retinitis pigmentosa is a degenerative disease of the retina that causes night blindness and eventual loss of peripheral and central visual fields...

2021-11-05

Measurement of right ventricular pressure in a mouse model of pulmonary hypertension by intercostal muscle puncture

Establish a fast and efficient method for measuring right ventricular pressure in mice without the aid of a ventilator and easy to operate, and discuss the measurement techniques...

2021-11-05

Massachusetts Institute of Technology uses CRISPR to build mouse cancer models

Genome sequencing of tumor cells has revealed thousands of cancer-related mutations. Breeding mouse strains with genetic defects is one way to reveal the effects of these mutations, but breeding such mice is a costly and time-consuming process...

2021-11-05