[Animal modeling]-Estrogen reduces the microvascular injury induced by chronic hypoperfusion in the rat brain by up-regulating the expression of VEGF

17-β-estradiol (E2) replacement therapy to study the pathological changes of the brain microvascular system after permanent ligation of bilateral common carotid arteries (BCCAO) in rats and the effect of E2 replacement at different times. The treatme...

2021-07-14

【Animal Modeling】-The effect of IL-27 and its receptor on the proliferation and transformation of lung fibroblasts

To explore the effects of IL-27 and its receptor (WSX-1) on the proliferation, transformation and collagen synthesis of mouse lung fibroblasts induced by TGF-β1...

2021-07-14

Effects of Bile Duct Ligation and Recanalization on Cell Phenotype and NOX4 Protein Expression in Rat Liver

Design and establish a rat liver fibrosis model with biliary tract ligation and recanalization to observe the effect of biliary tract ligation and recanalization on the epithelial mesenchymal phenotype and the expression of oxidative stress-related p...

2021-07-14

【Animal Modeling】-Nrf2 Antioxidant Pathway Protects Rat Acute Liver Injury Induced by CCl4

To study the protective effect of Nrf2 oxidative damage pathway on CCl4-induced acute liver injury in rats...

2021-07-13

[Animal modeling] The protective effect of -γ-secretase inhibitor on the white matter damage of neonatal rats induced by hyperoxia exposure

To explore the effect of γ-secretase inhibitor (N-[N-(3, 5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester, DAPT) on the brain white matter damage of neonatal mice exposed to normal pressure and high concentration oxygen Role in...

2021-07-13

【Animal Modeling】-The protective effect of piperphentonamine hydrochloride on gentamicin-induced hearing damage in guinea pigs

Cochlear autophagy-related proteins beclin1 and LC3, Na + -K + -2Cl- complex transporter (NKCC1) mRNA, endoserine (ET) expression, cochlear gentamicin (GM) damage and pipefenone amine hydrochloride (PPTA) Observe relationship protection and damage me...

2021-07-13

Immune protection of Sap2 protein and dendritic cells against systemic Candida albicans infection

Immunize mice with recombinant protein and dendritic cells (DC) to observe its protective effect on systemic Candida albicans...

2021-07-13

Effect of chronic intermittent hypoxia on the expression of glucose transporter 4 in skeletal muscle of rats

To investigate the effects of inflammatory factors caused by chronic intermittent hypoxia-reoxygenation on glucose metabolism and skeletal muscle glucose transporter 4 (GLUT-4) expression in rats...

2021-07-13

【Animal Modeling】-The changes in the EEG activity of the submarginal zone in morphine-dependent rats during the period of drug-seeking subsidence

To explore the effect and mechanism of the changes in EEG activity in the subliminal cortex on the drug-seeking behavior during the sinking process of morphine-dependent rats...

2021-07-13

Experimental study on the changes of platelet mitochondria after tourniquet limb ischemia-reperfusion injury in rats

Targeting rapamycin to inhibit mTOR and study its effect on the proliferation of rat heart valve interstitial cells...

2021-07-13

【Animal Modeling】-The effect of rapamycin on the proliferation of rat aortic valve interstitial cells

Targeting rapamycin to inhibit mTOR and study its effect on the proliferation of rat heart valve interstitial cells...

2021-07-13

【Animal Modeling】-Study on the subacute inhalation toxicity of Ivermectin to rats

Study the subacute inhalation toxicity of ivermectin to rats and find the maximum unaffected dose...

2021-07-13

【Animal Modeling】-Effect of alcohol exposure during pregnancy on basic rhythmic respiratory discharge in medulla oblongata of newborn rats

To explore the effect of alcohol exposure during pregnancy on the basic rhythmic respiratory discharge activity (RRDA) of the medulla oblongata slices of newborn rats...

2021-07-12

To observe the inducing effect of temozolomide on the programmed death of rat glioma C6 cells and its possible molecular mechanism

To observe the inducing effect of temozolomide on the programmed death of rat glioma C6 cells and its possible molecular mechanism...

2021-07-12

【Animal Modeling】-High-intensity focused ultrasound inhibits the metastasis of mouse melanoma cells B16-F10 in vivo

To study the effect of high-intensity focused ultrasound (HIFU) treatment on the metastasis of melanoma cells in a mouse model of melanoma...

2021-07-12

【Animal Modeling】-The role of KA1 subreceptor in the death of hippocampal neurons caused by endoplasmic reticulum stress

To explore the role of up-regulation of KA1 subreceptor expression in the death of hippocampal neurons caused by endoplasmic reticulum stress...

2021-07-12