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[Animal Modeling - Pharmacodynamic Evaluation] - Small Pig Root Absorption Model

[Animal Modeling - Pharmacodynamic Evaluation] - Small Pig Root Absorption Model

Root resorption is a common and difficult to treat complication in orthodontic treatment, and there are many related factors that can cause root resorption, including age, gender, nutritional status, type of orthodontic device, orthodontic force, ort...

2024-07-08
[Animal Modeling - Pharmacodynamic Evaluation] - Repair of Bone Defects Around Small Pig Implants

[Animal Modeling - Pharmacodynamic Evaluation] - Repair of Bone Defects Around Small Pig Implants

Implant restoration has been increasingly widely used in clinical practice, but the loss of teeth due to trauma, tumors, periodontal disease and other reasons often leads to excessive absorption of alveolar bone, resulting in insufficient bone mass a...

2024-07-08
[Animal modeling - Pharmacodynamic evaluation] - Small pig pulpitis model

[Animal modeling - Pharmacodynamic evaluation] - Small pig pulpitis model

Five Chinese experimental miniature pigs weighing 14-26kg were used, with three males and two females. Select the first permanent molars of the upper and lower jaw, and create a pulpitis model with bilateral mandibular lateral incisors. After injecti...

2024-07-08
【Animal modeling - Pharmacodynamic evaluation】 - Immune normal mouse leprosy foot pad infection model

【Animal modeling - Pharmacodynamic evaluation】 - Immune normal mouse leprosy foot pad infection model

CFW, CBA, BALB/c, DBA, and Kunming mice are all sensitive animals. Inoculate 50ml/3ml of bacteria per foot pad, and after 6-8 months, it can proliferate to 1000000. Generally, 5-8 months after inoculation is a logarithmic growth period, and then ente...

2024-07-08
[Animal Modeling Pharmacodynamic] Evaluation Kidney Deficiency Syndrome Animal Model

[Animal Modeling Pharmacodynamic] Evaluation Kidney Deficiency Syndrome Animal Model

The kidney is the foundation of congenital diseases. Kidney deficiency syndrome is one of the main types of syndromes in traditional Chinese medicine, mainly including kidney yang deficiency, kidney yin deficiency, kidney qi deficiency, and kidney es...

2024-07-08
[Animal modeling - efficacy evaluation] - induced diabetes retinopathy animal model

[Animal modeling - efficacy evaluation] - induced diabetes retinopathy animal model

In diabetes, the retina is exposed to high concentration of plasma glucose, and intracellular free glucose accumulates, activating aldose reductase, the key enzyme of sorbitol metabolism. The production of sorbitol is accelerated, and sorbitol accumu...

2024-07-08
[Animal Modeling - Pharmacodynamic Evaluation] - Caries Animal Model

[Animal Modeling - Pharmacodynamic Evaluation] - Caries Animal Model

Caries is a progressive damage to dental hard tissue caused by a combination of factors such as bacteria, food, host, and time. If left untreated, the disease can continue to develop, leading to the formation of caries cavities and secondary pulpitis...

2024-07-08
[Animal Modeling Pharmacodynamic] Evaluation Choroidal Melanoma Animal Model

[Animal Modeling Pharmacodynamic] Evaluation Choroidal Melanoma Animal Model

The incidence rate of choroidal melanoma in China is second only to retinoblastoma in children, and it is the most common intraocular malignant tumor in adults...

2024-07-08
[Animal Modeling - Pharmacodynamic Evaluation] - Inducing Lymphoma Animal Model

[Animal Modeling - Pharmacodynamic Evaluation] - Inducing Lymphoma Animal Model

Chemically induced lymphoma animal model...

2024-07-08
[Animal Modeling Pharmacodynamic Evaluation ]- Spontaneous Leukemia Animal Model

[Animal Modeling Pharmacodynamic Evaluation ]- Spontaneous Leukemia Animal Model

AKR spontaneous leukemia mice are born with oncogenic RNA viruses, and their therapeutic response to drugs is similar to that of childhood acute lymphoblastic leukemia...

2024-07-08
[Animal modeling - efficacy evaluation] - induced bladder cancer animal model

[Animal modeling - efficacy evaluation] - induced bladder cancer animal model

There are two types of ideal chemical carcinogens to induce animal bladder cancer: nitroso compounds represented by N-butyl-N - (4-hydroxybutyl-1) - nitrosamine (BBN) and N * methyl-N-nitrosourea (MNU) and nitro compounds represented by N - [4- (5-ni...

2024-07-08
[Animal modeling - efficacy evaluation] - animal model of induced breast cancer

[Animal modeling - efficacy evaluation] - animal model of induced breast cancer

Inducing tumor model is the use of chemical, biological carcinogens or radiation to induce mouse tumors under certain conditions, mainly through chemical induction of tumors. The commonly used inducers are methylnitrosourea or DMBA, which are used to...

2024-07-08
[Animal modeling - efficacy evaluation] - Gene modified bladder cancer animal model

[Animal modeling - efficacy evaluation] - Gene modified bladder cancer animal model

Gene modified bladder cancer animal models can be divided into microinjection method, retroviral infection method and embryonic stem cell method according to the way of gene introduction, of which microinjection method is more mature. Microinjection...

2024-07-08
[Animal modeling - Pharmacodynamic evaluation] - Mercury induced acute renal failure model in rabbits

[Animal modeling - Pharmacodynamic evaluation] - Mercury induced acute renal failure model in rabbits

  After being filtered by the glomerulus, ions are reabsorbed by renal tubular epithelial cells and accumulate within the cells. They bind with the cell membrane and intracellular thiol and disulfide groups, affecting cellular enzyme activity, damagi...

2024-07-08
【Animal modeling - Pharmacodynamic evaluation 】- Animal model of renal tubulointerstitial fibrosis

【Animal modeling - Pharmacodynamic evaluation 】- Animal model of renal tubulointerstitial fibrosis

Ligation of renal veins leads to renal ischemia and tubular injury, resulting in ischemic atrophy and tubular disappearance, renal interstitial hyperplasia, and renal tubulointerstitial fibrosis...

2024-07-08
【Animal modeling】-Protective effect of acupuncture combined with Danhong injection on cerebral ischemia-reperfusion injury in rats

【Animal modeling】-Protective effect of acupuncture combined with Danhong injection on cerebral ischemia-reperfusion injury in rats

To study whether acupuncture combined with Danhong injection has protective effect on cerebral ischemia-reperfusion injury in rats...

2024-07-05