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Marmoset animal model susceptible to Middle East respiratory coronavirus

Marmoset animal model susceptible to Middle East respiratory coronavirus

Recently, in a research paper published in the international journal PLoS Pathogens, staff from the National Institute of Allergy and Infectious Diseases developed for the first time an animal model that can simulate the symptoms of Middle East Respi...

2020-11-30
Rodent models in drug development

Rodent models in drug development

In terms of cognitive ability research, researchers have made great progress using animal experiments. The next step is to build a rodent model that can be used for drug development...

2020-11-30
Autophagy activation can increase hippocampal neuron damage in rats with vascular dementia

Autophagy activation can increase hippocampal neuron damage in rats with vascular dementia

Immunohistochemical staining showed that the expression of autophagy-related protein Beclin-1 in hippocampal CA1 area decreased after wortmannin, an autophagy inhibitor, interfered with vascular dementia model rats...

2020-11-30
New breakthrough in personalized cancer treatment: constructing cancer mice that are the same as patients

New breakthrough in personalized cancer treatment: constructing cancer mice that are the same as patients

In a laboratory in Baltimore, USA, there is a scene where a hairless mouse is placed in rows of plastic boxes, and a yellow card is attached to each box. In fact, each mouse corresponds to a patient who is fighting cancer. These mice are the embodime...

2020-11-30
Successful screening of drug candidates for deadly brain diseases using worm models

Successful screening of drug candidates for deadly brain diseases using worm models

Recently, researchers at the University of Liverpool have successfully constructed a worm model of an incurable and fatal neurodegenerative disease, and used this worm model to screen a potential compound that can treat the disease...

2020-11-30
Use mouse models to further clarify the relationship between inflammation and cancer

Use mouse models to further clarify the relationship between inflammation and cancer

A research team led by Dr. Nadia Carlesso, associate professor of pediatrics at Indiana University, found that, like a series of fallen dominoes, a series of molecular events in the bone marrow can produce high levels of inflammation, which can disru...

2020-11-30
New functions of cells related to lung ventilation discovered in mouse model studies

New functions of cells related to lung ventilation discovered in mouse model studies

Researchers at Stanford University School of Medicine in the United States found that squamous type 1 alveolar cells (AT1 cells) and cuboid type 2 alveolar cells (AT2 cells) developed from a kind of \\\"dual potential\\\" progenitor cells. ...

2020-11-30
The Institute of Zoology, Chinese Academy of Sciences uses CRISPR technology to establish a small pig model of von Willebrand disease

The Institute of Zoology, Chinese Academy of Sciences uses CRISPR technology to establish a small pig model of von Willebrand disease

A research team led by Zhou Qi, a researcher at the Institute of Zoology, Chinese Academy of Sciences, used CRISPR/Cas9 technology to obtain vWF knockout pigs for the first time, thereby establishing a miniature pig model of von Willebrand disease...

2020-11-30
New animal model reveals the role of isocitrate dehydrogenase mutations in leukemia

New animal model reveals the role of isocitrate dehydrogenase mutations in leukemia

In recent years, mutations in two metabolic enzymes, isocitrate dehydrogenase 1 and isocitrate dehydrogenase 2 (IDH1 and IDH2), have been determined to be present in approximately 20% of acute myeloid leukemia (AML)...

2020-11-30
Realize damaged optic nerve regeneration in animal experiments

Realize damaged optic nerve regeneration in animal experiments

Damage to fully developed nerve cells can have irreversible consequences, because once nerve fibers mature, they lose their ability to regenerate. New experiments show that activating a part of the nerve cell regeneration mechanism, a protein called ...

2020-11-27
Study on the symptoms of spontaneous hindlimb paralysis in hyperlipidemia susceptible (WSHc) rats

Study on the symptoms of spontaneous hindlimb paralysis in hyperlipidemia susceptible (WSHc) rats

Observe the pathogenesis and pathological characteristics of spontaneous hind limb paralysis rats in the hyperlipidemia susceptible (WSHc) rat population, and preliminary study its pathogenesis, and explore its application and scientific research val...

2020-11-27
Effects of Astragalus Polysaccharides on Growth Performance, Blood Physiological and Biochemical Indexes and Incidence of Diarrhea in Reproductive Macaques

Effects of Astragalus Polysaccharides on Growth Performance, Blood Physiological and Biochemical Indexes and Incidence of Diarrhea in Reproductive Macaques

By feeding astragalus polysaccharides on the growth performance, blood physiology and biochemistry and the incidence of diarrhea in reproductive macaques, research the application of astragalus polysaccharides in the feeding and management of laborat...

2020-11-27
Application of lactose-free milk powder with deep hydrolyzed protein in the cultivation of sterile rats

Application of lactose-free milk powder with deep hydrolyzed protein in the cultivation of sterile rats

In the cultivation of sterile rats, artificially formulated milk fed after birth is essential for the cultivation of sterile rats...

2020-11-27
Scientists identify compounds that stimulate muscle cells in mice

Scientists identify compounds that stimulate muscle cells in mice

Researchers at the University of California, Los Angeles have identified a compound that can replicate the effects of exercise in the muscle cells of mice...

2020-11-27
Isoliquiritin improves inflammatory response in mice with acute kidney injury induced by cisplatin through Smad3/Arid2-IR/NF-κB axis

Isoliquiritin improves inflammatory response in mice with acute kidney injury induced by cisplatin through Smad3/Arid2-IR/NF-κB axis

To study the effect of isoliquiritin (ISO) on cisplatin-induced acute kidney injury (AKI) mice and explore the underlying regulatory mechanism...

2020-11-27
Línchuáng qián dòngwù shíyàn biǎomíng yuán zì Vd2-T xìbāo de wài mì tǐ kě gāoxiào kòngzhì EBV xiāngguān zhǒngliú, yòudǎo T xìbāo kàng zhǒngliú miǎnyì fǎnyìng 47/5000 Preclinical animal experiments sho

Línchuáng qián dòngwù shíyàn biǎomíng yuán zì Vd2-T xìbāo de wài mì tǐ kě gāoxiào kòngzhì EBV xiāngguān zhǒngliú, yòudǎo T xìbāo kàng zhǒngliú miǎnyì fǎnyìng 47/5000 Preclinical animal experiments sho

In a new study, researchers from the University of Hong Kong and the University of Science and Technology of China reported that exosomes derived from Vδ2-T cells (hereinafter referred to as Vδ2-T-Exos) can effectively control Epstein-Barr virus ( EB...

2020-11-27