[Animal modeling]- Animal model of guinea pig gallstones induced by lithogenic feed

Female guinea pigs, weighing 250-300g; Medication: Stone feed (formula: add 1.5% sucrose, 1% casein, 1% lard, 1% cellulose, 0.02% bile acid, and 0.05% cholesterol to the basic food)...

2024-03-12

[Animal modeling] - High sugar diet induced gallstone animal model

Syrian hamsters, weighing around 50-60g; Medication: High sugar bait (formula: sucrose 74%, casein 21%, salt 4.4%, choline 0.1%, concentrated fish liver oil 0.5%)...

2024-03-12

【Animal modeling】 - bile duct cyst animal model

sheep or goats (within 14 days after birth), regardless of gender; Medication: pentobarbita...

2024-03-12

【Animal Modeling】-Comparison of Two Staining Methods for Rat Vaginal Smears

To find a simple staining method for determining the four stages of the rat estrous cycle by staining the vaginal smears of SD female rats to observe the cell morphology...

2024-03-12

【Animal Modeling】-Effect of Guiji Cream on fibronectin and basic fibroblast growth factor in a rat model of stage III pressure ulcer

The purpose of this study was to investigate the effect of Guiji cream on the levels of fibronectin and basic fibroblast growth factor in pressure ulcer granulation tissue in pressure ulcer model rats...

2024-03-12

[Animal modeling] - Zhenqi Fuzheng Granule inhibits angiogenesis in liver cancer model rats through miR-200c/ZEB pathway

To explore the inhibitory effect of Zhenqi Fuzheng Granule on angiogenesis in rat model of liver cancer and its possible mechanism...

2024-03-12

【Animal Modeling】-miR-144 negatively regulates the expression of TOLL-like receptor 2 in rat macrophages

To clarify the relationship between the effects of TOLL-like receptor 2 (TLR2) and microRNA144 (miR-144)...

2024-03-12

【Animal Modeling】-Mice model of lung metastasis and postoperative recurrence after bone marrow injection

Establish a model of bone marrow injection for the treatment of lung metastasis and postoperative recurrence, clarify the superiority and feasibility of the model established by bone marrow injection, and provide a new research basis for the study of...

2024-03-11

[Animal modeling] - Obesity model of small pigs induced by high sugar and high-fat diet

To investigate the effect of high fat and high sugar diet on fat distribution and blood biochemical indexes in Bama miniature pigs...

2024-03-11

[Animal modeling] - Establishment and applicability evaluation of animal model of pelvic organ prolapse

To establish a rat model that can reflect the similar pathological changes of sacral ligaments in patients with pelvic organ prolapse, and to explore the effects of increasing the intensity of birth injury and simulating menopause on the pathology of...

2024-03-11

[Animal modeling] - carbon tetrachloride induces inbred line C57BL/6 mice to establish liver fibrosis model

To compare the effects of different doses of carbon tetrachloride on the induction of liver fibrosis in inbred C57BL/6 mice, so as to establish a stable liver fibrosis model...

2024-03-11

【Animal Modeling】-Establishment of human hepatoma cell orthotopic xenograft model in mice and a comparative study of its characteristics

To select 3 strains of human hepatoma cells and inoculate them in the liver tissue of 4 different immunodeficient mice to establish and compare the orthotopic transplantation tumor models of human hepatoma cells...

2024-03-11

【Animal Modeling】-Construction of BMP-9 Gene Knockout Mice

To use CRISPR/Cas9 technology to knock out the Bmp9 gene fragment in the mouse genome to construct Bmp9 knockout mice...

2024-03-11

【Animal modeling】-Dynamic comparative study of blood and urine biochemistry between two modeling methods for kidney stones

To construct two models of renal calculi in rats, and to provide support for the exploration of the etiology of nephrolithiasis...

2024-03-11

【Animal modeling】-Effect of simvastatin PLGA sustained-release microspheres on intervertebral disc degeneration in rats

To investigate the efficacy of local injection of simvastatin PLGA sustained-release microspheres in the treatment of intervertebral disc degeneration in rats...

2024-03-11

【Animal modeling】-Effect of Roux-en-Y gastric bypass on liver and peripheral insulin sensitivity in type 2 diabetic rats

To observe the changes of insulin sensitivity in the liver and peripheral tissues of type 2 diabetic rats at different times after RYGB and to preliminarily explore the possible mechanism...

2024-03-07