【Animal Modeling】 - Construction and Progress of Dilated Cardiomyopathy Models Focusing on Gene Therapy

Dilated cardiomyopathy is one of the main diseases causing heart failure, with etiological heterogeneity...

2024-02-27

[Animal Modeling] - Research Overview of Vascular Dementia Animal Models

Vascular dementia is based on cerebrovascular disease, which means there are hemorrhagic or ischemic lesions in the brain parenchyma, with ischemia being more common...

2024-02-27

【Animal modeling】-Cloning and molecular characterization of the full-length coding sequence of tree shrew BACE1

To obtain the full-length coding sequence of the tree shrew β-amyloid precursor protein cleaving enzyme BACE1 and analyze its molecular characteristics, so as to provide a basis for the research on the mechanism of AD disease...

2024-02-26

[Animal Modeling] - Research has found that adjusting goat diets can regulate the spread of antibiotic resistance genes

On the 20th, the reporter learned from the Chinese Academy of Agricultural Sciences that the Innovation Team of Ruminant Nutrition and Feed at the Institute of Feed Research of the institute has revealed the changes in gastric microbiota and antibiot...

2024-02-26

[Animal modeling ]- B6-hIGHMBP2 mouse model provides a new approach for the study of neuronal diseases

On January 23, 2024, Vanda Biopharmaceuticals (VNDA) announced that its antisense nucleotide (ASO) drug VCA-894A targeting the IGHMBP2 gene has officially received FDA approval for a new drug clinical trial (IND)...

2024-02-26

[Animal Modeling] - Construction and Evaluation of a Chemotherapy induced Venous Phlebitis Rat Model Induced by Vinorelbine

To construct an animal model and evaluation system of chemotherapy-induced phlebitis induced by injection of Changchun Ruibin injection into the dorsal foot vein of rats...

2024-02-26

[Animal Modeling] - Establishment and Evaluation of a Constipated Irritable Bowel Syndrome Model with Liver Depression Syndrome

Single factor modeling method and multi factor combined modeling method were used to prepare rat models of liver depression syndrome constipation type irritable bowel syndrome (IBS-C). By comparing different indicators, an ideal IBS-C experimental an...

2024-02-26

【 Animal Modeling 】 - Evaluation of Syndrome in a Tidal Heat Model Rat Induced by Bilateral Ovariectomy and Tamoxifen Administration

To explore a syndrome animal model for studying women\'s hot flashes...

2024-02-26

[Animal Modeling] - New Progress in Aging Models of Rodents

Aging is a degenerative process that occurs over time, and age-related diseases are closely related to aging...

2024-02-26

[Animal Modeling] - Application of Gene Modified Animal Models to Study the Progress of Depression

Depression is a complex mental disease with polygene inheritance. Its incidence rate is high, and the serious cases are accompanied by suicide...

2024-02-26

【Animal Modeling】-Characteristics of cardiac structure and function pathological process in a mouse model of pressure overload heart failure

To establish a mouse model of heart failure, and to comprehensively evaluate the characteristic changes of cardiac function and structure during the development of the disease by using ultrasound imaging and pathological techniques...

2024-02-23

【Animal Modeling】-Preliminary Study on the Changes of Tongue Gene Expression Profile in Rats with Qi Stagnation and Blood Stasis Syndrome

To study the changes of the whole gene expression profile in the tongue of rats with qi stagnation and blood stasis syndrome and the biological processes and pathways involved in differential genes by using gene chip technology, in order to provide s...

2024-02-23

【Animal modeling】-Establishment of a mouse model of salt-sensitive hypertension

To establish a mouse model of salt-sensitive hypertension, and use the antihypertensive drug nifedipine to verify the validity of the model....

2024-02-23

【Animal Modeling】-How to establish an animal model of pelvic organ prolapse?

Establish a rat animal model that can reflect similar pathological changes of similar ligaments in patients with pelvic organ prolapse, and explore the effects of increased birth injury intensity and menopausal simulation on the pathology of rat bone...

2024-02-23

[Animal modeling] - Based on autophagy, explore the effect of fentanyl combined with propofol on myocardial ischemia-reperfusion injury in rats

To investigate the effect of fentanyl combined with propofol on myocardial ischemia-reperfusion injury in rats based on autophagy...

2024-02-23

[Animal modeling] - Construction and evaluation of humanized mouse model of pancreatic cancer immune system

To construct and evaluate a humanized mouse model of pancreatic cancer immune system in order to provide an ideal preclinical model for immunotherapy of pancreatic cancer...

2024-02-23