【Animal modeling】-Susceptibility screening of different strains of minipigs to highly pathogenic porcine reproductive and respiratory syndrome virus

To screen minipig strains susceptible to highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) for the evaluation of HP-PRRS live vaccine...

2022-10-22

【Animal Modeling】-Effects of Vanadium Exposure on Inflammatory Response and Migration of Rat Microglia

To observe the effect of sodium metavanadate (NaVO3·2H2O) exposure on the inflammatory response and migration of microglia, and to explore the related mechanism of vanadium neurotoxicity...

2022-10-22

【Animal modeling】-Effect of -FOXO3A on radiation injury of hematopoietic system in mice with total body irradiation

To investigate the effect of FOXO3A on ionizing radiation injury in the hematopoietic system using FOXO3A knockout mice...

2022-10-21

【Animal Modeling】-Inhibitory effect of Camellia oleifera on elevated blood lipids in high-fat diet rats

To investigate the inhibitory effect of a common commercially available Camellia oleifera powder on high-fat diet (HFD)-induced hyperlipidemia...

2022-10-21

[Animal modeling] - Comparative study on pathological damage and intestinal flora of two UC mouse models

To establish a mouse model of ulcerative colitis with dextran sulfate sodium (DSS) and 2,4,6-trinitrobenzene sulfonic acid (TNBS), and compare the clinical symptoms, pathological damage of colon tissue and composition of colonic flora...

2022-10-20

[Animal modeling] - Preliminary study on myocardial injury model of rhesus monkey induced by isoproterenol

To establish a model of myocardial injury induced by isoproterenol in rhesus monkeys...

2022-10-20

[Animal modeling] - Primary cell brain metastasis model of small cell lung cancer

This study intends to isolate and culture primary small cell lung cancer cells that retain the important features and functions of the original tumor, and build a mouse model of SCLC primary cell brain metastasis on this basis, so as to provide a mor...

2022-10-20

[Animal modeling] Study on biological characteristics of tree shrew model of H1N1 influenza virus

To establish a tree shrew model infected with H1N1 influenza virus, and to investigate the dynamics of influenza virus and its distribution in respiratory tissues...

2022-10-20

[Animal modeling] - Preparation and identification of human angiotensin converting enzyme 2 (ACE2) BAC transgenic mouse model

To obtain a humanized mouse model of hACE2 containing the full length hACE2 gene sequence, and to provide an important tool for the research of cardiovascular disease, pathogenesis of COVID-19, and drug and vaccine development...

2022-10-20

[Animal modeling] Establishment of a mouse model of chronic infection with LCMV-CL13 and analysis of its BCR mutation

To establish a mouse model of chronic lymphocytic choriomeningitis virus LCMV-CL13 infection and analyze its possibility as a model for the study of high-frequency mutation of B cell receptor...

2022-10-20

【Animal Modeling】-Parasitic Infection and Drug Purification Effect of Closed Group Meridian Gerbils

To lay a foundation for the establishment of a clean-grade Meridian gerbil population, and to provide a reference for formulating the detection standard of Meridian gerbil parasites...

2022-10-20

【Animal Modeling】-Animal Model of Chronic Bronchitis

Chronic bronchitis (chronic bronchitis) refers to chronic non-specific inflammation of the trachea, bronchial mucosa and surrounding tissues caused by infectious or non-infectious factors. The pathological features of chronic bronchitis are bronchial...

2022-10-20

[Animal modeling] - Overexpression of LAMP2A in substantia nigra improves motor function of Parkinson\'s disease rhesus monkey model

To observe the effect of over expression of lysosome associated membrane protein 2A in substantia nigra on motor behavior of experimental monkeys induced by chaperone mediated autophagy in a Parkinson\'s disease rhesus monkey model...

2022-10-19

[Animal modeling] - Establishment of diffuse cerebral thrombosis model in rats induced by arachidonic acid

To establish and optimize the model of diffuse cerebral thrombosis induced by arachidonic acid in rats...

2022-10-19

[Animal modeling] Preparation of a mouse model of diarrhea predominant irritable bowel syndrome induced by acetic acid combined with restraint stress

To establish a mouse model of diarrhea predominant irritable bowel syndrome (IBS) by rectal perfusion with 3% acetic acid combined with restraint stress, and evaluate the feasibility of the model...

2022-10-19

[Animal modeling] Comparative study on visceral hypersensitivity model induced by combined method

To observe the effect of visceral hypersensitivity model of irritable bowel syndrome established by maternal infant separation combined with mechanical stimulation and drug combined with chronic stress, and discuss the advantages and disadvantages of...

2022-10-19