【Animal Modeling】-miR-144 negatively regulates the expression of TOLL-like receptor 2 in rat macrophages

To clarify the relationship between the effects of TOLL-like receptor 2 (TLR2) and microRNA144 (miR-144)...

2024-03-12

【Animal Modeling】-Mice model of lung metastasis and postoperative recurrence after bone marrow injection

Establish a model of bone marrow injection for the treatment of lung metastasis and postoperative recurrence, clarify the superiority and feasibility of the model established by bone marrow injection, and provide a new research basis for the study of...

2024-03-11

[Animal modeling] - Obesity model of small pigs induced by high sugar and high-fat diet

To investigate the effect of high fat and high sugar diet on fat distribution and blood biochemical indexes in Bama miniature pigs...

2024-03-11

[Animal modeling] - Establishment and applicability evaluation of animal model of pelvic organ prolapse

To establish a rat model that can reflect the similar pathological changes of sacral ligaments in patients with pelvic organ prolapse, and to explore the effects of increasing the intensity of birth injury and simulating menopause on the pathology of...

2024-03-11

[Animal modeling] - carbon tetrachloride induces inbred line C57BL/6 mice to establish liver fibrosis model

To compare the effects of different doses of carbon tetrachloride on the induction of liver fibrosis in inbred C57BL/6 mice, so as to establish a stable liver fibrosis model...

2024-03-11

【Animal Modeling】-Establishment of human hepatoma cell orthotopic xenograft model in mice and a comparative study of its characteristics

To select 3 strains of human hepatoma cells and inoculate them in the liver tissue of 4 different immunodeficient mice to establish and compare the orthotopic transplantation tumor models of human hepatoma cells...

2024-03-11

【Animal Modeling】-Construction of BMP-9 Gene Knockout Mice

To use CRISPR/Cas9 technology to knock out the Bmp9 gene fragment in the mouse genome to construct Bmp9 knockout mice...

2024-03-11

【Animal modeling】-Dynamic comparative study of blood and urine biochemistry between two modeling methods for kidney stones

To construct two models of renal calculi in rats, and to provide support for the exploration of the etiology of nephrolithiasis...

2024-03-11

【Animal modeling】-Effect of simvastatin PLGA sustained-release microspheres on intervertebral disc degeneration in rats

To investigate the efficacy of local injection of simvastatin PLGA sustained-release microspheres in the treatment of intervertebral disc degeneration in rats...

2024-03-11

【Animal modeling】-Effect of Roux-en-Y gastric bypass on liver and peripheral insulin sensitivity in type 2 diabetic rats

To observe the changes of insulin sensitivity in the liver and peripheral tissues of type 2 diabetic rats at different times after RYGB and to preliminarily explore the possible mechanism...

2024-03-07

【Animal modeling】-Efficacy observation and action pathway of Eucommia ulmoides extract on lipopolysaccharide-induced mastitis mice

To study the therapeutic effect and mechanism of Eucommia ulmoides extract on mastitis in mice...

2024-03-07

[Animal modeling] - Changes of C-reactive protein and inflammatory factors in the high altitude multiple organ dysfunction syndrome model of the Fenma pig

To study the tumor necrosis factor (TNF) in the high altitude multi organ dysfunction syndrome (MODS) model of pteridophyte pigs- α Interleukin-1 β And the change characteristics of C-reactive protein in the process of inflammatory reaction...

2024-03-07

【Animal Modeling】-Establishment and evaluation of a rat model of acute lung injury induced by smoke inhalation from ship fires

To establish a temperature-controllable rat model of acute lung injury induced by ship fire smoke inhalation using various composite materials as combustion materials...

2024-03-07

[Animal modeling] - Preliminary study on the effect of lipopolysaccharide on lung tissue of naked mole rats

To observe and analyze the effects of lipopolysaccharide (LPS) on the morphological structure and pathological indexes of lung tissue in nude mole rats, and to explore whether there is LPS tolerance in nude mole rats...

2024-03-07

[Animal modeling] - creating a rat model of subarachnoid hemorrhage by puncturing the internal carotid artery

To introduce in detail the method and process of making a rat subarachnoid hemorrhage model through a combination of graphics and text; Improve and innovate the model to better simulate subarachnoid hemorrhage caused by clinical aneurysm rupture...

2024-03-06

【Animal Modeling 】- Establishment of NAFLD Model in Long Clawed Gerbils and Its Genetic Study

In the post genomic era, the long clawed gerbil also needs to conduct in-depth research with new technologies in order to achieve sustainable development...

2024-03-06