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The drug lupus model commonly uses a high concentration of isopentadiene type alkane - pristane - enriched in mineral oil, and intraperitoneal injection of pristane is a standard method for obtaining enriched monoclonal antibody ascites. The use of h...
2023-09-13Adult rats were orally gavaged with Shanxi white vinegar at a dose of 10ml/kg body weight for 10 consecutive days. Observe changes in food intake, spontaneous activity, body weight, rectal temperature, stool characteristics, and general condition. On...
2023-09-13The earliest research was on PV: Dsg3 deficient mice were immunized by intraperitoneal injection of recombinant mouse Dsg3 and adjuvant. After 32 days of first immunization, 1 was removed from the spleen of the mice × After intravenous injection of 1...
2023-09-13The passive transport model of rabbit corneal autoimmune antibodies IgG was taken from patients with bullous pemphigoid (BP) and injected into the cornea of New Zealand rabbits. After 24 hours, the cornea showed epidermal detachment, thickening, and ...
2023-09-13Nude mouse model: The mice used in this model have no thymus and cellular immune deficiency, which does not cause immune rejection. If psoriasis skin lesions are transplanted into nude mice, without further intervention, the skin lesions can last for...
2023-09-13Adult rats were anesthetized, and a longitudinal incision was made in the middle of the abdomen. The bilateral renal arteries were bluntly separated. Silver clips with an inner diameter of 0.2-0.23mm were used to clamp the initial part of the bilater...
2023-09-13After fasting for 18 hours and water deprivation for 1 hour, rats were gavaged with 0.1% indomethacin 5ml/kg. The control group was given an equal amount of physiological saline...
2023-09-13Animal models related to the Stat3 pathway: Sano S et al. continuously activated the Star3 pathway by inserting the KRT5 promoter into basal keratinocytes, leading to spontaneous or psoriatic skin lesions in response to external damage, such as kerat...
2023-09-13Model rats were anesthetized by intraperitoneal injection of pentobarbital at a dose of 30mg/kg, followed by skin disinfection with iodine. After laparotomy, the stomach and upper jejunum were exposed, and the anterior stomach was fixed together with...
2023-09-13Application of propranolol to create a guinea pig ear psoriasis model. This model is commonly used in China. Huang et al. applied 5% propranolol to the ears of guinea pigs (350-400g) (0.3g of drug per cm2) twice a day for 2 weeks, while using 1% dini...
2023-09-13Animal modeling materials: Adult rats, male and female, weighing 200-250g; Drugs: 2,4-dinitrochlorobenzene, acetone, acetic acid, ethanol; Instrument: 3mm diameter nylon catheter...
2023-09-12Reproduction method: Adult rats were gavaged with 4 ℃ vinegar daily, with a volume of 10ml/kg body weight for 10 consecutive days. During this period, observe changes in animal appearance and behavior, weight, food intake, and water intake. On the da...
2023-09-12Reproduction method: Adult rats were raised in a single cage and subjected to external abdominal irradiation at a dose of 250 rad/min. The first dose was followed by a second dose of enhancement 7 days after the first dose. The changes in food intake...
2023-09-12Toll like receptor 2 gene knockout mice. In Toll like receptor 2 gene knockout mice, homozygotes can survive with normal appearance and behavior. Macrophages from mouse bone marrow cannot stimulate immune responses to lipoproteins of Borrelia burgdor...
2023-09-12Reproduction method: Adult rats were raised in a single cage, and the experimental rat cage was fixed to the oscillator using a tray. The oscillator was controlled by a relay to stop for 10 minutes every 20 minutes of vibration, with an average of 10...
2023-09-12The homozygous CD4 antigen knockout mice cannot express CD4 on the cell surface. CD8+T cells and myeloid components develop normally. This indicates that expression in ancestral cells and CD4+CD8+thymocytes is not necessary. The antiviral activity of...
2023-09-12