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【Animal Modeling】-Induced bladder cancer animal model

【Animal Modeling】-Induced bladder cancer animal model

There are two ideal animal carcinogenic chemicals: N-butyl-N-(4-hydroxybutane 1). -Nitrosamines, BBN) and N*methyl-N-nitrosourea (N-methyl-N-nitrosourea, MNU) are representative nitroso compounds and N-[4-(5 -Nitro-2-furyl)-2, -thiazolyl]carboxamide...

2023-07-03
【Animal Modeling】-Establishment of a mouse model of chronic thrombus induced by carrageenan

【Animal Modeling】-Establishment of a mouse model of chronic thrombus induced by carrageenan

To screen the conditions of chronic thrombosis mouse model by treating mice with different concentrations of carrageenan solution by continuous intraperitoneal injection...

2023-07-03
【Animal Modeling】-Effects of high-fat diet and K/BxN serum on the immune system of ApoE knockout mice

【Animal Modeling】-Effects of high-fat diet and K/BxN serum on the immune system of ApoE knockout mice

To examine the effects of high-fat diet and K/BxN serum on the distribution of immune cells in ApoE knockout (ApoE-/-) mice...

2023-06-30
【Animal modeling】-Effect of paeoniflorin on intracellular Ca2+ in rat dorsal root neurons

【Animal modeling】-Effect of paeoniflorin on intracellular Ca2+ in rat dorsal root neurons

To establish a method to evaluate the effect of paeoniflorin on the concentration of free Ca2+ in rat dorsal root ganglion neurons...

2023-06-30
【Animal modeling】-The expression characteristics of CD32 in rhesus monkey model of latent HIV infection

【Animal modeling】-The expression characteristics of CD32 in rhesus monkey model of latent HIV infection

To establish a rhesus monkey model of latent infection with SIVmac239, to study the expression characteristics of CD32 in resting, activated and/or memory CD4+ T cell subsets, and to analyze its potential as a marker of AIDS latent reservoir...

2023-06-29
【Animal Modeling】-Using a New Ultrasound Diagnostic Apparatus to Detect Cardiac Function in Rats

【Animal Modeling】-Using a New Ultrasound Diagnostic Apparatus to Detect Cardiac Function in Rats

To evaluate the cardiac function of rats by two-dimensional and M-mode echocardiography using a new type of ultrasonic diagnostic apparatus, and to understand the feasibility and accuracy of this method...

2023-06-29
【Animal Modeling】-The mechanism of miR-20a-5p regulating VEGF pathway in a mouse model of oxygen-induced retinopathy

【Animal Modeling】-The mechanism of miR-20a-5p regulating VEGF pathway in a mouse model of oxygen-induced retinopathy

To investigate the mechanism of microRNA (miR)-20a-5p regulating vascular endothelial growth factor (VEGF) pathway in mice with oxygen-induced retinopathy (OIR)...

2023-06-29
【Disease Animal Model】-Replication method of tumor model

【Disease Animal Model】-Replication method of tumor model

There are many ways to replicate animal tumors, such as irradiating laboratory animals with radiation or intravenously or locally injecting radioisotopes; using various chemical carcinogens (alkylating agents, polycyclic aromatic hydrocarbons, aromat...

2023-06-28
【Animal Modeling】-Effects of experimental intervention of normal saline on caecal microflora and short-chain fatty acid content in broilers

【Animal Modeling】-Effects of experimental intervention of normal saline on caecal microflora and short-chain fatty acid content in broilers

To study the effects of experimental intervention of normal saline on the microflora and content of short-chain fatty acids in the caecum of broilers, in order to provide a theoretical basis for the study of early microbiota intervention experiments...

2023-06-28
【Animal modeling】-Effect of botulinum toxin type A heavy chain intervention on the expression of growth-related proteins after spinal cord injury in rats

【Animal modeling】-Effect of botulinum toxin type A heavy chain intervention on the expression of growth-related proteins after spinal cord injury in rats

To investigate the effect of artificial recombinant botulinum toxin type A heavy chain (BoNT/A heavy chain) on the expression of local growth-related proteins in rats with spinal cord injury in vivo, and to provide a basis for elucidating the mechani...

2023-06-27
【Animal Modeling】-Establishment of a rat model of chronic hyperuricemia with renal damage

【Animal Modeling】-Establishment of a rat model of chronic hyperuricemia with renal damage

To provide a model tool for drug development against chronic hyperuricemia renal damage by establishing a rat model of chronic hyperuricemia renal damage...

2023-06-27
【Animal Modeling】-Preliminary exploration of evaluating drug cardiotoxicity using cardiac-specific CYP2E1 gene-modified mice

【Animal Modeling】-Preliminary exploration of evaluating drug cardiotoxicity using cardiac-specific CYP2E1 gene-modified mice

To evaluate the cardiotoxicity of the drug sibutramine using two cardiac-specific CYP2E1 gene-modified mice, and to select an animal model with higher sensitivity in evaluating the cardiotoxicity of the drug...

2023-06-27
【Animal Modeling】-Effects of intermedia and adrenomedullin on cerebral microcirculation in rats with focal cerebral ischemia

【Animal Modeling】-Effects of intermedia and adrenomedullin on cerebral microcirculation in rats with focal cerebral ischemia

To investigate the effects of intermedin and adrenomedullin on cerebral microcirculation in rats with focal cerebral ischemia...

2023-06-26
【Animal Modeling】-Preliminary Establishment of Human Brain Glioma Rat Transplantation Model

【Animal Modeling】-Preliminary Establishment of Human Brain Glioma Rat Transplantation Model

To initially establish a rat xenograft model of human glioma by using immunosuppressive agents to provide an ideal experimental tool for clinical and basic research...

2023-06-26
【Animal modeling】-Isolation and identification of mouse CD4+ T cell exosomes

【Animal modeling】-Isolation and identification of mouse CD4+ T cell exosomes

To investigate whether CD4+ T cells have the ability to secrete exosomes, and the possibility of CD4+ T cell exosomes participating in inflammation and tumor immune processes...

2023-06-25
【Animal Modeling】-Cholestatic Liver Cirrhosis Animal Model

【Animal Modeling】-Cholestatic Liver Cirrhosis Animal Model

By blocking the bile duct or injecting sclerosing agent, the extrahepatic bile duct is artificially blocked, causing the bile duct to expand above the blocked site, cholestasis, and increasing the pressure of the bile duct. I will. Intrahepatic blood...

2023-06-25