【Animal modeling】-Expression and purification of Asprosin and its effect on mouse cardiac function in vivo

To express and purify asprosin protein in prokaryotic cells of Escherichia coli, and to study its effect on the improvement of cardiac function...

2022-12-17

[Animal Modeling]-Histomorphology and pathological evaluation in miniature pig coronary artery model

The procedure for preparing blood vessel samples of stent segments is as follows. Stent segment blood vessel hard tissue sectioning and staining device: timing constant temperature electromagnetic stirrer, digital display electric heating constant te...

2022-12-17

【Animal Modeling】-Screening and application of single nucleotide polymorphism markers for identification of four commonly used strains of rats

To screen out the single nucleosides that can rapidly identify four commonly used rat strains [Wistar rat, Goto-Kakizaki (GK) rat, Brown-Norway (BN) rat, Sprague-Dawley (SD) rat] acid polymorphism sites and verify their reliability...

2022-12-17

【Animal Modeling】-Optimization of the freezing method of cynomolgus monkey semen without yolk freezing solution

Objective Due to the existence of uncertain components such as yolk in traditional sperm freezing solutions, there is a risk of biological contamination. Therefore, this study aimed to use Origio and Quinn\\\'s two commercial yolk-free cryopreservati...

2022-12-17

【Animal modeling】-Changes and significance of monocarboxylate transporter expression in rat cerebral cortex under exercise fatigue

To explore the relationship between the body\\\'s adaptability to exercise fatigue and the expression of monocarboxylate transporter in cerebral cortex...

2022-12-15

【Animal modeling】-Preparation and identification of liver-specific LCMT1 knockout mouse model

To establish a liver-specific LCMT1 knockout mouse model...

2022-12-15

【Animal Modeling】-Preliminary study of knocking out MATP gene in mouse melanoma cell line using CRISPR-Cas9 system

Use the CRISPR/Cas9 system to knock out the MATP gene in mouse melanoma cell lines, and lay the foundation for the functional study of the MATP gene...

2022-12-15

[Animal modeling] - Construction and identification of a humanized mouse model immunized with prostate cancer

To construct a humanized mouse model of immune system and transplant it into a human prostate cancer cell line for the study of immunotherapeutic drugs for prostate cancer...

2022-12-15

[Animal modeling] - Effect and mechanism of Shenqu Xiaoshi oral liquid on gastrointestinal motility in mice with functional dyspepsia

To explore the effect and mechanism of Shenqu Xiaoshi oral liquid on gastrointestinal motility in mice with functional dyspepsia (FD)...

2022-12-14

[Animal modeling] - Study on the improvement effect and mechanism of paeoniflorin on Bayk8644 induced depression and anxiety like behavior in rats

To explore the pharmacological mechanism of paeoniflorin in improving depression and anxiety like behavior in rats based on L-type voltage dependent calcium channel...

2022-12-14

[Animal modeling] - Effect of Spirillum hepaticum infection on chronic colitis model induced by dextran sodium sulfate in mice

To investigate the effect of Spirillum hepaticum infection on chronic colitis induced by dextran sodium sulfate in mice...

2022-12-14

[Animal modeling]- α- Effect of Roxnipin on Immune Function in Immunosuppressive Mice

discussion α- The effect of Roxniphyllin on the immune function of the immunosuppressive model of mice induced by cyclophosphamide provides an experimental basis for the follow-up mechanism research and the development of new drugs to increase immune...

2022-12-14

[Animal modeling] - Acupuncture can improve the symptoms of insomnia rats and affect their spontaneous activities by regulating GABA Gln metabolism

To study the effect of acupuncture on the improvement of symptoms and spontaneous activities in insomnia rats, and explore its possible mechanism...

2022-12-13

[Animal modeling] - Inhibitory effect of cytomegalovirus on some immune indexes of mice implanted with polymethylmethacrylate

To study the inhibitory effect of cytomegalovirus (CMV) on immune response of mice implanted with polymethyl methacrylate (PMMA)...

2022-12-13

[Animal modeling] - Protective effect of curcumin on acute renal injury in rats with pregnancy induced hypertension

To investigate the protective effect of curcumin on acute renal injury induced by pregnancy induced hypertension in rats and explore its potential mechanism...

2022-12-13

[Animal modeling] - Experimental study on lung tissue damage in rats caused by dental grinding dust

To evaluate the effects of cobalt chromium molybdenum metal , zirconia porcelain and polymethyl methacrylate resin on lung injury in rats...

2022-12-13