【Animal modeling】-Mechanism of transient receptor potential channel C1 in airway remodeling in guinea pig asthma and the intervention effect of budesonide

To explore the mechanism of TRPC1 ion channel in the evolution of airway remodeling and the intervention effect of budesonide by interfering with the expression of transient receptor potential channel C1 (TRPC1)...

2022-07-21

【Animal modeling】-Protective effect of Nrf2 antioxidant pathway in CCl4-induced acute liver injury in rats

To study the protective effect of Nrf2 oxidative damage pathway in CCl4-induced acute liver injury in rats...

2022-07-21

【Animal modeling】-Protective effect of Apelin-13 on focal cerebral ischemia-reperfusion injury in rats

To investigate the protective effect of Apelin-13 on focal cerebral ischemia-reperfusion injury (CIRI) in rats and its possible mechanism...

2022-07-21

【Animal modeling】-Effect of thalidomide on bisphosphonate-related osteonecrosis of the jaw

To study the effect of thalidomide on bisphosphonate-related osteonecrosis of the jaw...

2022-07-21

【Animal Modeling】-Effects of hesperidin on antioxidant activity and gene expression of antioxidant enzymes in mice

To investigate the effect of hesperidin (HDN) on the antioxidant effect of the body...

2022-07-21

【Animal modeling】-The protective effect of Zhenwu decoction on the heart of mice with uremic cardiomyopathy induced by most nephrectomy

To investigate the cardioprotective effect and mechanism of Zhenwu Decoction on uremic cardiomyopathy in mice...

2022-07-21

【Animal modeling】-Repair effect of embryonic stem cells on ischemia-damaged myocardium in pregnant mice

To investigate whether fetal rat embryonic stem cells can enter the pregnant mother through the blood circulatory system, and repair the ischemic myocardial tissue of the pregnant rat...

2022-07-21

【Animal Modeling】-Preliminary exploration of evaluating drug cardiotoxicity using cardiac-specific CYP2E1 gene-modified mice

To evaluate the cardiotoxicity of the drug sibutramine using two cardiac-specific CYP2E1 gene-modified mice, and to select an animal model with higher sensitivity in evaluating the cardiotoxicity of the drug...

2022-07-21

【Animal modeling】-The scavenging effect of arginine antidiuretic hormone on pulmonary edema in rats with acute lung injury

To investigate the effect of arginine antidiuretic hormone (AVP) on pulmonary edema fluid clearance in patients with acute lung injury...

2022-07-21

【Animal modeling】-nicotine inhibits MIA-induced apoptosis of rat osteoarthritis chondrocytes

To investigate the inhibition of nicotine on the apoptosis of osteoarthritis chondrocytes induced by sodium iodoacetate (MIA)...

2022-07-21

【Animal Modeling】-Research on the standard of abnormal toxicity of Asarum injection preparations detected by mice

To determine the LD50 value of mice intravenously administered with Asarum injection preparation, and to draft the abnormal toxicity inspection standard of this product...

2022-07-21

【Animal modeling】-Propofol protects against cerebral ischemia-reperfusion injury and may be related to the inhibition of gap junction function

To investigate the relationship between the protective effect of propofol on cerebral ischemia-reperfusion injury and gap junctions and its possible mechanism...

2022-07-21

【Animal Modeling】-Vitamin C enhances the proliferation of BMSCs derived from aging individuals in SAMP6 mice

To observe whether vitamin C (Vc) can promote the proliferation of bone marrow mesenchymal stem cells derived from aging individuals by increasing telomerase activity...

2022-07-21

【Animal modeling】-New polycitric acid filler material induces soft tissue regeneration after rat skull defect

To evaluate the ability of two novel polycitric acid degradable biomaterials to induce soft tissue regeneration after calvarial defect in rats...

2022-07-21

【Animal Modeling】-Effect of Polygoniside on the Expression Level of miR-214 and Liver Function in ApoE-/- Mice

To study the effect of polydatin (PD) on liver miR-214 and liver function in ApoE-/- mice...

2022-07-21

【Animal Modeling】-Effects of Microbial Antioxidants on Sleep and Antioxidant Properties in Mice

To explore the effects of different doses of microbial-derived antioxidants on sleep and its antioxidant properties in mice...

2022-07-21