[Animal modeling - efficacy evaluation] - induced diabetes retinopathy animal model

In diabetes, the retina is exposed to high concentration of plasma glucose, and intracellular free glucose accumulates, activating aldose reductase, the key enzyme of sorbitol metabolism. The production of sorbitol is accelerated, and sorbitol accumu...

2024-07-08

[Animal Modeling - Pharmacodynamic Evaluation] - Caries Animal Model

Caries is a progressive damage to dental hard tissue caused by a combination of factors such as bacteria, food, host, and time. If left untreated, the disease can continue to develop, leading to the formation of caries cavities and secondary pulpitis...

2024-07-08

[Animal Modeling Pharmacodynamic] Evaluation Choroidal Melanoma Animal Model

The incidence rate of choroidal melanoma in China is second only to retinoblastoma in children, and it is the most common intraocular malignant tumor in adults...

2024-07-08

[Animal Modeling - Pharmacodynamic Evaluation] - Inducing Lymphoma Animal Model

Chemically induced lymphoma animal model...

2024-07-08

[Animal Modeling Pharmacodynamic Evaluation ]- Spontaneous Leukemia Animal Model

AKR spontaneous leukemia mice are born with oncogenic RNA viruses, and their therapeutic response to drugs is similar to that of childhood acute lymphoblastic leukemia...

2024-07-08

[Animal modeling - efficacy evaluation] - induced bladder cancer animal model

There are two types of ideal chemical carcinogens to induce animal bladder cancer: nitroso compounds represented by N-butyl-N - (4-hydroxybutyl-1) - nitrosamine (BBN) and N * methyl-N-nitrosourea (MNU) and nitro compounds represented by N - [4- (5-ni...

2024-07-08

[Animal modeling - efficacy evaluation] - animal model of induced breast cancer

Inducing tumor model is the use of chemical, biological carcinogens or radiation to induce mouse tumors under certain conditions, mainly through chemical induction of tumors. The commonly used inducers are methylnitrosourea or DMBA, which are used to...

2024-07-08

[Animal modeling - efficacy evaluation] - Gene modified bladder cancer animal model

Gene modified bladder cancer animal models can be divided into microinjection method, retroviral infection method and embryonic stem cell method according to the way of gene introduction, of which microinjection method is more mature. Microinjection...

2024-07-08

[Animal modeling - Pharmacodynamic evaluation] - Mercury induced acute renal failure model in rabbits

　　After being filtered by the glomerulus, ions are reabsorbed by renal tubular epithelial cells and accumulate within the cells. They bind with the cell membrane and intracellular thiol and disulfide groups, affecting cellular enzyme activity, damagi...

2024-07-08

【Animal modeling - Pharmacodynamic evaluation 】- Animal model of renal tubulointerstitial fibrosis

Ligation of renal veins leads to renal ischemia and tubular injury, resulting in ischemic atrophy and tubular disappearance, renal interstitial hyperplasia, and renal tubulointerstitial fibrosis...

2024-07-08

【Animal modeling】-Protective effect of acupuncture combined with Danhong injection on cerebral ischemia-reperfusion injury in rats

To study whether acupuncture combined with Danhong injection has protective effect on cerebral ischemia-reperfusion injury in rats...

2024-07-05

[Animal modeling] - Chinese hamster with primary diabetes

About 10 strains of Chinese hamster diabetes model animals have been cultivated (such as inbred Chinese hamster cultivated by the Experimental Animal Center of Shanxi Medical University), some of which are severe diabetes with ketosis, some are diabe...

2024-07-05

[Animal modeling] Establishment and evaluation of an animal model of Alzheimer\\

To explore and establish a reliable animal model of Alzheimer\\\'s disease combined with phlegm and blood stasis syndrome, and to provide the corresponding animal model for the prevention and treatment of AD by traditional Chinese medicine and provid...

2024-07-05

【Animal modeling】-Effect of vitamin D deficiency on the pathogenesis of spontaneously diabetic rats

To investigate the effect of vitamin D (VD) deficiency on the pathogenesis of spontaneous diabetic rats...

2024-07-04

【Animal Modeling】-Effects of intermedia and adrenomedullin on cerebral microcirculation in rats with focal cerebral ischemia

To investigate the effects of intermedin and adrenomedullin on cerebral microcirculation in rats with focal cerebral ischemia...

2024-07-04

[Animal Modeling Pharmacodynamic Evaluation] - Establishment of Vascular Dementia Animal Model by Cerebrovascular Embolism Method

Take sterile and naturally dried blood clots of the same type of rat, grind them and pass them through a 200 μ m sieve for later use. When using, 0.5ml of physiological saline was taken and 100mg of blood clot was homogenized to form a suspension. Th...

2024-07-04