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How to prepare a rabbit model of atherosclerosis caused by high-fat and high-cholesterol diet?

How to prepare a rabbit model of atherosclerosis caused by high-fat and high-cholesterol diet?

Breeding method New Zealand rabbits weigh 2.0 to 2.5 kg and are about 3 to 4 months old. One week after observation, they are fed with 1.5% cholesterol 80 g/(kg to d) feed, free drinking water, and 12 animals per week. After feeding the animals for 1...

2020-08-06
【Animal model】-Hypertension model caused by medullary nerve compression

【Animal model】-Hypertension model caused by medullary nerve compression

Copy method After conventional anesthesia, the experimental dog was intubated, the right femoral artery was intubated, and the blood pressure was monitored by a multi-channel physiological recorder...

2020-08-06
[Dòngwù móxíng]-yìng jī xìng gāo xiěyā móxíng 15/5000 [Animal model]-Stress-induced hypertension model

[Dòngwù móxíng]-yìng jī xìng gāo xiěyā móxíng 15/5000 [Animal model]-Stress-induced hypertension model

Unconditional stimulation (epinephrine, angiotensin, electrical stimulation, etc.) is repeatedly combined with conditional stimulation to induce hypertension. This can be done by dogs, rats, rabbits and other animals...

2020-08-06
[Animal model]-Hypertension model caused by removal of baroreceptor afferent nerve

[Animal model]-Hypertension model caused by removal of baroreceptor afferent nerve

Refers to high blood pressure caused by blocking the aortic decompression nerve and carotid sinus nerve in animals. Dogs and rabbits are commonly used in experiments, sometimes rats...

2020-08-06
【Animal model】-Deoxycorticosterone (DOC) salt hypertension model

【Animal model】-Deoxycorticosterone (DOC) salt hypertension model

Feeding method Anesthetize the experimental rat, cut the midline of the abdomen, and remove the left kidney...

2020-08-06
【Animal Modeling】- Kidney Outsourcing Hypertension Model

【Animal Modeling】- Kidney Outsourcing Hypertension Model

Shèn wài yāpò xìng gāo xiěyā móxíng, liǎng gè shènzàng hé yīgè lǐngdài (yīgè shènzàng bēngdài, liǎng gè shènzàng dōu bǎoliú), yīgè shènzàng hé yīgè lǐngdài (yīgè shènzàng bēngdài, duì cè) shèn qiēchú shù), bìng jiāng liǎng gè shènzàng fēn wéi liǎng g...

2020-08-06
【Animal Model】-Renovascular Hypertension Model

【Animal Model】-Renovascular Hypertension Model

The renovascular hypertension model is a model in which the renal artery of an animal is narrowed to increase blood pressure. According to various test methods, two kidneys and one clamp type (the left renal artery is narrowed, both kidneys are retai...

2020-08-06
[Animal model]-Use rabbit brain powder extract to replicate the model of diffuse intravascular coagulation

[Animal model]-Use rabbit brain powder extract to replicate the model of diffuse intravascular coagulation

Preparation of rabbit brain powder injection: let the rabbit die, remove the rabbit brain, remove the attached blood vessels and meninges, and rinse with gauze...

2020-08-06
【Animal model】-Injection of polymer dextran plus calcium gluconate into the tail vein induces an early acute DIC model in rats

【Animal model】-Injection of polymer dextran plus calcium gluconate into the tail vein induces an early acute DIC model in rats

Breeding method About 200g male rats, after normal anesthesia, inject 1.5ml/100g body weight of 10% polymer dextran (HMWD, molecular weight 400,000) into the tail vein, and observe the microcirculation under a microscope 15-20 minutes later...

2020-08-06
[Animal model]-Tissue thromboplastin-induced rabbit acute DIC model

[Animal model]-Tissue thromboplastin-induced rabbit acute DIC model

The experimental rabbit body weight 2-3kg, tissue thromboplastin 20mg/kg body weight was administered to the rabbit ear vein, and the measurement was performed 1, 3, 6, 12, 24 hours before and after the tissue thromboplastin injection...

2020-08-06
[Animal model]-Rabbit DIC model induced by E. coli endotoxin

[Animal model]-Rabbit DIC model induced by E. coli endotoxin

Replication method Inject 250 μg of pathogenic E. coli endotoxin into a male New Zealand rabbit weighing about 2 kg through the ear vein...

2020-08-06
[Animal model]-Rabbit DIC model induced by E. coli endotoxin

[Animal model]-Rabbit DIC model induced by E. coli endotoxin

Replication method Inject 250 μg of pathogenic E. coli endotoxin into a male New Zealand rabbit weighing about 2 kg through the ear vein...

2020-08-06
[Animal model]-Balloon injury to the aorta to form thrombus

[Animal model]-Balloon injury to the aorta to form thrombus

Replication method After regular anesthesia, the experimental rabbits were fixed and the femoral artery and vein were separated. Draw 20 ml of blood through femoral vein cannula and label platelets with 51 Cr...

2020-08-06
[Animal model]-Balloon injury to the aorta to form thrombus

[Animal model]-Balloon injury to the aorta to form thrombus

Replication method After regular anesthesia, the experimental rabbits were fixed and the femoral artery and vein were separated. 20 ml of blood was drawn through the femoral vein cannula, and platelets were labeled with 51 Cr. Inject the labeled plat...

2020-08-06
How to prepare an animal model of autologous arterial thrombosis?

How to prepare an animal model of autologous arterial thrombosis?

After the rabbit model is normally anesthetized, the experimental rabbit is fixed in the supine position, and the femoral artery puncture tube is connected to the pressure monitor. Isolate the abdominal aorta, clamp both ends of the abdominal aorta w...

2020-08-06
How to prepare an animal model of pulmonary heart disease induced by ferric chloride?

How to prepare an animal model of pulmonary heart disease induced by ferric chloride?

Replication method For experimental rabbits, slowly inject 1 to 1.5 ml of 1% FeCl3 aqueous solution through the ear vein, and spray 0.5 ml of cadmium chloride aqueous solution on the rabbit’s throat every 3 days....

2020-08-06