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At present, it is believed that the cause of BCC is mainly related to the abnormal activation of the Shh signaling pathway (sonichedgehog signaling pathway, Shh)...
2020-08-04![[Animal model]-Spontaneous basal cell carcinoma model](/./uploads/images/20200804/5f2907a64841f.jpg)
Basal cell carcinoma (BCC) may be derived from primitive epithelial germ cells and is mainly composed of mesenchymal-dependent pluripotent basal-like cells. It is a low-grade malignant tumor that differentiates into the epidermis or accessory organs....
2020-08-04UV-induced melanoma model, some species will develop UV-induced melanoma lesions based on a specific genetic background...
2020-08-04Certain species may spontaneously develop melanoma lesions due to their specific genetic background...
2020-08-04Transgenic mice are valuable tools to determine the physiological functions of specific genes or proteins and their role in pathology. From a unique point of view that helps to study the cause of the disease, various transgenic mice exhibit disease c...
2020-08-04Peroxide Hydrogen peroxide, hydroquinone, monobenzophenone and other skin bleaching agents are used to artificially cause animal bleaching and simulate the pathological symptoms of vitiligo...
2020-08-04Some animals (chickens, rodents, dogs, cats, horses, etc.) can locally cause pigmentation. There are many anti-melanocyte antibodies in these animals, the most commonly used are Smith Line (SL) chickens and C57BL mice...
2020-08-04The specific cause of psoriasis has not been fully clarified, but more and more evidence supports the role of T lymphocytes in it...
2020-08-04Due to uncontrolled and massive proliferation of osteoblasts, osteosarcoma is the most common type of bone tumor...
2020-08-04Nude mice are usually inoculated with tumor mass or cells subcutaneously, and the tumor continues to grow. It can simulate the process of human malignant tumors. The tumor formation rate is high, the tumor formation time is uniform, and the tumor siz...
2020-08-04Allogeneic transplantation refers to the process of transplanting to animals of the same species or the same family. The organisms between the donor and the recipient have a high degree of commonality, and can stay in the body, grow and proliferate, ...
2020-08-04Naphthalene can increase the reactive oxygen species in rabbit cells, increase the generation of free radicals, and increase the peroxidation damage, resulting in damage to the lipid of the lens cell membrane and causing experimental cataracts...
2020-08-03In diabetes, the retina is exposed to high concentrations of plasma glucose. Free glucose accumulates in cells and activates aldose reductase, which is the main enzyme for sorbitol metabolism, promotes sorbitol production, and stimulates retinal capi...
2020-08-03Induction of retinal diseases, drugs or physical methods are used to change the structure of the retina, resulting in a disease similar to human retinitis pigmentosa. The operation of the animal model of RP disease induced by physical and chemical fa...
2020-08-03The Royal College of Surgeons (RCS) rat is an animal model of autosomal recessive inheritance. CS rat retinal pigment epithelial cells (retinal pigment epithelium, RPE) express genes that cannot swallow discrete patches. This leads to the loss of pho...
2020-08-03Dry eye disease, also known as dry cornea and conjunctiva, is one of the most common diseases in ophthalmology. It can cause ocular surface damage or impaired vision and affect the quality of life of patients. At present, in most patients, the cause ...
2020-08-03