[Animal modeling] - establishment of a mouse model of skin adverse reactions induced by erlotinib

Erlotinib is a novel targeted drug for the treatment of non-small cell lung cancer. It has been widely used in clinical practice in recent years, but has many side effects, with rash being the most common and difficult for patients to accept...

2024-03-02

[Animal Modeling] - Establishment of an Infectious Model of Coxsackie Virus A16 and Evaluation of Related Immunological Indicators and Applications

To establish a simple and reliable small rodent experimental animal model sensitive to Coxsackie virus A16 type...

2024-03-02

[Animal Modeling] - Validation and Regularity Exploration of Establishing a Hyperlipidemia Model with High Fat Diet Feeding

To establish hyperlipidemia in SD rats fed with a high-fat diet for 8 weeks, verify the feasibility of the modeling method, and explore the changes in blood lipids of rats at different time points...

2024-03-02

[Animal Modeling] - Application Progress of Targeted Gene Modification Technology in Immunodeficiency Animal Model Research

　　Immunodeficiency animal models have important applications in human related disease mechanism research, drug development, organ transplantation research, and stem cell research...

2024-03-02

[Animal Modeling] - Application of Gene Modified Animal Models to Study the Progress of Depression

Depression is a complex mental disease with polygene inheritance. Its incidence rate is high, and the serious cases are accompanied by suicide...

2024-03-02

[Animal modeling] - Establishment of a mouse model of abdominal aortic aneurysm and analysis of its histological characteristics

To establish an abdominal aortic aneurysm model in C57BL/6J mice by perfusion of porcine trypsin and evaluate its pathological changes...

2024-03-01

【Animal modeling】-Establishment and application of multiplex PCR method for four pathogens in experimental animals

To establish a multiplex PCR method for the rapid detection of four experimental animal pathogens, Pasteurella multocida, Bordetella bronchiscus, Mycoplasma and Klebsiella pneumoniae...

2024-03-01

【Animal modeling】- PERV-env gene cloning and tissue expression profiling in Guangxi Bama miniature pigs

To clone part of PERV-env gene of Guangxi Bama miniature pig, and study its expression difference in different tissues...

2024-03-01

【Animal Modeling】-Relationship between the expression of vitamin D metabolizing enzyme CYP24A1 in testis of adult tree shrew and fertility

To study the transcript levels of vitamin D metabolizing enzymes and vitamin D receptors in the testis of adult tree shrew, detect the protein expression of CYP24A1, and explore the causes of reproductive disorders in male experimental tree shrew...

2024-03-01

【Animal modeling】-Effect of knockout TRPC6 on MPTP-induced neuroinflammatory injury in mice

To detect the expression of TRPC6 channel in microglia in a mouse MPTP-induced neuroinflammation model, and to explore the effect of TRPC6 channel on inflammatory expression and dopaminergic neuron damage...

2024-03-01

[Animal modeling] Anesthetic effect of compound doses of Shutai and Lumianning on Bama miniature pigs

To study the anesthetic effect of Shutai and Lumianning combined anesthesia on Bama mini pigs, and to observe the effect of anesthesia on physiological indexes of mini pigs...

2024-03-01

【Animal Modeling】-Comparison of Two Hepatitis B Hepatitis B Fibrosis Mouse Compound Models

To use C57BL/6N-Tg(1.28HBV)/Vst hepatitis B virus transgenic mice and rAAV8-1.3HBV adeno-associated virus-transfected mice combined with CCl4 intraperitoneal injection to induce hepatitis B fibrosis mouse model, and compare the two mice Virological a...

2024-03-01

【Animal Modeling】-Depression-like behavioral changes in male and female rats induced by restraint stress of different durations

To investigate the effects of chronic restraint stress of different restraint durations on the depression-like behavior of male and female SD rats, and to provide a basis for the selection of experimental animals\\\\\\\' gender and experimental durat...

2024-03-01

[Animal modeling] - Construction and evaluation of two models of obese polycystic ovary syndrome with insulin resistance in rats

To establish an animal model of obese polycystic ovary syndrome (PCOS) with insulin resistance by two different ways combined with high-fat diet, and compare its endocrine and metabolic characteristics...

2024-03-01

【Animal modeling】-Comparative study on bone growth in rats after long-term exposure to low-fluoride aluminum and short-term high-fluoride aluminum exposure

To observe the effects of different doses of fluoride and aluminum combined with the duration of intake on longitudinal bone growth and bone metabolism in rats...

2024-02-29

【Animal modeling】-Behavioral differences in learning and memory ability of C57BL/6J, BALB/c, ICR strain mice

To compare the behavioral differences of learning and memory ability of C57BL/6J, BALB/c and ICR strain mice...

2024-02-29