Effects of adenovirus-mediated shRNA targeting NF-κB gene on the proliferation activity of cynomolgus monkey endometrial cells in vitro

Synthesize a highly specific shRNA adenovirus vector targeting the NF-κB gene, and observe whether it directly inhibits the proliferation of cynomolgus monkey endometrial cells cultured in vitro...

2021-01-25

【Animal Modeling】-The effect of dexamethasone pollution in drinking water on the intestinal flora of mice

　　To explore the effect of dexamethasone pollution in the water environment on the intestinal flora of mice...

2021-01-25

[Animal modeling]-Pathological changes of amyloid cerebrovascular disease in Alzheimer\'s disease rats

On the basis of establishing an experimental rat model of Alzheimer\'s disease...

2021-01-25

【Animal Modeling】-Edaravone can reduce oxidative stress and delay myocardial fibrosis in rats

To explore the effect of edaravone on reducing oxidative stress and anti-myocardial fibrosis...

2021-01-25

To explore the regulatory effect of human interferon-α (IFN-α) gene transformation on the immune function of mice after oral administration of bifidobacteria

To explore the regulatory effect of human interferon-α (IFN-α) gene transformation on the immune function of mice after oral administration of bifidobacteria...

2021-01-25

Effects of rapid eye movement sleep deprivation on anxiety behavior and hippocampal nitric oxide levels in adolescent and adult C57BL/6J mice

To study the effects of 24-hour rapid eye movement sleep (REMS) deprivation on anxiety behavior and hippocampal nitric oxide (NO) levels in adolescent and adult C57BL/6J mice...

2021-01-25

【Animal modeling】-Src kinase inhibitor PP2 protects rat astrocytes from hypoxia/reoxygenation injury

To study the protective effect of Src kinase inhibitor PP2 on hypoxia/reoxygenation injury of rat astrocytes...

2021-01-25

【Animal Modeling】-Lentivirus-mediated ACE2 overexpression affects the albumin expression and migration ability of rat hepatocytes induced by angiotensin Ⅱ

To explore the inhibitory effect of angiotensin converting enzyme 2 (ACE2) on the over-regulation of hepatocyte albumin expression induced by angiotensin II (Ang II) and enhance cell migration...

2021-01-25

Effect of alcohol exposure during pregnancy on basic rhythmic respiratory discharge in medulla oblongata of newborn rats

To explore the effect of drinking during pregnancy on the basic rhythmic respiratory discharge activity (RRDA) of the medulla oblongata slices in the offspring of newborn rats...

2021-01-25

High-intensity focused ultrasound inhibits the metastasis of mouse melanoma cells B16-F10 in vivo

To explore the effect of high intensity focused ultrasound (HIFU) treatment on the metastasis of melanoma cells in the mouse model of melanoma...

2021-01-22

Schistosoma japonicum recombinant Bb (pGEX-Sj32) vaccine induces the dynamic changes of BALB/c mouse splenocyte proliferation, subpopulation and cytokine

Observe the dynamic changes of the immune response of mouse spleen cells induced by the recombinant Bb vaccine of Schistosoma japonicum, and study its immune mechanism...

2021-01-22

【Animal Modeling】-The role of KA1 subreceptors in the death of hippocampal neurons caused by endoplasmic reticulum stress

To explore the role of up-regulation of KA1 receptor in the death of hippocampal neurons caused by endoplasmic reticulum stress...

2021-01-22

【Animal Modeling】-Effect of electroacupuncture on the expression of ankle joint myeloid cells in acute gouty arthritis rats to stimulate receptor expression

To explore the effect of electroacupuncture on the expression of stimulatory receptor (TREM)-1 in bone marrow cells of ankle synovial tissue in rats with acute gouty arthritis (AGA)...

2021-01-22

[Animal modeling]-Chloroquine inhibits airway hyperresponsiveness in asthmatic mice

To explore the effect of chloroquine on airway hyperresponsiveness in asthmatic mice and its possible mechanism...

2021-01-22

[Animal modeling]-The role of advanced glycation end product receptors in lipopolysaccharide-mediated changes in the cytoskeleton of mouse lung microvascular endothelial cells

Establish a method for isolating high-purity pulmonary microvascular endothelial cells, and observe the wild-type mouse cells and receptors in knockout mice with high glycation end products stimulated by lipopolysaccharide...

2021-01-22

【Animal Modeling】-Minocycline inhibits hyperpolarization activation currents of glial neurons in the spinal dorsal horn of rats

To study the effect of minocycline on the hyperpolarization activation current (Ih) of glial neurons in the posterior horn of the spinal cord in rats...

2021-01-22