[Animal modeling - Pharmacodynamic evaluation] - A model of acute liver injury induced by concanavalin A

Cona bean protein A can activate the proliferation of CD8+or CD4+cells, increase the release of IFN - γ, which promotes the infiltration of inflammatory cells into the hepatic portal vein area and activates the comprehensive response of M phi functio...

2024-07-01

[Animal Modeling Pharmacodynamic Evaluation ]-Thyroidectomy Animal Model of Kidney Yang Deficiency Syndrome

Adult rats were anesthetized, with skin incision, muscle dissection, bilateral thyroid separation and excision, and muscle and skin suturing. Observe the general condition of rats, test left ventricular function and thyroid function, euthanize animal...

2024-07-01

Animal Modeling Pharmacodynamic Evaluation Sex Hormone Application Method Animal Model of Kidney Yang Deficiency Syndrome

Select female rat offspring born at the same time period for selective breeding. On the 8th day of age, female rats were subcutaneously injected with testosterone propionate at a dose of 1.25mg/animal in the neck and back, and weaned on the 22nd day ...

2024-07-01

Animal Modeling Pharmacodynamic Screening Rabbit Pneumonia Model

Escherichia coli is seeded on a nutrient agar slope and stored in a refrigerator at 4 ℃. Before use, it is picked up with an inoculation ring on a sterile operating table and transferred to a regular broth medium. It is incubated at 37 ℃ for 48 hours...

2024-07-01

【Animal Modeling】-Polyethylene oxide improves blood perfusion of chronic ischemic hindlimb in rats

To evaluate the effect of polyethylene oxide (PEO) on improving blood perfusion of chronic ischemic hindlimb in rats by contrast echocardiography...

2024-07-01

【Animal modeling】-An easy-to-operate method for the isolation and culture of mouse hepatocytes

To optimize an easy-to-operate, fast and practical method to obtain mouse hepatocytes on the basis of traditional hepatocyte extraction methods, and to provide an improved experimental method reference for researchers engaged in liver function...

2024-07-01

【Animal modeling】-Changes of IL-6, SOD and MDA in the lung tissue of rats with acute pulmonary edema

To investigate the changes and significance of malondialdehyde, superoxide dismutase and interleukin-6 in lung tissue of acute hypoxia-induced acute pulmonary edema in rats...

2024-07-01

【Animal modeling】-Establishment and application of a method for detecting the copy number of porcine endogenous retrovirus based on droplet digital PCR technology

To optimize the detection method of porcine endogenous retrovirus copy number in pig genome by using droplet digital PCR technology, and to establish a detection method for PERV copy number...

2024-07-01

【Animal Modeling】-Diversity of intestinal flora of oriental vole under laboratory and field conditions

To investigate the distribution and differences of intestinal flora of oriental voles under laboratory and field conditions...

2024-07-01

【Animal modeling】-Establishment and application of immunocomb detection method for simian immunodeficiency virus antibody

To prepare the SIV30 protein of simian immunodeficiency virus (SIV) by genetic engineering technology as an antigen diagnostic reagent, and to establish an immunocomb method (IC) for the specific detection of anti-SIV antibody IgG in the serum of exp...

2024-07-01

【Animal Modeling】-Pathological Study of Spontaneous Hepatobiliary Hyperplasia in Aged Rats

To accumulate valuable research data on rat hepatic bile duct hyperplasia for related scientific research and new drug safety evaluation...

2024-07-01

【Animal Modeling】-Immune mechanism of systemic lupus erythematosus MRL/lpr mice

To investigate the immune mechanism of MRL/lpr mice with systemic lupus erythematosus at different months of age, and to provide a basis for the study of its pathogenesis...

2024-07-01

【Animal Modeling】-Establishment of basic data of embryo-fetal developmental toxicity test in Bama miniature pigs

To detect the reproductive function indicators and fetal developmental indicators of the embryo-fetal developmental toxicity test in Bama miniature pigs, and to provide reference data for the developmental toxicity study of Bama miniature pigs...

2024-07-01

【Animal Modeling】-Effect of SEL1L gene deletion in central neurons on mouse behavior

To explore the role of endoplasmic reticulum protein SEL1L in maintaining normal physiological activities of mammalian central nervous system...

2024-07-01

[Animal modeling] - Inhibitory effect of cytomegalovirus on some immune indexes of mice implanted with polymethylmethacrylate

To study the inhibitory effect of cytomegalovirus (CMV) on immune response of mice implanted with polymethyl methacrylate (PMMA)...

2024-07-01

【Animal Modeling】-The damage characteristics of olfactory working memory in the very early stage of Alzheimer\\

To investigate the characteristics of olfactory working memory impairment in the very early stage of Alzheimer\\\'s disease transgenic mice...

2024-07-01