[Animal modeling ]- B6-hIGHMBP2 mouse model provides a new approach for the study of neuronal diseases

On January 23, 2024, Vanda Biopharmaceuticals (VNDA) announced that its antisense nucleotide (ASO) drug VCA-894A targeting the IGHMBP2 gene has officially received FDA approval for a new drug clinical trial (IND)...

2024-02-26

[Animal Modeling] - Construction and Evaluation of a Chemotherapy induced Venous Phlebitis Rat Model Induced by Vinorelbine

To construct an animal model and evaluation system of chemotherapy-induced phlebitis induced by injection of Changchun Ruibin injection into the dorsal foot vein of rats...

2024-02-26

[Animal Modeling] - Establishment and Evaluation of a Constipated Irritable Bowel Syndrome Model with Liver Depression Syndrome

Single factor modeling method and multi factor combined modeling method were used to prepare rat models of liver depression syndrome constipation type irritable bowel syndrome (IBS-C). By comparing different indicators, an ideal IBS-C experimental an...

2024-02-26

【 Animal Modeling 】 - Evaluation of Syndrome in a Tidal Heat Model Rat Induced by Bilateral Ovariectomy and Tamoxifen Administration

To explore a syndrome animal model for studying women\'s hot flashes...

2024-02-26

[Animal Modeling] - New Progress in Aging Models of Rodents

Aging is a degenerative process that occurs over time, and age-related diseases are closely related to aging...

2024-02-26

[Animal Modeling] - Application of Gene Modified Animal Models to Study the Progress of Depression

Depression is a complex mental disease with polygene inheritance. Its incidence rate is high, and the serious cases are accompanied by suicide...

2024-02-26

[Animal modeling]- doxorubicin induced cardiomyopathy model

Doxorubicin is a commonly used cycle non-specific anti-tumor chemotherapy drug in clinical practice. While anti-tumor, it also forms superoxide free radicals, destroys cell membrane structure and function. Its mechanism of myocardial toxicity is to p...

2024-02-18

[Animal Modeling] - Electrical Stimulation Induced Ventricular Arrhythmia Model

Electrical stimulation can change the membrane conductivity of myocardial cells, increase the heterogeneity of myocardial repolarization, and make the stimulation more prone to fibrillation during the vulnerable period. The ventricular fibrillation t...

2024-02-18

[Animal Modeling] - Acute Myocardial Ischemia and Atrial Fibrillation Model

Acute ischemia delays the conduction of impulses in the ischemic area of the atrium, making it easier for reentry to form and leading to the occurrence of atrial fibrillation...

2024-02-18

[Animal Modeling] - Homologous Immune Liver Injury Model

Healthy adult guinea pigs, weighing 250-400g, regardless of gender; Medication: Freund\'s complete adjuvant; Instrument: homogenizer...

2024-02-18

[Animal Modeling] - Heterologous Immune Liver Injury Model

hybrid rats or mice, newly weaned male purebred mice; Medication: Freund\'s complete adjuvant; Equipment: High speed freezer centrifuge, homogenizer...

2024-02-18

[Animal modeling] - carbon tetrachloride induced rabbit liver cirrhosis model

Healthy 3-month-old New Zealand white rabbits, weighing (1.8 ± 0.2) kg; Medications: Full price nutritional pellet rabbit feed, CCl4, olive oil, edible ethanol...

2024-02-18

[Animal Modeling] - Carbon Tetrachloride Cirrhosis Animal Model

Wistar or SD rats, weighing around 180-200g; Medication: 40% to 50% carbon tetrachloride oil solution, 20% to 30% alcohol, pure corn flour (mixed with 0.5% cholesterol)...

2024-02-18

[Animal Modeling] - Macaque Liver Fibrosis Model

macaques, male, aged 7-10 years old, weighing 8-10kg; Drug: Analytical pure CCl4...

2024-02-18

[Animal modeling] - Pingyangmycin iodine oil emulsion induced liver fibrosis model

Animal: 4-5 month old Japanese white rabbits with large ears, regardless of gender, weighing (2.5 ± 0.2) kg; Medication: Pingyangmycin iodine oil emulsion...

2024-02-18

[Animal modeling] - Animal model of radiation injury with blood stasis syndrome

Adult mice were placed in a 60Co organic glass light box γ Radiation source illumination, height 80cm, whole body illumination of 6.0Gy, dose rate of 1.15Gy/min. Three days after irradiation, the mouse was euthanized due to cervical dislocation. The ...

2024-02-18