【Animal modeling】-Effect of low selenium diet on the expressions of CD163, CD206 and CCR7 in the liver and kidney of rats

To investigate the effect of low selenium diet on liver and kidney in rats, and the role of macrophage polarization to M1 and M2 in liver and kidney fibrosis...

2023-03-16

【Animal modeling】The effect of -1α,25(OH)2D3 on the expression of lubricin in rat articular chondrocytes

To investigate the effect of 1α,25(OH)2D3 on the synthesis and secretion of lubricin in chondrocytes at the cellular level...

2023-03-16

【Animal modeling】-Effect of modified Wuzhuyu decoction on hypertension and vascular endothelial function in rats induced by high sugar, high fat and alcohol consumption

To investigate the effect of modified Wuzhuyu Decoction on blood pressure and vascular endothelial function in hypertensive model rats induced by high-sugar and high-fat diet and drinking...

2023-03-16

【Animal Modeling】-Establishment and theoretical application of liver dual arterial blood supply model

To establish a stable and high-success rate rat model of 70% hepatectomy with dual hepatic arterial blood supply under the microscope...

2023-03-15

【Animal Modeling】-Experimental study of CD45 mAb-mediated 188Re-avidin two-step pretargeting targeting lymphoma

To establish a CD45 mAb-mediated two-step pre-localization method for 188Re-avidin, observe its biological distribution in tumor-bearing mice, and evaluate its feasibility in the treatment of lymphoma...

2023-03-15

【Animal Model】-Effect of β-arrestin2 gene knockout on the function of mouse peritoneal macrophages

To investigate the effect of β-arrestin2 gene knockout on the function of mouse peritoneal macrophages...

2023-03-15

【Animal modeling】-The role and mechanism of miR-221 in H2O2-induced myocardial cell injury in rats

To investigate the role and mechanism of miR-221 in hydrogen peroxide (H2O2)-induced myocardial cell injury in rats...

2023-03-14

【Animal Modeling】-Depression-like behavioral changes in male and female rats induced by restraint stress of different durations

To investigate the effects of chronic restraint stress of different restraint durations on the depression-like behavior of male and female SD rats, and to provide a basis for the selection of experimental animals\\\' gender and experimental duration ...

2023-03-14

【Animal Modeling】-Establishment of a rat model of chronic hyperuricemia with renal damage

To provide a model tool for drug development against chronic hyperuricemia renal damage by establishing a rat model of chronic hyperuricemia renal damage...

2023-03-13

【Animal modeling】-Preliminary study on the myocardial injury model of rhesus monkeys induced by isoproterenol

To explore the method of using isoproterenol to induce myocardial injury in rhesus monkeys...

2023-03-13

[Animal modeling]-Establishment of real-time fluorescent quantitative PCR method for mouse hepatitis virus and its application in some rodents

Establish a real-time fluorescent quantitative PCR method to detect mouse hepatitis virus (MHV), and first use it to detect experimental nude mice and other rodents...

2023-03-13

【Animal modeling】-Experimental study on the differentiation of bone marrow mesenchymal stem cells into cardiomyocyte-like cells induced by Jiawei Danshen Decoction in vitro

To investigate the experimental study on the differentiation of bone marrow mesenchymal stem cells into cardiomyocyte-like cells induced by Modified Danshen Decoction in vitro...

2023-03-10

【Animal modeling】-Metformin regulates the effect of miR-34a on airway inflammation in COPD rats

To investigate the effect of metformin (Met)-regulated microRNA (miR)-34a on airway inflammation in rats with chronic obstructive pulmonary disease (COPD)...

2023-03-10

【Animal Modeling】-Observation of some physiological indicators of rhesus monkeys using implanted telemetry technology

To observe the circadian variation of physiological indicators such as respiration, blood pressure, ECG, and body temperature in awake rhesus monkeys with implanted telemetry technology and changes during stress...

2023-03-10

【Animal modeling】-Protective effect and mechanism of pine bark extract on cerebral ischemia-reperfusion injury in mice

To investigate the neurotherapeutic effect and mechanism of IL-6/STAT3/miR-21 in pine bark extract on cerebral ischemia-reperfusion injury in mice...

2023-03-09

【Animal Modeling】-Based on a systematic review of pathomorphology to explore the differences between porcine coronary balloon injury lesions and atherosclerosis

The histomorphological characteristics of porcine coronary artery balloon injury lesions were analyzed through a systematic review, and compared with the histomorphological characteristics of human atherosclerotic plaques, in order to provide a basis...

2023-03-09