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【Animal Modeling】-Effect of continuous multiple application of propofol and vitamin C on anesthesia in mice

【Animal Modeling】-Effect of continuous multiple application of propofol and vitamin C on anesthesia in mice

To investigate the anesthesia effect of propofol or propofol combined with vitamin C on mice for 6 consecutive days...

2023-03-09
【Animal Modeling】-Effect and mechanism of propofol intervention on optic nerve injury in rats

【Animal Modeling】-Effect and mechanism of propofol intervention on optic nerve injury in rats

To investigate the effect and mechanism of propofol intervention on the injured optic nerve and retinal ganglia after optic nerve injury in rats...

2023-03-09
【Animal Modeling】- Establish a humanized mouse model of cytotoxic T lymphocyte-associated antigen 4 (CTLA4) gene, which provides an effective mouse model for the development and screening of tumor the

【Animal Modeling】- Establish a humanized mouse model of cytotoxic T lymphocyte-associated antigen 4 (CTLA4) gene, which provides an effective mouse model for the development and screening of tumor the

To establish an animal model suitable for evaluating the efficacy of traditional Chinese medicine compound and new drug development for ulcerative colitis with damp-heat syndrome, and to explore the difference and relationship between common ulcerati...

2023-03-09
【Animal modeling】-Comparative study on the induction of specific CD8+ T cell immune responses in C57BL/6 mice infected with influenza A virus H1N1pdm09 and PR8

【Animal modeling】-Comparative study on the induction of specific CD8+ T cell immune responses in C57BL/6 mice infected with influenza A virus H1N1pdm09 and PR8

To compare the two subtypes of influenza A virus H1N1 strains A/Shanghai/37T/2009(H1N1)(pdm09) clinical isolates and A/PuertoRico/8/34(H1N1)(PR8) standard strains infected with C57BL/6 small Changes in the pathological state and the induction of immu...

2023-03-09
【Animal modeling】-The improvement effect of treadmill exercise on the motor function of elderly rats

【Animal modeling】-The improvement effect of treadmill exercise on the motor function of elderly rats

To investigate the change rule of rat motor function with increasing age, and the improvement effect of exercise on the motor function of elderly rats....

2023-03-08
【Animal modeling】-Using Matrigel to block the portal vein to establish an improved ALPPS surgery mouse model

【Animal modeling】-Using Matrigel to block the portal vein to establish an improved ALPPS surgery mouse model

To establish a modified two-step hepatectomy mouse model with liver partition and portal vein ligation independent of microsurgical techniques, and to verify its effectiveness in stimulating liver regeneration...

2023-03-08
【Animal modeling】-Optimization of in vivo chromosomal aberration test in ICR mice

【Animal modeling】-Optimization of in vivo chromosomal aberration test in ICR mice

To carry out in vivo chromosomal aberration experiments in ICR mice, by administering cyclophosphamide and colchicine at different time points, to compare the effects of different administration/collection time points and different administration con...

2023-03-08
【Animal Modeling】-Methodological comparative analysis of orthotopic and subcutaneous PDX models of hepatocellular carcinoma

【Animal Modeling】-Methodological comparative analysis of orthotopic and subcutaneous PDX models of hepatocellular carcinoma

To construct orthotopic and subcutaneous human tumor xenograft models of hepatocellular carcinoma, and to compare and analyze the growth and pathological characteristics of the two models...

2023-03-08
【Animal Modeling】-Effect of Protein Phosphatase 5 (PP5) on Fat Metabolism in Mice

【Animal Modeling】-Effect of Protein Phosphatase 5 (PP5) on Fat Metabolism in Mice

To explore the role of PP5 in fat metabolism in mice using protein phosphatase 5 (PP5) knockout mice...

2023-03-07
【Animal modeling】-Exploration of the effect of pomegranate tonic syrup on anemia in Wistar rats

【Animal modeling】-Exploration of the effect of pomegranate tonic syrup on anemia in Wistar rats

To investigate the effect of pomegranate tonic syrup on anemia in Wistar rats...

2023-03-07
【Animal Modeling】-Comparison of the ability of rat adipose stem cells and bone marrow mesenchymal stem cells to differentiate into endothelium

【Animal Modeling】-Comparison of the ability of rat adipose stem cells and bone marrow mesenchymal stem cells to differentiate into endothelium

To study the ability of adipose stem cells (ASCs) to differentiate into endothelium and compare with bone marrow mesenchymal stem cells (BMSCs)...

2023-03-06
【Animal Modeling】-B-ultrasound-guided biopsy method of rhesus monkey liver and kidney tissue

【Animal Modeling】-B-ultrasound-guided biopsy method of rhesus monkey liver and kidney tissue

To establish a safe and effective method for obtaining liver and kidney samples by in vivo puncture of rhesus monkeys under the guidance of B-ultrasound...

2023-03-06
【Animal Modeling】-Construction and identification of an immunohumanized mouse model of prostate cancer

【Animal Modeling】-Construction and identification of an immunohumanized mouse model of prostate cancer

To construct a mouse model of humanized immune system and transplant it into human prostate cancer cell lines, so as to be used for the research of prostate cancer immunotherapy drugs...

2023-03-04
【Animal modeling】-Optimization of SD rat skin chemical hair removal parameters based on D-optimal design

【Animal modeling】-Optimization of SD rat skin chemical hair removal parameters based on D-optimal design

To study the depilation parameters of SD rat skin, and to provide basic experimental conditions for establishing skin photoaging animal model...

2023-03-04
【Animal modeling】-Influence of RNA interference inhibition of Beclin1 gene on proliferation and apoptosis of naked mole rat fibroblasts

【Animal modeling】-Influence of RNA interference inhibition of Beclin1 gene on proliferation and apoptosis of naked mole rat fibroblasts

To inhibit the expression of autophagy-regulating gene Beclin 1 by RNA interference technology, and to detect the effect of Beclin 1 expression on the proliferation and apoptosis of naked mole rat skin fibroblasts and the expression of p53, BAX, Bcl2...

2023-03-04
【Animal modeling】-Effect of alprostadil on eIF2α/ATF4/CHOP pathway and liver function in fulminant liver failure rats

【Animal modeling】-Effect of alprostadil on eIF2α/ATF4/CHOP pathway and liver function in fulminant liver failure rats

To investigate the effect of alprostadil (PGE1) on liver function in rats with fulminant liver failure (FHF), and to investigate its effect on eukaryotic translation initiation factor 2α (eIF2α) / activating transcription factor 4 (ATF4) / C/ EBP Reg...

2023-03-04