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【Animal modeling】-Establishment and application of immunocomb detection method for simian immunodeficiency virus antibody

【Animal modeling】-Establishment and application of immunocomb detection method for simian immunodeficiency virus antibody

To prepare the SIV30 protein of simian immunodeficiency virus (SIV) by genetic engineering technology as an antigen diagnostic reagent, and to establish an immunocomb method (IC) for the specific detection of anti-SIV antibody IgG in the serum of exp...

2022-05-25
【Animal Modeling】-Screening of microsatellite primers for experimental marmosets and analysis of genetic diversity

【Animal Modeling】-Screening of microsatellite primers for experimental marmosets and analysis of genetic diversity

To screen and optimize marmoset microsatellite DNA primers for genetic analysis and evaluation of the experimental marmoset population introduced by the Institute of Medical Laboratory Animals, Chinese Academy of Medical Sciences...

2022-05-25
【Animal modeling】-Analysis of biological parameters and cardiac physiological function in mice overexpressing Slit2 gene

【Animal modeling】-Analysis of biological parameters and cardiac physiological function in mice overexpressing Slit2 gene

To measure and evaluate the basic biological parameters, cardiac ultrasound morphology and function, and transcriptome sequencing of human Slit2 gene overexpressing mice (Slit2-Tg mice), so as to provide reference for the application of this mouse in...

2022-05-25
【Animal modeling】-Changes and characteristics of three types of CD molecules and IFN-γ expression in tree shrew infected with reovirus

【Animal modeling】-Changes and characteristics of three types of CD molecules and IFN-γ expression in tree shrew infected with reovirus

To investigate the characteristics of tree shrew reovirus-induced immune changes, and to provide theoretical basis for virus prevention in tree shrew...

2022-05-25
【Animal Modeling】-Transcranial ultrasound perfusion imaging performance and safety evaluation in rats after skull thinning

【Animal Modeling】-Transcranial ultrasound perfusion imaging performance and safety evaluation in rats after skull thinning

To observe and quantitatively evaluate the performance of right brain transcranial ultrasound perfusion imaging by thinning the local skull of SD rats to improve the acoustic window, and to preliminarily evaluate the effect of bone grinding and trans...

2022-05-25
【Animal Modeling】-A comparative study of in situ liver cancer dynamic imaging and pathology in nude mice

【Animal Modeling】-A comparative study of in situ liver cancer dynamic imaging and pathology in nude mice

To dynamically monitor tumor growth in nude mice after orthotopic liver cancer modeling and to compare it with pathology, so as to determine the appropriate period of intervention therapy...

2022-05-25
【Animal Modeling】-Screening and application of single nucleotide polymorphism markers for identification of four commonly used strains of rats

【Animal Modeling】-Screening and application of single nucleotide polymorphism markers for identification of four commonly used strains of rats

To screen out the single nucleotide polymorphisms that can rapidly identify four commonly used rat strains [Wistar rat, Goto-Kakizaki (GK) rat, Brown-Norway (BN) rat, Sprague-Dawley rat] sex, site and verify its reliability...

2022-05-25
【Animal Modeling】-Analysis of fecal microbial diversity of wild tree shrews using Illumina MiSeq sequencing platform

【Animal Modeling】-Analysis of fecal microbial diversity of wild tree shrews using Illumina MiSeq sequencing platform

To analyze the structure and composition of the fecal flora of wild tree shrew by high-throughput sequencing technology, and to lay a foundation for the further development and utilization of this new experimental animal...

2022-05-25
【Animal modeling】-Experimental study on growth and reproduction of Tlr4 knockout mice

【Animal modeling】-Experimental study on growth and reproduction of Tlr4 knockout mice

To study the similarities and differences in growth and reproduction between Tlr4 knockout mice and KM mice...

2022-05-25
【Animal modeling】-Experimental study on puerarin alleviating radiation-induced acute intestinal mucosal injury in rats

【Animal modeling】-Experimental study on puerarin alleviating radiation-induced acute intestinal mucosal injury in rats

To study the protective effect of puerarin on the intestinal mucosal injury of SD rats induced by radiation and its molecular mechanism...

2022-05-19
【Animal Modeling】-Preliminary study on the mechanism of hypoxic preconditioning reducing the susceptibility to epilepsy and its brain protective effect in rats

【Animal Modeling】-Preliminary study on the mechanism of hypoxic preconditioning reducing the susceptibility to epilepsy and its brain protective effect in rats

To preliminarily investigate the effect of intermittent hypoxic preconditioning on epileptic seizures in rats induced by lithium chloride and pilocarpine and its brain protective mechanism...

2022-05-19
【Animal modeling】-Effect of PLCζ on oocyte fertilization and embryonic development after injection of mouse round spermatids

【Animal modeling】-Effect of PLCζ on oocyte fertilization and embryonic development after injection of mouse round spermatids

To investigate the feasibility of PLCζ as an activator and its effect on oocyte fertilization and embryonic development after ROSI...

2022-05-19
【Animal Modeling】-Discussion on the Sequence Scheme of Reducing Image Respiration and Heartbeat Artifacts in In vivo Thoracic Scanning of Rats

【Animal Modeling】-Discussion on the Sequence Scheme of Reducing Image Respiration and Heartbeat Artifacts in In vivo Thoracic Scanning of Rats

To develop a sequence that reduces image breathing and heartbeat artifacts in 256-slice spiral CT rat in vivo chest CT scans...

2022-05-19
【Animal Modeling】-Exploration on the Application of Automatic Control Technology System of Laboratory Animal Barrier Facility System

【Animal Modeling】-Exploration on the Application of Automatic Control Technology System of Laboratory Animal Barrier Facility System

To realize the stable operation of the experimental animal barrier system, research and explore the automatic control technology of the experimental animal barrier system...

2022-05-19
【Animal modeling】-plasma lipidomic characteristics of spontaneously obese rhesus monkeys

【Animal modeling】-plasma lipidomic characteristics of spontaneously obese rhesus monkeys

The increasing prevalence of obesity is becoming a medical and public health concern as obesity is closely associated with metabolic abnormalities including hyperlipidemia, nonalcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D) and cardiovas...

2022-05-18
【Animal Modeling】-Efficacy and safety of electroacupuncture combined with methylprednisolone on intervertebral disc prolapse in rats

【Animal Modeling】-Efficacy and safety of electroacupuncture combined with methylprednisolone on intervertebral disc prolapse in rats

To observe the effects of electroacupuncture combined with methylprednisolone and electroacupuncture or methylprednisolone alone on limb motor function and neuronal Nissl bodies in a rat model 24 hours after intervertebral disc prolapse, and to provi...

2022-05-18