【Animal Modeling】-High-throughput sequencing method to study the effect of different pH drinking water on the gut microbes of SPF mice

To study the effect of drinking water with different pH values on the intestinal microbial diversity of SPF mice...

2021-07-20

[Animal Modeling]-Preparation of rat thoracic aorta vascular smooth muscle cells by an improved two-step compound enzyme digestion method

This article reports an improved method for isolating rat thoracic aortic vascular smooth muscle cells based on complex enzyme digestion....

2021-07-20

【Animal Modeling】-Hydrogen-rich liquid reduces cerebral ischemia-reperfusion injury in rats through PI3K pathway

To investigate the effect of hydrogen-rich liquid on hippocampal neuron apoptosis and PI3K/Akt/FoxO1 signal pathway expression induced by cerebral ischemia-reperfusion in rats...

2021-07-20

【Animal Modeling】-Comparison of the effect of calcium chelated collagen peptide and estrogen on the bone quality of ovariectomized rats

To compare the bone-improving effects of calcium chelated collagen polypeptide (CPCC) and estrogen, and lay the foundation for the development of safe osteoporosis (OP) prevention and treatment drugs...

2021-07-20

【Animal Modeling】-Deoxyvioletin inhibits the proliferation of colon cancer TH29 cells and induces apoptosis and its mechanism

To investigate the inhibitory effect of deoxyionization on the proliferation and inducing apoptosis of human colon cancer HT29 cells and its possible mechanism...

2021-07-20

【Animal Modeling】-Guanxinning Tablet Protects Myocardial Ischemia-Reperfusion Injury

To observe the effects of Guanxinning tablets (GXNT) on myocardial infarction and cardiac autonomic nerve function in rats with myocardial ischemia reperfusion injury (MI/RI)...

2021-07-20

【Animal Modeling】-The effect of bacitrin on experimental autoimmune encephalomyelitis in mice

Observe the effects of different concentrations of baicalin on experimental autoimmune encephalomyelitis mouse models, and preliminarily explore its mechanism of action...

2021-07-19

【Animal Modeling】-The effect of self-made Gehua Jiejiu Dizhi Decoction on liver fat deposition and PXR expression in alcoholic fatty liver mice

Understand the effect of homemade Gehua Jiejiu Dizhi Decoction on liver fat deposition in alcoholic fatty liver (AFLD) mice, and observe its effect on liver tissue pregnane receptor (PXR) and its regulatory target genes CYP3A11 and CYP3A25 protein mR...

2021-07-19

【Animal Modeling】-Sequential Observation of Acute Kidney Injury Induced by Cisplatin in Rabbits

To explore the course of acute kidney injury (AKI) in rabbits caused by a single intravenous injection of cisplatin...

2021-07-19

[Animal Modeling]-Changes of blood biochemical index levels in rats with chronic alcoholic liver injury after transplantation of human amniotic membrane mesenchymal stem cells

Studies have shown that human amniotic membrane mesenchymal stem cells have a variety of differentiation and proliferation functions, induce differentiation into liver-like cells, thereby resisting liver damage...

2021-07-19

【Animal Modeling】-Pharmacokinetics Study of Granisetron Hydrochloride Transdermal Patch in Beagle Dogs with Multi-dose Administration

Establish a method to determine the blood concentration of Beagle dog granisetron transdermal patch, clarify the pharmacokinetic changes of Beagle dog granisetron transdermal patch after multiple administrations, provide dynamic characteristics and I...

2021-07-19

【Animal Modeling】-DS-1226 Improves Depressive Behavior of Mice Caused by Chronic Sleep Disturbance

To study the antidepressant effect of ginsenoside hydrolysate DS-1226 on mice with chronic sleep disorders, and provide a scientific basis for the development of antidepressants...

2021-07-19

【Animal Modeling】-Study on the mechanism of trace element strontium in improving non-alcoholic fatty liver in rats

To explore the mechanism of the trace element strontium in improving non-alcoholic fatty liver in rats...

2021-07-19

【Animal Modeling】-The effect of neural stem cell-specific LSD1 gene knockout on mood and memory in mice

By conditionally knocking out the LSD1 gene in mouse neural stem cells, observe the proliferation of mouse nerve cells and mouse behavior, and clarify the neurobiological function of LSD1...

2021-07-19

【Animal Modeling】-The effect of androgen deficiency on visceral fat accumulation and inflammatory gene expression in miniature pigs under high-fat environment

To study the effects of androgen deficiency on visceral fat deposition, serum hormones and inflammation-related gene expression in miniature pigs in a high-fat environment...

2021-07-19

【Animal Modeling】-The influence of Labrador Retriever’s behavior and heart rate changes on the success rate of guide dog training in distance test

Use the distance test (DT) to evaluate the behavior and heart rate characteristics of Labrador dogs, and provide effective behavioral methods and physiological basis for the pre-screening of guide dogs...

2021-07-19