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![[Animal modeling - Pharmacodynamic evaluation] - Sucrose induced hypertensive rat model](/./uploads/images/default/default.png)
Due to high sugar intake, SD rats can develop insulin resistance and hyperinsulinemia, leading to an increase in blood pressure. The possible mechanism of the latter is: ① insulin induced sodium water retention; ② Stimulating sympathetic nervous syst...
2024-07-01After animal anesthesia, the common carotid artery is surgically separated and a right ventricular catheter is inserted. A brain pressure gauge is connected to measure ventricular pressure, and an amplifier can also be connected to monitor intracrani...
2024-07-01After anesthesia, the animal is placed in a supine position and a 5cm incision is made at the midline of the neck to expose the right common carotid artery, separate the internal carotid artery, ligate the collateral branch that did not enter the sku...
2024-07-01The animal in the modeling group underwent surgery to expose the left parietal bone. A bone hole with a diameter of 5.0mm was drilled along the midline of the sagittal suture and 1.5mm behind the coronal suture, exposing the dura mater. The lower end...
2024-07-0136 New Zealand white rabbits with large ears, 18 in the experimental group and 18 in the control group. On the 1st to 5th day of the experiment, daily intravenous injection of 440mg/m2 of cytarabine was administered to the ear margin, and immunosuppr...
2024-07-01Cats can be used as a cardiogenic shock model when their blood pressure drops below half of the normal value due to slow femoral vein injection of 3% pentobarbital under the anesthesia and artificial respiration conditions of Ultan...
2024-07-01Adult SD rats were instilled with Aspergillus fumigatus suspension through tracheal intubation to establish a rat lung infection model. The suspension of Aspergillus fumigatus was inoculated into the rats through nasal and oropharyngeal instillation ...
2024-07-0112 week old male Wistar rats, weighing 250-300g; Medication: Anesthetics; Instruments: rat stereotactic device, miniature electrocoagulation knife, electric pulse random stimulation device...
2024-07-01This model is commonly used in China. Huang et al. applied 5% propranolol to the ear of guinea pigs (350-400g) and 0.3g of the drug (1cm2) twice a day for 2 consecutive weeks. At the same time, 1% dinitrochlorobenzene (DNCB) and 1% croton oil castor ...
2024-07-01Adult rats, regardless of gender, weighing 250-400g; Medications: physiological saline, formaldehyde...
2024-07-01Adult rats were stimulated with sulfur dioxide at a dose of (200-250) x 10 to the power of -5, for 1 hour per day and continuous stimulation for 13 days. Cold wind stimulation was used with a temperature 5 ℃ lower than the living environment temperat...
2024-07-01Put 20-50g/L of degraded carrageenan solution into a bottle for guinea pigs to drink, record the amount of water the guinea pigs drink, and add sucrose at a rate of 50g/L to increase palatability...
2024-07-01Female BALB/c mice (H-2 gene phenotype), aged 8-10 weeks at the time of use; Reagents and antibodies: Hamster anti mouse CD3 monoclonal antibody, fluorescein isothiocyanate (FITC) labeled anti mouse CD45RB monoclonal antibody, phycoerythrin (PE) labe...
2024-07-01Closed group small pigs, weighing 15.5-43.0kg, 2-3 months old, with similar body weights for both donors and recipients, regardless of gender. They were fasted for 24 and 6 hours before surgery, and water was prohibited. They were randomly divided in...
2024-07-01Adult rabbits were fixed on a rabbit platform, and a lever pressure device was used to apply 7.5kg of pressure on the inner thigh muscle of the right hind limb for 1.5 hours. The changes in muscle temperature, leg diameter, hind limb blood flow, conj...
2024-07-01Prepare a BCG vaccine solution with physiological saline to contain 10 times the power of live bacteria per milliliter, and inject 0.2ml (2.5mg) of BCG vaccine solution through the tail vein. 10 days later, 0.2ml (10 μ g) of LPS physiological saline ...
2024-07-01