【Animal modeling】-Construction and effect evaluation of Noggin gene silencing expression vector

To construct lentivirus-mediated Noggin RNAi interference sequences, and to analyze the silencing effect of these interference sequences on Noggin gene...

2023-12-18

【Animal Modeling】-Discuss the pharmacodynamic effect and preliminary mechanism of action of oxymatrine, the active ingredient in Sophora flavescens, in the treatment of atopic dermatitis mice

To observe the chronic toxicity of Deinococcus radiodurans R1 to SD rats...

2023-12-18

【Animal Modeling】-Effect of solitary rearing on the behavior of rat model of post-traumatic stress disorder established by a single prolonged stress

To establish a model of post-traumatic stress disorder by single prolonged stress, and to observe the effect of solitary rearing on SPS model rats...

2023-12-18

【Animal modeling】-Relevant mechanism of hypertonic saline protecting blood-brain barrier and reducing cerebral edema in rats with cerebral hemorrhage

To investigate the related mechanism of hypertonic saline treatment in reducing cerebral edema in rats with cerebral hemorrhage...

2023-12-18

【Animal modeling】-The protective effect of etomidate on acute lung injury in septic shock rats based on TLR4 pathway

To investigate the protective effect of etomidate (Eto) on acute lung injury in rats with septic shock based on the Toll-like receptor 4 (TLR4) pathway...

2023-12-18

【Animal Modeling】-Construction of an experimental autoimmune myasthenia gravis mouse model using the black-spotted double-fin electric ray

To establish an experimental autoimmune myasthenia gravis animal model that meets international preclinical experimental standards...

2023-12-18

【Animal modeling】-Effect of dexmedetomidine pretreatment on inflammatory factors and oxidative stress in rats with septic kidney injury

To investigate the effect of dexmedetomidine on inflammatory factors and oxidative stress of AKI (acute kidney injury) in septic rats...

2023-12-18

[Animal modeling] - Establishment of tree shrew model of Fusarium solani keratitis

To establish a tree shrew model of Fusarium solanacearum keratitis by infecting the cornea of tree shrews with clinically isolated Fusarium solanacearum...

2023-12-18

【Animal modeling】-Effect of fibrinolytic system on podocyte injury in rats with membranous nephropathy

To investigate the importance of early prevention of fibrinolytic disorder in preventing the progression of MN...

2023-12-18

【Animal Modeling】-The role of cAMP/CREB/BDNF signaling pathway in vortioxetine against depression-like behavior in mice

To study the effect of vortioxetine, a novel antidepressant, on cyclic adenosine monophosphate/cyclic adenosine monophosphate response element binding protein/brain-derived neurotrophic factor (cAMP/CREB/BDNF) signal transduction pathway...

2023-12-16

【Animal Modeling】-Effect of Metformin on Learning and Memory Ability in Mice Aging

To explore the effect and possible mechanism of metformin supplementation on the learning and memory ability of mice during the aging process of D-galactose-induced mice...

2023-12-16

【Animal Modeling】-Establishment and evaluation of a rat model of acute lung injury induced by smoke inhalation from ship fires

To establish a temperature-controllable rat model of acute lung injury induced by ship fire smoke inhalation using various composite materials as combustion materials...

2023-12-15

[Animal modeling] - Establishment of rat models of acute and chronic salpingitis infertility caused by Staphylococcus aureus

To establish acute and chronic salpingitis infertility models in rats by using Staphylococcus aureus...

2023-12-15

【Animal modeling】-New polycitric acid filler material induces soft tissue regeneration after rat skull defect

To evaluate the ability of two novel polycitric acid degradable biomaterials to induce soft tissue regeneration after calvarial defect in rats...

2023-12-14

【Animal modeling】-Study on coagulation function of rat sepsis model

To investigate the changes of coagulation function in a rat model of sepsis induced by cecal ligation and puncture...

2023-12-14

【Animal modeling】-Dynamic comparative study of blood and urine biochemistry between two modeling methods for kidney stones

To construct two models of renal calculi in rats, and to provide support for the exploration of the etiology of nephrolithiasis...

2023-12-14