[Animal Modeling] - Establishment and Evaluation of a Constipated Irritable Bowel Syndrome Model with Liver Depression Syndrome

Single factor modeling method and multi factor combined modeling method were used to prepare rat models of liver depression syndrome constipation type irritable bowel syndrome (IBS-C). By comparing different indicators, an ideal IBS-C experimental an...

2024-02-26

【 Animal Modeling 】 - Evaluation of Syndrome in a Tidal Heat Model Rat Induced by Bilateral Ovariectomy and Tamoxifen Administration

To explore a syndrome animal model for studying women\'s hot flashes...

2024-02-26

[Animal Modeling] - New Progress in Aging Models of Rodents

Aging is a degenerative process that occurs over time, and age-related diseases are closely related to aging...

2024-02-26

[Animal Modeling] - Application of Gene Modified Animal Models to Study the Progress of Depression

Depression is a complex mental disease with polygene inheritance. Its incidence rate is high, and the serious cases are accompanied by suicide...

2024-02-26

【Animal Modeling】-Characteristics of cardiac structure and function pathological process in a mouse model of pressure overload heart failure

To establish a mouse model of heart failure, and to comprehensively evaluate the characteristic changes of cardiac function and structure during the development of the disease by using ultrasound imaging and pathological techniques...

2024-02-23

【Animal Modeling】-Preliminary Study on the Changes of Tongue Gene Expression Profile in Rats with Qi Stagnation and Blood Stasis Syndrome

To study the changes of the whole gene expression profile in the tongue of rats with qi stagnation and blood stasis syndrome and the biological processes and pathways involved in differential genes by using gene chip technology, in order to provide s...

2024-02-23

【Animal modeling】-Establishment of a mouse model of salt-sensitive hypertension

To establish a mouse model of salt-sensitive hypertension, and use the antihypertensive drug nifedipine to verify the validity of the model....

2024-02-23

【Animal Modeling】-How to establish an animal model of pelvic organ prolapse?

Establish a rat animal model that can reflect similar pathological changes of similar ligaments in patients with pelvic organ prolapse, and explore the effects of increased birth injury intensity and menopausal simulation on the pathology of rat bone...

2024-02-23

[Animal modeling] - Based on autophagy, explore the effect of fentanyl combined with propofol on myocardial ischemia-reperfusion injury in rats

To investigate the effect of fentanyl combined with propofol on myocardial ischemia-reperfusion injury in rats based on autophagy...

2024-02-23

[Animal modeling] - Construction and evaluation of humanized mouse model of pancreatic cancer immune system

To construct and evaluate a humanized mouse model of pancreatic cancer immune system in order to provide an ideal preclinical model for immunotherapy of pancreatic cancer...

2024-02-23

【Animal modeling】-Effect of ligustrazine on extracellular regulated protein kinase pathway in collagen-induced arthritis rats

To investigate the effect of ligustrazine on extracellular regulated protein kinase pathway in collagen-induced arthritis rats...

2024-02-23

【Animal Modeling】-Analysis of Factors Affecting the Production Efficiency of Bacterial Artificial Chromosome Transgenic Mice

To compare several key factors in the development of bacterial artificial chromosome transgenic mice, such as the genetic background of experimental mice, BAC plasmid injection concentration, BAC plasmid fragment size and BAC injection storage time,...

2024-02-22

【Animal modeling】-Directed editing of mouse MAD2L1 gene based on CRISPR/Cas9 system and analysis of its off-target effect

To establish a method system for gene editing of the second exon of mouse MAD2L1 gene using CRISPR/Cas9 system, and to analyze the off-target effect of CRISPR/Cas9 on MAD2L1 gene editing...

2024-02-22

[Animal modeling] - 3D reconstruction of lungs and 3D printing model of vessels in miniature pigs

To explore the method of 3D reconstruction model of miniature pig lung and the application of 3D printing model...

2024-02-22

【Animal Modeling】-Possible Mechanism of Exogenous β-NGF in Regulating the Process of Bone Remodeling

To explore the possible mechanism of exogenous β-NGF on bone remodeling during bone defect healing...

2024-02-22

[Animal modeling] - Effect of long-term high protein diet on liver steatosis and fat accumulation in OVX mice

To investigate the effects of long-term high protein diet on liver and adipose tissue of ovariectomized mice and the role of glucagon like peptide-1...

2024-02-22