![[Animal Modeling - Efficacy Evaluation] - Choline free Ethylthionine Feed Induced Animal Model](/./uploads/images/default/default.png)
In 1975, Lomobardi et al. established a female mouse model of acute hemorrhagic necrotizing pancreatitis by feeding a choline deficient diet supplemented with ethionine...
2024-08-02![[Animal Modeling Drug Efficacy Evaluation] - Traditional Induced Hepatitis B Virus Animal Model](/./uploads/images/default/default.png)
At present, animal models of hepatitis B virus mainly include tree shrew hepatitis B model, duck hepatitis B model, marmot hepatitis B model, and mouse hepatitis B model...
2024-08-02![[Animal Modeling Drug Efficacy Evaluation] - Hepatitis E Virus Rhesus Monkey Model](/./uploads/images/default/default.png)
Hepatitis E is mainly transmitted through the fecal oral route (digestive tract), while other routes include blood transmission and vertical transmission...
2024-08-02![[Animal modeling - efficacy evaluation] - Gene modified pancreatic cancer animal model](/./uploads/images/default/default.png)
In the process of early diagnosis and treatment of pancreatic cancer, it is found that the precancerous lesions of pancreatic cancer, pancreatic intraductal epithelioma, molecular genetic abnormalities, are directly related to pancreatic cancer...
2024-08-02![[Animal Modeling - Efficacy Evaluation] - Transgenic Animal Liver Cancer Model](/./uploads/images/default/default.png)
By using genetic engineering methods to introduce specific exogenous genes into the genome of animals, they can undergo integration, genetic reproduction, and thus cultivate animals carrying exogenous genes...
2024-08-02![[Animal Modeling - Pharmacological Evaluation] - Implantable Liver Cancer Animal Model](/./uploads/images/default/default.png)
A liver cancer model formed by transplanting liver cancer tissue, cell lines, or other malignant tumors derived from animals or humans into animal bodies in the future...
2024-08-02![[Animal Modeling - Pharmacological Evaluation] - Induced Liver Cancer Animal Model](/./uploads/images/default/default.png)
Induced liver cancer animal model refers to the use of chemical, physical, and biological carcinogenic factors on experimental animals to simulate the cyclic changes of liver injury fibrosis malignant transformation, and induce the formation of liver...
2024-08-02![[Animal Modeling - Pharmacological Evaluation ]- Ischemic Acute Renal Failure Animal Model](/./uploads/images/default/default.png)
Removing the right kidney and clipping the left renal artery causes ischemic mitochondrial dysfunction in the kidney, resulting in the production of a large amount of hypoxanthine. Under hypoxic conditions, hypoxanthine cannot be metabolized into xan...
2024-08-01![[Animal Modeling - Pharmacological Evaluation] - Rat Chronic Obstructive Pulmonary Disease Model](/./uploads/images/default/default.png)
Chronic obstructive pulmonary disease (COPD) is a chronic respiratory system disease characterized by airflow limitation, with inflammation as the core. It is related to abnormal inflammatory responses of the lungs to harmful gases or particles such ...
2024-08-01![[Animal Modeling - Pharmacological Evaluation] - Norepinephrine Induced Cardiomyopathy Model in Rabbits](/./uploads/images/default/default.png)
Injecting high-dose norepinephrine into rabbits increases myocardial load, causes myocardial degeneration and necrosis, leading to the occurrence of DCM and congestive heart failure...
2024-08-01
rabbits, weighing 2-2.5kg, sheep; Drug: Complete Freund\'s adjuvant...
2024-08-01![[[Animal Modeling - Pharmacological Evaluation] - Animal Model of Qi Deficiency and Blood Stasis Syndrome after Cerebral Infarction (Stroke)](/./uploads/images/default/default.png)
Cerebral infarction belongs to the category of \"stroke\" in traditional Chinese medicine and is a serious disease that threatens human health. Qi deficiency and blood stasis are one of its important pathological mechanisms. The methods for...
2024-08-01
In 1997, Hiroshi Matsuda from the Faculty of Agriculture at Tokyo A&M University in Japan first reported a mouse model of Nc/Nga that spontaneously produced AD phenotype...
2024-08-01![[Animal Modeling - Pharmacological Evaluation] - Choroidal Melanoma Animal Model](/./uploads/images/default/default.png)
The incidence rate of choroidal melanoma in China is second only to retinoblastoma in children, and it is the most common intraocular malignant tumor in adults...
2024-08-01![[Animal Modeling Drug Efficacy Evaluation] - Canine Orthodontic Wire Ligation with Mechanical Injury Periodontitis Animal Model](/./uploads/images/default/default.png)
The clinical characteristics of periodontitis mainly include gingival inflammation, periodontal pocket formation, alveolar bone resorption, and tooth loosening and displacement. Among them, how to prevent further alveolar bone resorption and promote ...
2024-08-01![[Animal Modeling - Pharmacological Evaluation] - Ovarian Resection Induced Osteoporosis Animal Model](/./uploads/images/default/default.png)
Primary osteoporosis includes postmenopausal osteoporosis and senile osteoporosis, mainly characterized by decreased bone mass, degeneration of bone microstructure, decreased bone strength and increased fragility, and susceptibility to fractures. The...
2024-08-01