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[Animal modeling - Drug efficacy evaluation] - Establishment of periodontitis model through dietary habits

[Animal modeling - Drug efficacy evaluation] - Establishment of periodontitis model through dietary habits

Adult golden hamsters were fed with Keyes 2000 formula feed (56% fructose, 28% skimmed milk powder, 6% flour, 4% yeast, 3% alfalfa flour, 1% animal liver powder, 2% salt) and a small amount of vegetables. After 6 weeks, microscopic histopathological ...

2024-08-27
[Animal Modeling Drug Efficacy Evaluation] - Recurrent Oral Ulcer Animal Model

[Animal Modeling Drug Efficacy Evaluation] - Recurrent Oral Ulcer Animal Model

Firstly, place the dialysis bag in a 0.5mol/L EDTA solution, boil for 0.5 hours, discard the solution, replace with distilled water and boil again 3 times. Then store it in distilled water containing 0.01% sodium azide and store it at 4 ℃ for future ...

2024-08-27
[Animal Modeling - Pharmacological Evaluation] - Oral Ulcer Animal Model

[Animal Modeling - Pharmacological Evaluation] - Oral Ulcer Animal Model

SD rats weighing 150-180g. Take a 6cm long glass tube with a diameter of 3mm at the lower end, and insert a small cotton ball inside. Make the bottom of the small cotton ball level with the lower opening of the glass tube, and then drip 90% carbolic ...

2024-08-27
[Animal Modeling - Pharmacological Evaluation] - Mercury Raising Induced Kidney Disease Model in Rabbits

[Animal Modeling - Pharmacological Evaluation] - Mercury Raising Induced Kidney Disease Model in Rabbits

male rabbits weighing 2-2.5kg; Drug: mercuric chloride...

2024-08-27
[Animal Modeling - Pharmacological Evaluation] - Rabbit Oleic Acid Type Acute Lung Injury Model

[Animal Modeling - Pharmacological Evaluation] - Rabbit Oleic Acid Type Acute Lung Injury Model

Healthy rabbits, male or female, weighing 2.0-2.5kg; Medications: Oleic acid, pentobarbital, heparin physiological saline...

2024-08-27
[Animal Modeling - Pharmacological Evaluation] - Pingyangmycin induced Lung Injury Model in Rats

[Animal Modeling - Pharmacological Evaluation] - Pingyangmycin induced Lung Injury Model in Rats

Healthy SD rats, male or female, weighing (210 ± 23) g; Drug: Pingyangmycin, physiological saline; Instrument: Syringe...

2024-08-27
[Animal modeling - Drug efficacy evaluation] - Serum nephritis model

[Animal modeling - Drug efficacy evaluation] - Serum nephritis model

rabbit; Drug: Bovine serum albumin (BSA)...

2024-08-27
【Animal Modeling - Pharmacological Evaluation】 - Cationized Bovine Serum Albumin Nephritis Model in Rabbits

【Animal Modeling - Pharmacological Evaluation】 - Cationized Bovine Serum Albumin Nephritis Model in Rabbits

rabbits, weighing 2-2.5kg; Drug: Cationized bovine serum albumin (C-BSA)...

2024-08-27
[Animal Modeling - Efficacy Evaluation] - Carbon Tetrachloride Induced Cirrhosis Animal Model

[Animal Modeling - Efficacy Evaluation] - Carbon Tetrachloride Induced Cirrhosis Animal Model

Adult male rats were intraperitoneally injected with 2ml/kg body weight of 30% CCl4 paraffin oil solution twice a week for 7 consecutive weeks...

2024-08-26
[Animal Modeling - Pharmacological Evaluation] - Ethanol Induced Liver Fibrosis Model

[Animal Modeling - Pharmacological Evaluation] - Ethanol Induced Liver Fibrosis Model

Adult rats were given Baijiu (ψ (C2H5OH)=0.56) 7g/kg body weight by gavage once a day in the morning for 24 weeks. Or give Baijiu corn oil pyrazole mixture by gavage once a day in the morning for 12 consecutive weeks...

2024-08-26
【Animal modeling - Drug efficacy evaluation】 - Induction of liver fibrosis model by common bile duct ligation method

【Animal modeling - Drug efficacy evaluation】 - Induction of liver fibrosis model by common bile duct ligation method

Adult rats were anesthetized and their abdominal cavity was opened to locate and free the common bile duct in the mesentery of the descending duodenum. Two silk threads were threaded underneath and a \"V\" - shaped incision was made towards...

2024-08-26
【Animal Modeling - Pharmacological Evaluation】 - Liver Resection Induced Liver Failure Animal Model

【Animal Modeling - Pharmacological Evaluation】 - Liver Resection Induced Liver Failure Animal Model

Adult rats were anesthetized by intraperitoneal injection of ether or ketamine at a dose of 100mg/kg body weight, fixed in a supine position, and opened along a transverse incision in the upper abdomen. The abdominal wall blood vessels were cauterize...

2024-08-26
[Animal modeling drug efficacy evaluation] - Ethanol gavage plus high-fat feeding model

[Animal modeling drug efficacy evaluation] - Ethanol gavage plus high-fat feeding model

Adult rats were fed a high-fat diet (supplemented with 1% cholesterol and 5% lard on top of a low-fat diet) for one week after normal feeding. At the same time, they were orally administered with 1.5ml/kg body weight of 60% ethanol twice a day for 12...

2024-08-26
[Animal modeling - Drug efficacy evaluation] - Intestinal adhesion animal model

[Animal modeling - Drug efficacy evaluation] - Intestinal adhesion animal model

Adult rats were fasted and deprived of water for 12-16 hours. After intraperitoneal injection of pentobarbital sodium at a dose of 40mg/kg body weight, the rats were anesthetized and placed supine on a surgical plate. The abdomen was routinely depila...

2024-08-26
[Animal Modeling - Pharmacological Evaluation]- Fetal Mouse Colonic Implantation Induced Ulcerative Colitis Animal Model

[Animal Modeling - Pharmacological Evaluation]- Fetal Mouse Colonic Implantation Induced Ulcerative Colitis Animal Model

Adult SD rats, aged 5-6 months and weighing 250-400g, were implanted with a colon of 3-4cm under the right renal capsule of 14-16-day-old homologous fetal rats. On postoperative days 7, 14, and 21, 5-10ml of cardiac blood was extracted for the separa...

2024-08-26
【Animal Modeling Drug Efficacy Evaluation】 - Escherichia coli Immunoassay Ulcerative Colitis Animal Model

【Animal Modeling Drug Efficacy Evaluation】 - Escherichia coli Immunoassay Ulcerative Colitis Animal Model

Adult rats received four immunizations on the 1st, 10th, 17th, and 24th days. The immune substance is a suspension of Escherichia coli cells killed by formaldehyde, with a concentration of 1.2 × 100000000/ml. Preparation method: Take one rat, euthani...

2024-08-26