[Animal modeling - Drug efficacy evaluation] - Animal infection model of Burkholderia mallei

Selecting albino guinea pigs as experimental subjects, the bacterial suspension was intraperitoneally inoculated into guinea pigs at a dilution of 2 × 10000000 CFU/ml...

2024-09-23

[Animal modeling - efficacy evaluation] - Pathological mechanism of conjunctival injury in diabetes model rabbits

By detecting the matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) in conjunctival tissue cells of diabetes rabbits fed with high-fat and high-sugar diet plus streptozotocin, the relationship between them and...

2024-09-23

[Animal modeling - efficacy evaluation] - animal model of diabetes caused by partial pancreatectomy

SD rats were intraperitoneally injected with a 5% pentobarbital sodium physiological saline solution at a dose of 40-50 mg/kg body weight. The rats were fixed in a dorsal position on a surgical plate, and their abdomen was shaved and disinfected with...

2024-09-23

[Animal Modeling Drug Efficacy Evaluation] - Preparation of Tree Shrew Hepatitis B Animal Model

Ten tree shrews were used. For the first time, 0.5ml of serum (1 × 10 ^ 8 CID, chimpanzee infection dose) was intravenously injected from two asymptomatic human carriers of hepatitis B virus. Three days later, an equal amount of the same human serum ...

2024-09-23

[Animal modeling - Drug efficacy evaluation] - Rabbit conjunctivitis model induced by bufotalin tincture

Bufalin tincture has strong irritant properties and can stimulate the conjunctiva of rabbit eyes, causing certain degree of damage, thus replicating the acute irritant conjunctivitis model in rabbits...

2024-09-23

[Animal Modeling Drug Efficacy Evaluation] - Establishment of Vascular Dementia Animal Model by Cerebral Embolism Method

Take sterile naturally dried blood clots from the same type of rats, grind them and sieve them through a 200 μ m sieve for later use. When applied, take 0.5ml of physiological saline and 100mg of blood clot homogenate to prepare a suspension. Measure...

2024-09-23

[Animal modeling - efficacy evaluation] - establishment of diabetes animal model after total pancreatectomy

Adult hybrid dogs weighing 10-15kg, intramuscular injection of 30mg/kg body weight of 3% pentobarbital sodium, tracheal intubation. One side of the femoral artery and vein were respectively intubated to measure arterial pressure and collect blood sam...

2024-09-23

[Animal Modeling - Pharmacological Evaluation] - Acanthamoeba Keratitis Model

Acanthamoeba keratitis is a rare and severe chronic progressive corneal disease...

2024-09-23

[Animal Modeling - Pharmacological Evaluation] - Acute Compression Animal Model of Lumbar Nerve Root

Adult healthy New Zealand white rabbits, with an average weight of 2.3kg, half male and half female; Medications: 10% chloral hydrate, 75% alcohol, iodine, penicillin...

2024-09-23

[Animal Modeling - Pharmacological Evaluation]- Rat Sciatic Nerve Clamp Injury Model

　　Surgery was performed under intraperitoneal anesthesia with pentobarbital (0.4mg/kg) and sterile conditions. A longitudinal incision was made on the lateral side of the left lower limb of the animal, and a specially designed vascular clamp was used...

2024-09-23

[Animal Modeling Drug Efficacy Evaluation] - Preparation of Doxorubicin Mouse Cardiomyopathy Model

Wistar rats were intraperitoneally injected with doxorubicin at a dose of 2.5mg/(kg · time), 3 times per week, with an interval of 2 weeks, followed by 1 week for a total of 6 times, with a total dose of 15mg/kg. After the last injection was complete...

2024-09-23

[Animal modeling - efficacy evaluation] - transgenic diabetes animal model

Bruning et al. introduced ineffective alleles of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1) into mice through double heterozygosity, resulting in a decrease in IR/IRS-1 expression in the mice...

2024-09-23

[Animal Modeling Drug Efficacy Evaluation] - Spontaneous Animal Tumor Model

A type of tumor that naturally occurs in experimental animal populations without conscious artificial experimental treatment is called spontaneous tumor...

2024-09-23

[Animal modeling - Drug efficacy evaluation] - Myocardial ischemia model induced by vascular stenosis controller

Animal: Pitman Moore strain miniature pig, 7 months old, weighing 40kg; Medications: Ketamine, Atropine, Halothane, O2, CO2; Instruments: Surgical instruments, biological function experimental systems, artificial respirators, ameroid resin vascular s...

2024-09-23

[Animal Modeling Drug Efficacy Evaluation] - Preparation of Furazolidone Mouse Cardiomyopathy Model

Wistar rats were treated with 700 × 10 ^ -6 furazolidone added to drinking water (700mg furazolidone per kilogram of water) and observed for 12 weeks...

2024-09-23

[Animal modeling - efficacy evaluation] - diabetes cataract animal model

Fuhashi et al. selected 36 Charles River rats and injected streptozotocin (100mg/kg) intraperitoneally to make diabetes animal models...

2024-09-23