[Animal Modeling - Efficacy Evaluation] - Rotavirus Infection Animal Model

Rotavirus belongs to the family of enteroviruses and the genus of rotavirus. The virus body is spherical in shape and has a double layered capsid, with each layer of capsid presenting a symmetrical icosahedral shape...

2024-09-25

[Animal Modeling - Pharmacological Evaluation] - Mouse AIDS Model

The replication method randomly selected newborn BALB/c mice and intraperitoneally inoculated them with mouse leukemia virus LP-BM5MuLV suspension at a dose of 0.15ml/mouse, with a virus titer of 3 × 10000PFU/ml...

2024-09-25

[Animal Modeling - Efficacy Evaluation] - Chimpanzee HIV Infection Model

The replication method involves using plasma or virus culture supernatant from AIDS patients (HIV-1), or peripheral blood mononuclear cells (PBMCs) from animals infected with HIV in vitro, or whole blood or free virus from infected animals...

2024-09-25

[Animal Modeling - Pharmacological Evaluation ]- Depression Models in Solitary or Separate Care

Some primates or non primates may exhibit characteristic symptoms such as agitation, sleep disorders, and lamenting after separation from their offspring...

2024-09-25

【Animal Modeling Drug Efficacy Evaluation 】- Transgenic Animal Depression Model

WKY rats are sensitive to various stimuli and exhibit behavioral deficits in several general behavioral tests. In long-term dark environments, their autonomous activity is significantly shortened and their light response is sluggish, similar to that ...

2024-09-25

【Animal Modeling - Efficacy Evaluation】 - Genetic Engineering Animal Model of Catecholamine Substance Action System

Catecholamines include adrenaline, norepinephrine, dopamine, and their metabolites...

2024-09-25

[Animal Modeling - Pharmacological Evaluation] - Primate Parkinson\'s Disease Model

Animals: Healthy rhesus monkeys, male or female, weighing 3.7-5.5kg, aged 4-8 years old; Drug: N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), physiological saline, apomorphine...

2024-09-24

[Animal Modeling Drug Efficacy Evaluation] - Animal Model of Epilepsy Induced by Hymenonic Acid

Healthy male Wistar rats were injected intraperitoneally with physiological saline at doses of 6mg/kg, 10mg/kg, and 14mg/kg, respectively, to establish a good epilepsy model. Generally, 10mg/kg KA intraperitoneal injection has better modeling effect...

2024-09-24

[Animal Modeling - Pharmacological Evaluation] - Partial Simple Epilepsy Model in Rats

rats, male or female, weighing 200-300g; drugs: pentobarbital, FeCl3 solution; Equipment: Rat brain stereotaxic device...

2024-09-24

[Animal Modeling - Pharmacological Evaluation] - Non immune Chronic Renal Failure Rat Model

Male SD rats, 10-12 weeks old, weighing 180-220g; Medications: pentobarbital, benzalkonium bromide...

2024-09-24

Animal Modeling Drug Efficacy Evaluation -5/6 Renal Resection Rat Chronic Renal Failure Model

After trimming the hair at the kidney position on the back of the rat, fix it. Under ether anesthesia, an incision was made at the left dorsal kidney position (in the sham surgery group, only the incision was made and the kidney was not cut). After f...

2024-09-24

[Animal modeling - efficacy evaluation] - primary diabetes BB rats

BB Wistar rat is a spontaneous diabetes animal model...

2024-09-23

[Animal Modeling - Pharmacological Evaluation] - Blood Volume Overload Cardiac Insufficiency Model

The model of heart failure caused by blood volume overload can be divided into acute and chronic types. The acute blood volume overload model is commonly used in animals with already heart failure, usually by rapidly inputting colloidal solution to a...

2024-09-23

[Animal modeling - Drug efficacy evaluation]- Central excitation and inhibition model

Administer 60mg/kg pentylenetetrazol or 200mg/kg nicotine intravenously to animals...

2024-09-23

[Animal modeling - Drug efficacy evaluation] - Animal infection model of Burkholderia mallei

Selecting albino guinea pigs as experimental subjects, the bacterial suspension was intraperitoneally inoculated into guinea pigs at a dilution of 2 × 10000000 CFU/ml...

2024-09-23

[Animal modeling - efficacy evaluation] - Pathological mechanism of conjunctival injury in diabetes model rabbits

By detecting the matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) in conjunctival tissue cells of diabetes rabbits fed with high-fat and high-sugar diet plus streptozotocin, the relationship between them and...

2024-09-23