【Animal modeling】-Protective effect of ulinastatin on acute lung injury in severe heatstroke mice

To investigate the protective effect of ulinastatin on acute lung injury in mice with severe heat stroke...

2024-10-31

【Animal modeling】-Preliminary study on the establishment of quail gout model with high protein and high calcium diet combined with restricted drinking water

By simulating the clinical high-protein and high-calcium diet to induce gout in Difak quail, the method of establishing the gout model of quail was preliminarily discussed, and the basis for the research on the pathogenesis of gout and the screening...

2024-10-31

【Animal Modeling】-TNF-α humanized mouse model of Listeria monocytogenes infection

To evaluate the change of the host\\\\\\\\\\\\\\\'s susceptibility to Listeria monocytogenes infection after TNF-α monoclonal antibody intervention...

2024-10-31

【Animal modeling】-Effect of hypoxia on the expressions of drug transporters MDR1 and MRP2 in rats

To study the effects of simulated rapid altitude hypoxia on some physiological indexes and the expressions of MDR1 and MRP2 efflux drug transporters in the small intestine, liver and kidney of rats, and to preliminarily explore the effect of high alt...

2024-10-31

[Animal modeling] - Prophylactic administration of all trans retinoic acid can alleviate inflammation in rheumatoid arthritis model rats

To explore the effects of all trans retinoic acid (ATRA) on the joint tissue structure, serum expression levels of inflammatory cytokines, and expression levels of cartilage injury related proteins during the formation phase of type II collagen (CIA)...

2024-10-31

【Animal modeling】-Establishment and analysis of a cynomolgus monkey model of hyperlipidemia

To establish a cynomolgus monkey model of hyperlipidemia...

2024-10-30

【Animal modeling】-Effect of ligustrazine on extracellular regulated protein kinase pathway in collagen-induced arthritis rats

To investigate the effect of ligustrazine on extracellular regulated protein kinase pathway in collagen-induced arthritis rats...

2024-10-30

[Animal Modeling] - Thyroidectomy Method for Kidney Yang Deficiency Animal Model

Adult rats were anesthetized, with skin incision, muscle dissection, bilateral thyroid separation and excision, and muscle and skin suturing. Observe the general condition of rats, test left ventricular function and thyroid function, euthanize animal...

2024-10-30

[Animal modeling]-The unique metabolic activation of adipose tissue in obese patients promotes inflammation

Macrophages accumulate in adipose tissue, trigger chronic low-grade inflammation, and promote the development of systemic insulin resistance...

2024-10-30

[Animal Modeling] - Adrenalectomy for Kidney Yang Deficiency Animal Model

Adult rats were anesthetized with ether and bilateral adrenalectomy was performed. After surgery, they were raised in plastic mouse boxes with shavings as bedding, kept at room temperature of 21-25 ℃, and replaced with glucose physiological saline fo...

2024-10-30

[Animal modeling] - Establishment of atherosclerosis animal model by diet induction

The response of different animals to cholesterol is completely different, with rabbits being the most sensitive to cholesterol, while rodents (such as mice and rats) have almost no response to cholesterol. In 1908, Ignatowski, a Russian pathophysiolo...

2024-10-30

【 Animal modeling 】 - The effect of aerobic exercise on the inhibitory synaptic transmission efficiency of dopamine neurons in VTA of nicotine withdrawal mice

To explore the effect of moderate intensity aerobic exercise on inhibitory Synaptic plasticity of VTA dopamine neurons in nicotine withdrawal mice, so as to provide some experimental evidence for reducing nicotine relapse by exercise...

2024-10-30

[Animal Modeling]-A prospective animal study: short-term electrical stimulation and joint exercise after facial nerve injury

Functional impairment caused by facial nerve muscle disease and facial nerve injury is common and serious. Aesthetic defects also bring suffering to patients, leading to social isolation and further emotional distress...

2024-10-29

【Animal Modeling】-Urine Metabonomics Study of Damp-heat Diarrhea Model Rats

Application of UPLC-Q/TOF-MS/MS based on UPLC-Q/TOF-MS/MS urine metabolomics method to screen potential metabolic markers of damp-heat diarrhea and explore damp-heat diarrhea in rats Pathogenesis of diarrhea...

2024-10-29

【Animal Modeling】-Study on Oral Rehydration Salts Reducing Mortality in Rats with Lithium Chloride-Pilocarpine Status Convulsions

To investigate a method for reducing mortality in a lithium chloride-pilocarpine-induced status convulsive model by gastric gavage with modified oral rehydration salts...

2024-10-29

【Animal modeling】-The treatment and mechanism of hemin on gestational hypertensive rats

To preliminarily explore the therapeutic effect and possible regulatory mechanism of heme oxygenase inducer hemin (Hemin) in rats with pregnancy-induced hypertension (HDCP)...

2024-10-23