[Animal Modeling - Efficacy Evaluation] - Copper Sulfate Solution Induced Vomiting Model in Pigeons

Healthy domestic pigeons should be given 300-400g of copper sulfate solution at a dose of 10ml/kg body weight by gavage. After 20 minutes, the pigeons may experience reflexive vomiting...

2024-09-02

【Animal modeling - Drug efficacy evaluation】 - Implantable stone model

Adult dogs, regardless of gender, were anesthetized with 3% pentobarbital sodium intravenously at a dose of 30mg/kg body weight and fixed on the operating table. Routine skin preparation, disinfection, and drape were performed, and a 10cm incision wa...

2024-09-02

[Animal Modeling - Pharmacological Evaluation] - Chemical Induced Cholecystitis Model

Guinea pigs, regardless of gender, weighing 300-400g, were intraperitoneally injected with lincomycin hydrochloride (LIN) at a dose of 60mg/kg body weight once a day for 7 consecutive days; Alternatively, administer lithocholic acid (LCA) at a dose o...

2024-09-02

[Animal Modeling - Pharmacological Evaluation] - Acute Liver Ischemia Induced Liver Failure Animal Model

　　Adult animals, anesthetized and fixed, open the abdomen along the midline, and perform a purse string suture on the inferior vena cava above the renal vein using 5-0 vascular suture thread. After finding the portal vein from the root of the mesente...

2024-09-02

[Animal Modeling - Pharmacological Evaluation] - Liver Resection Induced Liver Failure Animal Model

Adult rats were anesthetized by intraperitoneal injection of ether or ketamine at a dose of 100mg/kg body weight, fixed in a supine position, and opened along a transverse incision in the upper abdomen. The abdominal wall blood vessels were cauterize...

2024-09-02

[Animal modeling - Drug efficacy evaluation] - Induction of liver fibrosis model by common bile duct ligation method

　　Adult rats were anesthetized and their abdominal cavity was opened to locate and free the common bile duct in the mesentery of the descending duodenum. Two silk threads were threaded underneath and a \"V\" - shaped incision was made towar...

2024-09-02

[Animal Modeling - Pharmacological Evaluation] - Carbon Tetrachloride Induced Liver Fibrosis Animal Model

Adult male mice were subcutaneously injected with 20% CCl4 tea oil solution at a dose of 5ml/kg body weight, once every 5 days for 3 consecutive months. Or adult male rats were subcutaneously injected with 3ml/kg body weight of 60% CCl4 peanut oil so...

2024-09-02

[Animal modeling - Drug efficacy evaluation] - Chemical induced fatty liver model

Administer 0.15% carbon tetrachloride (CCk) 10mg/kg body weight to mice at once, or inject D-galactosamine (D-Gal) 800mg/kg body weight intraperitoneally...

2024-09-02

[Animal Modeling - Efficacy Evaluation] - High Fat Feed Induced Fatty Liver Model

Adult rats were fed a high-fat diet containing 2% cholesterol, 10% lard, 0.3% sodium cholate, and other ingredients daily for 8 weeks, or adult rabbits were fed a high-fat diet containing 1% cholesterol and 10% lard at 40g/kg body weight and a high c...

2024-09-02

Animal modeling drug efficacy evaluation - Tsukamoto French model

Implant a gastric tube into the rat during surgery and inject ethanol and other nutrients daily using a liquid pump device. Ethanol accounts for 47% of total calories to maintain an ethanol concentration of 200-300mg/dl (2000-3000mg/L) in animal bloo...

2024-09-02

[Animal Modeling - Efficacy Evaluation] - Lieber Decarli Model

Feed rats with liquid food containing only complete nutrients and alcohol daily. This food is prepared by calories, including 18% protein, 21% fat, 47% sugar (with 36% of calories replaced by alcohol), as well as some vitamins and inorganic salts...

2024-09-02

[Animal modeling - Drug efficacy evaluation] - Alcohol gavage model

Adult male Wistar rats were fed with conventional standard feed, and their drinking water was changed to 10% ethanol beverage. At the same time, they were orally administered 10ml/kg body weight of 50% ethanol twice a day (with a 12 hour interval) fo...

2024-09-02

[Animal modeling drug efficacy evaluation] - Ethanol gavage plus high-fat feeding model

Adult rats were fed a high-fat diet (supplemented with 1% cholesterol and 5% lard on top of a low-fat diet) for one week after normal feeding. At the same time, they were orally administered with 1.5ml/kg body weight of 60% ethanol twice a day for 12...

2024-09-02

【Animal Modeling - Pharmacological Evaluation】 - Rat Acute Renal Failure Model

All animals were weighed before the experiment and deprived of water for 24 hours. Those who lost more than 10% of their body weight entered the experiment and were randomly divided into two groups: the model group [acute renal failure (ARF) group]: ...

2024-09-02

[Animal Modeling Drug Efficacy ]Evaluation Drug Induced Depression Model

Lysine antagonism is the earliest animal model established for antidepressant research after the discovery that monoamine oxidase inhibitors and tricyclic antidepressants can counteract the abnormal behavior caused by Lysine. It is commonly used for ...

2024-08-30

[Animal Modeling - Efficacy Evaluation] - Animal Model of Tinea Infection

Due to their susceptibility to dermatophytosis, guinea pigs often develop spontaneous dermatophytosis, making them an ideal animal model for studying dermatophytosis; In addition, there have also been reports of a rabbit model of dermatophyton...

2024-08-30