
Animal: Male SD rats, weighing 180-250g; Medication: 50% glycerol...
2024-08-30![[Animal Modeling - Pharmacological Evaluation] - High Fat Feed Induced Hyperlipidemia Animal Model in Rabbits](/./uploads/images/default/default.png)
15% egg yolk powder, 0.5% cholesterol, 5% lard, 79.5% basic feed, fed for 6 weeks to form a mold...
2024-08-29![[Animal Modeling - Pharmacological Evaluation] - Rapid Atrial Pacing AF Model](/./uploads/images/default/default.png)
Rapid atrial stimulation has various effects on the electrical activity of atrial cells, such as shortening the effective refractory period (AERP) of the atrium, increasing the heterogeneity (non-uniformity or dispersion) of AERP, and slowing down lo...
2024-08-29
On the 7th and 14th day after removing one kidney, animals were injected twice with 5mg/kg of daunorubicin via tail vein...
2024-08-29
Spinal cord compression is one of the important causes of spinal cord injury. This injury model mainly simulates spinal cord injury caused by space occupying lesions in the spinal canal, which can be divided into acute compression injury and chronic ...
2024-08-28![[Animal Modeling - Pharmacological Evaluation] - Platform Sleep Deprivation Technology](/./uploads/images/default/default.png)
The principle of platform sleep deprivation is to utilize the living habits of rats, which are afraid of water and unable to enter sleep in water. By placing a platform in a water tank, the rats can stand on the platform. Due to the small diameter of...
2024-08-28![[Animal Modeling - Pharmacological Evaluation] - Rat Kidney Disease Model Induced by Elevated Mercury](/./uploads/images/default/default.png)
Intramuscular injection of 12mg/kg mercuric chloride solution into modeling animals...
2024-08-28
Before the experiment, create a ureteral fistula or bladder fistula in the dog, and inject a 2% mercuric solution subcutaneously into the abdomen of the model animal at a dose of 20mg/kg...
2024-08-28![[Animal Modeling Drug Efficacy Evaluation]- Egg Protein Arthritis Model](/./uploads/images/default/default.png)
Dissolve egg protein in physiological saline to prepare a 20g/L solution, and then mix it thoroughly with an equal amount of Freund\'s adjuvant. Subcutaneous injection of animal back, once a week, for 3 consecutive weeks to induce sensitization. Two ...
2024-08-27![[Animal Modeling - Efficacy Evaluation ]- Adjuvant Arthritis Animal Model](/./uploads/images/default/default.png)
Adjuvant arthritis (AA), also known as Freund\'s adjuvant arthritis, was founded by bacteriologist Freund in the 1950s and is the basic method for animal models of immune arthritis...
2024-08-27![[Animal Modeling - Pharmacological Evaluation] - Osteoporosis Animal Model](/./uploads/images/default/default.png)
Female experimental rats were anesthetized by intraperitoneal injection of 2% pentobarbital sodium at a dose of 40mg/kg body weight. A sterile midline incision was made in the lower abdomen, and the abdominal muscles were bluntly separated from the p...
2024-08-27![[Animal Modeling - Pharmacological Evaluation] - Rat Fluoroplaque Animal Model](/./uploads/images/default/default.png)
Select female rats weighing 70-100g after weaning, prepare different concentrations of sodium fluoride solution for poisoning with distilled water, and calculate the poisoning volume based on 0.5ml/100g body weight...
2024-08-27![[Animal modeling - Drug efficacy evaluation] - Establishment of periodontitis model through dietary habits](/./uploads/images/default/default.png)
Adult golden hamsters were fed with Keyes 2000 formula feed (56% fructose, 28% skimmed milk powder, 6% flour, 4% yeast, 3% alfalfa flour, 1% animal liver powder, 2% salt) and a small amount of vegetables. After 6 weeks, microscopic histopathological ...
2024-08-27![[Animal Modeling Drug Efficacy Evaluation] - Recurrent Oral Ulcer Animal Model](/./uploads/images/default/default.png)
Firstly, place the dialysis bag in a 0.5mol/L EDTA solution, boil for 0.5 hours, discard the solution, replace with distilled water and boil again 3 times. Then store it in distilled water containing 0.01% sodium azide and store it at 4 ℃ for future ...
2024-08-27![[Animal Modeling - Pharmacological Evaluation] - Oral Ulcer Animal Model](/./uploads/images/default/default.png)
SD rats weighing 150-180g. Take a 6cm long glass tube with a diameter of 3mm at the lower end, and insert a small cotton ball inside. Make the bottom of the small cotton ball level with the lower opening of the glass tube, and then drip 90% carbolic ...
2024-08-27![[Animal Modeling - Pharmacological Evaluation] - Mercury Raising Induced Kidney Disease Model in Rabbits](/./uploads/images/default/default.png)
male rabbits weighing 2-2.5kg; Drug: mercuric chloride...
2024-08-27