![[Animal Modeling - Pharmacological Evaluation] - Rabbit Oleic Acid Type Acute Lung Injury Model](/./uploads/images/default/default.png)
Healthy rabbits, male or female, weighing 2.0-2.5kg; Medications: Oleic acid, pentobarbital, heparin physiological saline...
2024-08-27![[Animal Modeling - Pharmacological Evaluation] - Pingyangmycin induced Lung Injury Model in Rats](/./uploads/images/default/default.png)
Healthy SD rats, male or female, weighing (210 ± 23) g; Drug: Pingyangmycin, physiological saline; Instrument: Syringe...
2024-08-27![[Animal modeling - Drug efficacy evaluation] - Serum nephritis model](/./uploads/images/default/default.png)
rabbit; Drug: Bovine serum albumin (BSA)...
2024-08-27
rabbits, weighing 2-2.5kg; Drug: Cationized bovine serum albumin (C-BSA)...
2024-08-27![[Animal Modeling - Efficacy Evaluation] - Carbon Tetrachloride Induced Cirrhosis Animal Model](/./uploads/images/default/default.png)
Adult male rats were intraperitoneally injected with 2ml/kg body weight of 30% CCl4 paraffin oil solution twice a week for 7 consecutive weeks...
2024-08-26![[Animal Modeling - Pharmacological Evaluation] - Ethanol Induced Liver Fibrosis Model](/./uploads/images/default/default.png)
Adult rats were given Baijiu (ψ (C2H5OH)=0.56) 7g/kg body weight by gavage once a day in the morning for 24 weeks. Or give Baijiu corn oil pyrazole mixture by gavage once a day in the morning for 12 consecutive weeks...
2024-08-26
Adult rats were anesthetized and their abdominal cavity was opened to locate and free the common bile duct in the mesentery of the descending duodenum. Two silk threads were threaded underneath and a \"V\" - shaped incision was made towards...
2024-08-26
Adult rats were anesthetized by intraperitoneal injection of ether or ketamine at a dose of 100mg/kg body weight, fixed in a supine position, and opened along a transverse incision in the upper abdomen. The abdominal wall blood vessels were cauterize...
2024-08-26![[Animal modeling drug efficacy evaluation] - Ethanol gavage plus high-fat feeding model](/./uploads/images/default/default.png)
Adult rats were fed a high-fat diet (supplemented with 1% cholesterol and 5% lard on top of a low-fat diet) for one week after normal feeding. At the same time, they were orally administered with 1.5ml/kg body weight of 60% ethanol twice a day for 12...
2024-08-26![[Animal modeling - Drug efficacy evaluation] - Intestinal adhesion animal model](/./uploads/images/default/default.png)
Adult rats were fasted and deprived of water for 12-16 hours. After intraperitoneal injection of pentobarbital sodium at a dose of 40mg/kg body weight, the rats were anesthetized and placed supine on a surgical plate. The abdomen was routinely depila...
2024-08-26![[Animal Modeling - Pharmacological Evaluation]- Fetal Mouse Colonic Implantation Induced Ulcerative Colitis Animal Model](/./uploads/images/default/default.png)
Adult SD rats, aged 5-6 months and weighing 250-400g, were implanted with a colon of 3-4cm under the right renal capsule of 14-16-day-old homologous fetal rats. On postoperative days 7, 14, and 21, 5-10ml of cardiac blood was extracted for the separa...
2024-08-26
Adult rats received four immunizations on the 1st, 10th, 17th, and 24th days. The immune substance is a suspension of Escherichia coli cells killed by formaldehyde, with a concentration of 1.2 × 100000000/ml. Preparation method: Take one rat, euthani...
2024-08-26![[Animal Modeling Drug Efficacy Evaluation ]- Duodenal Reflux Surgery Induced Chronic Gastric Ulcer Animal Model](/./uploads/images/default/default.png)
Adult rats were fasted without water for 24 hours, anesthetized with pentobarbital sodium, and placed in a supine position with a midline incision. The lateral wall of the jejunum, 10cm away from the Treitz ligament, was anastomosed with the anterior...
2024-08-26![[Animal modeling drug efficacy evaluation] - HP induced chronic gastric ulcer animal model](/./uploads/images/default/default.png)
BALB/c mice, SPF grade, 5-7 weeks old, fasted for 12 hours, anesthetized and opened the abdomen. At the posterior wall of the greater curvature of the stomach, a No. 2 surgical cotton thread containing corrosive drugs (soaked in a solution of 15% c...
2024-08-26![[Animal Modeling - Pharmacological Evaluation] - Chemical Induced Acute Gastric Ulcer Animal Model](/./uploads/images/default/default.png)
Adult experimental mice were fasted and kept in water for 48 hours. They were orally gavaged with anhydrous ethanol (5ml/kg body weight dose), acetylsalicylic acid (200mg/kg body weight dose), or 0.6mol/L hydrochloric acid (10ml/kg body weight dose)....
2024-08-26![[Animal Modeling - Pharmacological Evaluation] - Gastrointestinal Anastomosis Induced Chronic Atrophic Gastritis Animal Model](/./uploads/images/default/default.png)
Adult rats were fasted without water for 18 hours, and then anesthetized with pentobarbital sodium at a dose of 30mg/kg body weight. The stomach and jejunum were exposed, and the anterior stomach about 2cm away from the pylorus and the jejunum 5-7cm ...
2024-08-26