[Animal Modeling Drug Efficacy Evaluation] - Guinea Pig Pulmonary Tuberculosis Bacterial Model

Female Hartley guinea pigs were used. Mycobacterium tuberculosis in the middle logarithmic growth period was diluted to the required inoculation concentration with sterilized double distilled water. The compartment of the spray was filled with 5ml of...

2024-08-06

【Animal modeling - Drug efficacy evaluation】 - Repeated immunization induced ulcerative colitis in rats

Wistar rats, female, weighing (180 ± 10) g; Medications: pentobarbital, penicillin; Equipment: body locator, electronic stimulator...

2024-08-06

[Animal Modeling Drug Efficacy Evaluation] - Staphylococcus aureus Endometritis Animal Model

Cultivate Staphylococcus aureus ATCC29213 strain and prepare a bacterial suspension of 10000 CFU/ml using physiological saline...

2024-08-06

[Animal modeling - Drug efficacy evaluation]- Establishment of post-traumatic epilepsy animal model by iontophoresis method

Animal: Wistar rats, male, weighing 200-250g; Medication: pentobarbital, FeCl3 solution; Instruments: rat stereotaxic apparatus, wireless Bluetooth EEG monitoring system, high-speed dental drill, tooth holder powder, 1 PVC thin tube with an inner dia...

2024-08-06

[Animal Modeling Drug Efficacy Evaluation] - Rat Pseudomonas aeruginosa Pneumonia Model

Secretory Pseudomonas aeruginosa PAO1 strain and its variant PAOR strain were cultured overnight in tryptone soy broth at 37 ° C. After centrifugation, they were suspended in PBS (pH 7.4), washed by centrifugation, and the precipitate was suspended i...

2024-08-06

[[Animal modeling - efficacy evaluation] - primary diabetes BB rats

BB Wistar rat is a spontaneous diabetes animal model...

2024-08-06

[Animal Modeling - Efficacy Evaluation] - Mongolian Sand Rat Helicobacter pylori Model

5-week-old male Mongolian sand rats without specific pathogen grade were fed standard feed and sterilized water with libitum...

2024-08-06

[Animal Modeling - Pharmacological Evaluation] - Penicillin induced Epilepsy Animal Model

SD rats, half male and half female, weighing (300 ± 20) g; Drug: Penicillin...

2024-08-06

[Animal Modeling Drug Efficacy Evaluation] - Rabbit Pseudomonas aeruginosa Pneumonia Model

Select a small amount of mucinous PA colonies stored at 4 ℃, incubate them in MH broth at 37 ℃ for 24 hours, and prepare a bacterial suspension of 0.5 units using MH broth. Freshly prepare on the same day of use. New Zealand rabbits aged from 18 to 2...

2024-08-06

【Animal modeling - Drug efficacy evaluation】 - Cortical injection of ferrous chloride to establish a traumatic epilepsy animal model

Healthy adult male SD rats weighing 180-220g; Drug: 10% chloral hydrate, FeCl2 solution...

2024-08-06

[Animal Modeling Drug Efficacy Evaluation] - Rhesus Monkey HGV Infection Model

Experimental rhesus monkeys weighing 2.5-6.5kg and aged 2-8 years were selected. Prior to infection, ALT enzyme activity was detected to be normal, and liver biopsy showed no dynamic liver pathological changes...

2024-08-05

[Animal Modeling - Pharmacological Evaluation] - Model of Memory Consolidation Disorder Caused by Electric Shock

Wistar rats, weighing (216 ± 10) g; Instrument: Electroconvulsive device...

2024-08-05

[Animal Modeling - Pharmacological Evaluation] - Model of Memory Consolidation Disorder Caused by Brain Hypoxia

mouse; Drug: a mixture of 96.2% N2 and 3.8% O2 gas, pure CO2, NaNO2; Instrument: a sealed jar...

2024-08-05

[Animal Modeling - Efficacy Evaluation] - Foot and Mouth Disease Virus Animal Model

Dilute the foot-and-mouth disease virus ORMF8 with 0.01mol/L PBS (pH 7.4) to an LD50 of 10-3 to 10-7/0.2ml, and then inject each titer of virus solution intradermally through the hind limb toes of guinea pigs, with an injection dose of 0.2ml per anim...

2024-08-05

【Animal Modeling - Pharmacological Evaluation】 - Tree Shrew Hepatitis B Model

Tree shrews were inoculated via femoral vein with 0.5ml of serum from hepatitis B patients with positive hepatitis B B virus surface antigen (HBsAg) and hepatitis B B virus e antigen (HBeAg)...

2024-08-05

[Animal modeling - Drug efficacy evaluation] - Pulmonary heart disease

Select adult Japanese large eared rabbits and inject a 1% mass fraction of ferric chloride aqueous solution into the rabbit ear vein. Inject 0.5ml twice a week from week 1 to week 4; From the 5th to the 6th week, twice a week, 0.75ml each time; In th...

2024-08-05