![[Animal Modeling - Efficacy Evaluation] - Transgenic Animal Liver Cancer Model](/./uploads/images/default/default.png)
By using genetic engineering methods to introduce specific exogenous genes into the genome of animals, they can undergo integration, genetic reproduction, and thus cultivate animals carrying exogenous genes...
2024-08-02![[Animal Modeling - Pharmacological Evaluation] - Implantable Liver Cancer Animal Model](/./uploads/images/default/default.png)
A liver cancer model formed by transplanting liver cancer tissue, cell lines, or other malignant tumors derived from animals or humans into animal bodies in the future...
2024-08-02![[Animal Modeling - Pharmacological Evaluation] - Induced Liver Cancer Animal Model](/./uploads/images/default/default.png)
Induced liver cancer animal model refers to the use of chemical, physical, and biological carcinogenic factors on experimental animals to simulate the cyclic changes of liver injury fibrosis malignant transformation, and induce the formation of liver...
2024-08-02![[Animal Modeling - Pharmacological Evaluation ]- Ischemic Acute Renal Failure Animal Model](/./uploads/images/default/default.png)
Removing the right kidney and clipping the left renal artery causes ischemic mitochondrial dysfunction in the kidney, resulting in the production of a large amount of hypoxanthine. Under hypoxic conditions, hypoxanthine cannot be metabolized into xan...
2024-08-01![[Animal Modeling - Pharmacological Evaluation] - Rat Chronic Obstructive Pulmonary Disease Model](/./uploads/images/default/default.png)
Chronic obstructive pulmonary disease (COPD) is a chronic respiratory system disease characterized by airflow limitation, with inflammation as the core. It is related to abnormal inflammatory responses of the lungs to harmful gases or particles such ...
2024-08-01![[Animal Modeling - Pharmacological Evaluation] - Norepinephrine Induced Cardiomyopathy Model in Rabbits](/./uploads/images/default/default.png)
Injecting high-dose norepinephrine into rabbits increases myocardial load, causes myocardial degeneration and necrosis, leading to the occurrence of DCM and congestive heart failure...
2024-08-01
rabbits, weighing 2-2.5kg, sheep; Drug: Complete Freund\'s adjuvant...
2024-08-01![[[Animal Modeling - Pharmacological Evaluation] - Animal Model of Qi Deficiency and Blood Stasis Syndrome after Cerebral Infarction (Stroke)](/./uploads/images/default/default.png)
Cerebral infarction belongs to the category of \"stroke\" in traditional Chinese medicine and is a serious disease that threatens human health. Qi deficiency and blood stasis are one of its important pathological mechanisms. The methods for...
2024-08-01
In 1997, Hiroshi Matsuda from the Faculty of Agriculture at Tokyo A&M University in Japan first reported a mouse model of Nc/Nga that spontaneously produced AD phenotype...
2024-08-01![[Animal Modeling - Pharmacological Evaluation] - Choroidal Melanoma Animal Model](/./uploads/images/default/default.png)
The incidence rate of choroidal melanoma in China is second only to retinoblastoma in children, and it is the most common intraocular malignant tumor in adults...
2024-08-01![[Animal Modeling Drug Efficacy Evaluation] - Canine Orthodontic Wire Ligation with Mechanical Injury Periodontitis Animal Model](/./uploads/images/default/default.png)
The clinical characteristics of periodontitis mainly include gingival inflammation, periodontal pocket formation, alveolar bone resorption, and tooth loosening and displacement. Among them, how to prevent further alveolar bone resorption and promote ...
2024-08-01![[Animal Modeling - Pharmacological Evaluation] - Ovarian Resection Induced Osteoporosis Animal Model](/./uploads/images/default/default.png)
Primary osteoporosis includes postmenopausal osteoporosis and senile osteoporosis, mainly characterized by decreased bone mass, degeneration of bone microstructure, decreased bone strength and increased fragility, and susceptibility to fractures. The...
2024-08-01![[Animal Modeling Drug Efficacy ]Evaluation Allergic Conjunctivitis Model](/./uploads/images/default/default.png)
Eye hypersensitivity is mainly a type I hypersensitivity reaction mediated by mast cells. Hericidal conjunctivitis, vernal keratoconjunctivitis, atopic keratoconjunctivitis, and macromastic keratoconjunctivitis are mainly involved in type I allergic ...
2024-08-01![[Animal Modeling - Pharmacological Evaluation] - Low Eye Pressure Glaucoma Disease Animal Model](/./uploads/images/default/default.png)
Low intraocular pressure can cause damage to eye tissue. Long term low intraocular pressure can cause papilledema, retinal hemorrhage, exudation, and radial wrinkles in the macula. The optic disc is a part of the central nervous system, not periphera...
2024-08-01![[Animal Modeling Drug Efficacy]- Evaluation Activated Lymphocytes and Their Chromatin Induced SLE Mouse Model](/./uploads/images/default/default.png)
Using activated lymphocytes from inbred mice as antigens to immunize homologous mice can induce the host to produce self anti dsDNA antibodies, anti nuclear antibodies, etc. Antigen antibody complexes deposit in renal tissue, causing immune complex g...
2024-08-01![[Animal Modeling Drug Efficacy Evaluation]- Induced Hyperthyroidism Animal Model](/./uploads/images/default/default.png)
By orally administering or injecting thyroid hormone, artificially increasing the thyroid hormone content in animals can cause them to exhibit various symptoms of hyperthyroidism...
2024-08-01