[Animal modeling - efficacy evaluation] - Genetic engineering atherosclerosis model

　　6-8 week old ApoE gene deficient mice (strain C57BL/6J), half male and half female, weighing 18-20g, were fed with a \"Western type diet\" feed containing 21% fat and 0.15% cholesterol (treated with 60CO sterilization and irradiation). Th...

2024-08-21

[Animal modeling - efficacy evaluation] - Atherosclerosis model of hypothalamic arcuate nucleus lesion

Newborn Wistar rats were subcutaneously injected with 10% monosodium glutamate at a dose of 4g/kg body weight on the 1st, 3rd, 5th, 7th, and 9th days after birth, for a total of 5 injections...

2024-08-21

[Animal modeling - Drug efficacy evaluation] - Hypertension model induced by medullary nerve compression

After routine anesthesia in adult experimental dogs, tracheal intubation was performed, and a right femoral artery intubation was performed. A multi-channel physiological recorder was connected to monitor blood pressure...

2024-08-21

[Animal modeling - efficacy evaluation] - quail atherosclerosis animal model

Male quail weighing 90-110g and aged 5-6 weeks...

2024-08-21

[Animal modeling - Drug efficacy evaluation] - Extrarenal bandaging induced hypertension model

Also known as extrarenal compression hypertension model, it can be divided into two kidney one bundle type (one kidney bundle, bilateral kidney preservation), one kidney one bundle type (one kidney bundle, contralateral kidney resection), and two kid...

2024-08-21

[Animal Modeling - Pharmacological Evaluation] - Rabbit Hemorrhagic Disease Virus Induced DIC Animal Model

Take HI negative young rabbits weighing 1.5-2.5kg. Each rabbit was intraperitoneally injected with 2ml of 1:10 hepatotoxicity (hemorrhagic virulent FII strain), and their body temperature was measured every 6 hours before and after infection...

2024-08-21

[Animal Modeling - Pharmacological Evaluation] - Escherichia coli endotoxin induced rabbit DIC model

Male New Zealand rabbits weighing around 2kg were injected with 250 μ g of pathogenic Escherichia coli endotoxin through the ear vein...

2024-08-21

【Animal modeling - Drug efficacy evaluation】 - Thrombosis formation in rabbit aorta after intubation injury

The experimental rabbits were fixed after routine anesthesia. Take a polyethylene tube (diameter 0.5-0.7mm) and insert it from the right femoral artery to the aorta. After 4 hours, insert another polyethylene tube into the left carotid artery and was...

2024-08-21

[Animal Modeling - Efficacy Evaluation] - Small Animal Infection Model

The guinea pigs, albino hamsters, black line hamsters, rats, Brandt\'s voles and chickens were infected with 10 5.7 power TCID50/ml SARS-CoV BJ201 strain by nasal drip. The infection doses were 0.5 ml for guinea pigs, 0.2 ml for albino hamsters, 0.2 ...

2024-08-21

[Animal Modeling - Efficacy Evaluation] - SARS Infection Models in Crab eating Monkeys and Rhesus Monkeys

Healthy rhesus macaques and crab eating macaques aged 3-6 years old were anesthetized by intramuscular injection of Rapid Sleep at a dose of 0.15ml/kg body weight, and then infected with SARS CoV BJ01 strain (10 ^ 5.7 TCID50/ml) through nasal and tra...

2024-08-21

[Animal Modeling - Drug Efficacy Evaluation] - Traditional Chinese Medicine Exercise Fatigue Animal Model

The replication method used male Wister rats weighing 180-200g. Mix rhubarb, saltpeter, and standard feed evenly in a ratio of 0.85:0.15:9.0 to make medicinal feed...

2024-08-21

[Animal Modeling - Efficacy Evaluation] - Other Gene Knockout and Transgenic Animal Models

Progressive myoclonic epilepsy (PME) syndrome model, also known as cystatin B gene knockout mouse model...

2024-08-21

[Animal Modeling Drug Efficacy ]-Evaluation Gene Knockout Epilepsy Model

Mainly using gene knockout and transgenic technology for model replication...

2024-08-21

[Animal Modeling Drug Efficacy Evaluation] - Epilepsy like Mouse Primary Epilepsy Model

Measure the degree of seizures in mice before the experiment and select qualified animals for the experiment...

2024-08-21

[Animal Modeling - Drug Efficacy Evaluation] - Mongolian Gerbil Hereditary Epilepsy Model

　　Mongolian sand rats that are sensitive to attacks will be individually housed in separate cages and given free access to food and water. In addition to general hygiene requirements, indoor spaces should be kept quiet, and no noise or movement of ca...

2024-08-21

[Animal Modeling Drug Efficacy Evaluation] - Chronic Experimental Epilepsy Model Induced by Cobalt

Healthy rats weighing 200-300g can be used in females or cats. Anesthetize by intraperitoneal injection of chloral hydrate (dose 350-400 mg/kg body weight) or pentobarbital sodium (dose 50-60 mg/kg body weight)...

2024-08-21