![[Animal Modeling - Pharmacological Evaluation] - Non bacterial Prostatitis Animal Model](/./uploads/images/default/default.png)
Chronic non bacterial prostatitis may be caused by mycoplasma, chlamydia, and autoimmune diseases, which are very similar and non-specific to the clinical symptoms of chronic bacterial prostatitis. The main symptoms include urgency to urinate, pain d...
2024-08-01![[Animal Modeling Drug Efficacy Evaluation] - Human Ovarian Cancer Transplanted Tumor Model in Nude Mice](/./uploads/images/default/default.png)
The nude mouse transplantation model of human ovarian cancer is an ideal carrier for ovarian cancer research, which has important applications in the etiology, pathogenesis, biological characteristics, radioimmunoassay diagnosis, screening of chemoth...
2024-08-01![[Animal Modeling - Efficacy Evaluation] - Transgenic Cervical Cancer Animal Model](/./uploads/images/default/default.png)
Currently, over 200 subtypes of HPV have been identified, of which about 40 subtypes can infect the reproductive tract and be transmitted through sexual contact...
2024-08-01![[Animal Modeling - Pharmacological Evaluation] - Induced Ovarian Cancer Animal Model](/./uploads/images/default/default.png)
Chemical carcinogens are directly applied to tissues through local embedding and other methods. These carcinogens act on the surface epithelium of the ovary, causing cell transformation. At the same time, they may also cause ovarian tumors by damagin...
2024-08-01
The chemical induction method started early and has become the most mature and commonly used method for preparing IBD models since the 1960s. There are many types of chemical irritants, including acetic acid, sodium dextran sulfate, sodium peroxynitr...
2024-08-01
The replication method involves separating the common carotid artery and femoral artery on both sides of the experimental rabbit after routine anesthesia, and clamping the ends of one common carotid artery with two arteries at a distance of about 2.5...
2024-07-31![[Animal modeling - Drug efficacy evaluation ]- Extrarenal bandaging induced hypertension model](/./uploads/images/default/default.png)
Also known as extrarenal compression hypertension model, it can be divided into two kidney one bundle type (one kidney bundle, bilateral kidney preservation), one kidney one bundle type (one kidney bundle, contralateral kidney resection), and two kid...
2024-07-31![[Animal Modeling Drug Efficacy Evaluation] - Preparation of Canine Chronic Myocardial Ischemia and Infarction Model with Chest Closure](/./uploads/images/default/default.png)
The replication method was performed on experimental dogs weighing 10-15kg. After routine anesthesia, Seldinger technique was used to deliver self-made polyvinyl chloride constrictors (including effective stenosis length of 10mm) through the right fe...
2024-07-31![[Animal modeling - Drug efficacy evaluation] - Microsphere injection induces myocardial ischemia](/./uploads/images/default/default.png)
Take experimental dogs weighing about 30kg and administer intravenous injection of phenobarbital sodium at a dose of 35-40mg/kg body weight for anesthesia, while maintaining anesthesia at 4mg/(kg · h). Animal\'s right lateral position fixed, tracheal...
2024-07-31![[Animal modeling - Drug efficacy evaluation] - Drug induced myocardial ischemia](/./uploads/images/default/default.png)
Rats weighing around 200g (excluding animals with abnormal electrocardiograms) were subjected to myocardial ischemia induced by posterior pituitary hormone. The rats were injected with posterior pituitary hormone via sublingual or tail vein at a dose...
2024-07-31![[Animal Modeling - Pharmacological Evaluation] - Animal Model of Psychological Stress and Liver Depression Syndrome](/./uploads/images/default/default.png)
Psychological stress is the process in which the body perceives the threat of stressors through recognition and evaluation when stimulated by various internal and external environmental factors, leading to changes in psychological and physiological f...
2024-07-31![[Animal modeling - Drug efficacy evaluation] - Rat pulmonary edema model replication](/./uploads/images/default/default.png)
Toxic doses of adrenaline and iron amide can cause tachycardia, and the left ventricle cannot fully discharge the injected blood. The end diastolic pressure of the left ventricle gradually increases, which can cause an increase in pressure in the rig...
2024-07-31![[Animal modeling - Drug efficacy evaluation] - Inducing spontaneous osteoarthritis formation model](/./uploads/images/default/default.png)
Approximately 38% to 65% of OA patients have a genetic background in their etiology, suggesting that the cause of OA in these patients may be related to certain genetic mutations in themselves...
2024-07-31![[Animal Modeling - Pharmacological Evaluation] - defocus induced myopia animal model](/./uploads/images/default/default.png)
The modeling mechanism uses various methods to focus the object image behind the retina, causing the eyeball to be in a farsighted optical defocus state...
2024-07-31![[Animal Modeling - Pharmacological Evaluation] - Transplanted Nasopharyngeal Carcinoma Animal Model](/./uploads/images/default/default.png)
Transplanted nasopharyngeal carcinoma animal model refers to a model cultivated by transplanting human nasopharyngeal carcinoma tissue or cells into experimental animals. It is one of the most commonly used animal models for nasopharyngeal carcinoma ...
2024-07-31![[Animal Modeling - Pharmacological Evaluation] - Nasopharyngeal Carcinoma Metastasis Animal Model](/./uploads/images/default/default.png)
Establishing an animal model of nasopharyngeal carcinoma metastasis is one of the important approaches for nasopharyngeal carcinoma research, as it is prone to lymph node, liver, lung, and bone metastasis...
2024-07-31