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【Animal Modeling】-Comparison of morphological characteristics of liver tissue between four commonly used experimental animals and humans

【Animal Modeling】-Comparison of morphological characteristics of liver tissue between four commonly used experimental animals and humans

To provide reference for the selection of experimental animals in liver research by comparing the histomorphological similarity between the livers of four commonly used experimental animals, mice, rats, guinea pigs, and rabbits, and human livers...

2024-06-26
【Animal modeling】-The role and mechanism of miR-221 in H2O2-induced myocardial cell injury in rats

【Animal modeling】-The role and mechanism of miR-221 in H2O2-induced myocardial cell injury in rats

To investigate the role and mechanism of miR-221 in hydrogen peroxide (H2O2)-induced rat cardiomyocyte (H9c2) injury...

2024-06-26
【Animal Modeling】-Establishment of a Rat Model of Ovarian Hyperstimulation Syndrome

【Animal Modeling】-Establishment of a Rat Model of Ovarian Hyperstimulation Syndrome

To screen and compare the establishment of a rat model of ovarian hyperstimulation syndrome (OHSS), and to provide a good animal model for the study of the mechanism of OHSS and the development of therapeutic drugs...

2024-06-26
【Animal modeling】-Effect of Roux-en-Y gastric bypass on liver and peripheral insulin sensitivity in type 2 diabetic rats

【Animal modeling】-Effect of Roux-en-Y gastric bypass on liver and peripheral insulin sensitivity in type 2 diabetic rats

To observe the changes of insulin sensitivity in the liver and peripheral tissues of type 2 diabetic rats at different times after RYGB and to preliminarily explore the possible mechanism...

2024-06-26
【Animal modeling】-Effect of natural enemy sound stress on anxiety-like behavior in SD rats

【Animal modeling】-Effect of natural enemy sound stress on anxiety-like behavior in SD rats

To observe the effects of natural enemy sounds on anxiety-like behaviors of SD rats under different durations and repeated stress...

2024-06-26
[Animal modeling] - Study on the safety and effectiveness of human umbilical cord mesenchymal stem cells in the treatment of acute lung injury in mice

[Animal modeling] - Study on the safety and effectiveness of human umbilical cord mesenchymal stem cells in the treatment of acute lung injury in mice

To investigate the safety and efficacy of human umbilical cord mesenchymal stem cells (HUC MSCs) in the treatment of lipopolysaccharide (LPS) - induced acute lung injury in mice...

2024-06-26
【Animal Modeling】-Hydrogen-rich liquid attenuates cerebral ischemia-reperfusion injury in rats through PI3K pathway

【Animal Modeling】-Hydrogen-rich liquid attenuates cerebral ischemia-reperfusion injury in rats through PI3K pathway

To investigate the effect of hydrogen-rich solution on the apoptosis of hippocampal neurons and the expression of PI3K/Akt/FoxO1 signaling pathway induced by cerebral ischemia-reperfusion in rats...

2024-06-24
[Animal modeling] - The role of villin 1 in the model of unilateral nephrectomy Habu nephritis in mice

[Animal modeling] - The role of villin 1 in the model of unilateral nephrectomy Habu nephritis in mice

To investigate the similarities and differences between unilateral nephrectomy (UNX) mouse Habu nephritis model and normal mouse Habu nephritis model in renal function, renal pathology and expression of glomerular villin 1 (VIL 1) and their molecular...

2024-06-24
[Animal Modeling - Pharmacodynamic Evaluation] - Spontaneous Vitiligo Animal Model

[Animal Modeling - Pharmacodynamic Evaluation] - Spontaneous Vitiligo Animal Model

Humans can induce local depigmentation in some animals, such as chickens, rodents, dogs, cats, and horses. These animals often have anti melanocyte antibodies in their bodies, with the most commonly used being Smyth line (SL) chickens and C57BL mice...

2024-06-19
【Animal modeling 】- Pharmacodynamic evaluation - Homologous/xenograft squamous cell carcinoma model

【Animal modeling 】- Pharmacodynamic evaluation - Homologous/xenograft squamous cell carcinoma model

Inoculating human SCC tissue or cancer cells into the back, forelimb armpits, inguinal area, lateral chest wall, or sublingual area of immunodeficient mice can produce SCC locally...

2024-06-19
[Animal modeling - Pharmacodynamic evaluation] - Gene modified squamous cell carcinoma model

[Animal modeling - Pharmacodynamic evaluation] - Gene modified squamous cell carcinoma model

Numerous genes are involved in the pathogenesis of SCC, and gene modified animal models with high or no expression of specific genes can spontaneously or externally induce SCC...

2024-06-19
Animal Modeling Pharmacodynamic Evaluation Radiation induced Cataract Animal Model

Animal Modeling Pharmacodynamic Evaluation Radiation induced Cataract Animal Model

Ultraviolet (UV) in nature is divided into UVA (315-400nm), UVB (280-315nm), and UVC (100-280nm). The atmospheric ozone can absorb UV with a wavelength less than 280nm, and what enters the ground are UVB and UVA. The most sensitive UV wavelength of t...

2024-06-19
[Animal modeling - Pharmacodynamic evaluation] - Preparation of chronic myeloid leukemia animal model using virus transfection method

[Animal modeling - Pharmacodynamic evaluation] - Preparation of chronic myeloid leukemia animal model using virus transfection method

Chronic myeloid leukemia (CML) is a type of malignant tumor that involves bone marrow hematopoietic stem cells. Ph chromosome or bcr/Abl positivity is a molecular genetic characteristic of CML patients. Therefore, using a reverse transcription virus ...

2024-06-19
[Animal modeling - Pharmacodynamic evaluation ]- Wild lily alkaloid induced pulmonary heart disease model in rats

[Animal modeling - Pharmacodynamic evaluation ]- Wild lily alkaloid induced pulmonary heart disease model in rats

The animals in the 60mg/kg modeling group were injected subcutaneously under the scapula, or injected intraperitoneally with a 60mg/kg solution of wild lily alkaloids...

2024-06-19
【Animal modeling - pharmacological evaluation】 -1. Iron trichloride induced pulmonary heart disease model

【Animal modeling - pharmacological evaluation】 -1. Iron trichloride induced pulmonary heart disease model

The animals in the modeling group were injected with 3% ferric chloride solution via the rabbit ear vein, starting at 0.5ml each time, three times a week, and gradually increasing to four times, with a total injection of 45-60ml. During the injection...

2024-06-19
【Animal Modeling】-Effect of Bushen Bujing Recipe on Tripterygium wilfordii polyglycosides-induced premature ovarian failure rat model

【Animal Modeling】-Effect of Bushen Bujing Recipe on Tripterygium wilfordii polyglycosides-induced premature ovarian failure rat model

Primary hypogonadism is defined as ovarian insufficiency with high serum follicle-stimulating hormone (FSH) levels. In women, one of the most common forms of primary hypogonadism is premature ovarian failure (POF), also known as premature menopause...

2024-06-18