[Animal modeling] - Establishment of a tracer model of sodium hyaluronate distribution in rabbit knee joint cavity

To establish a tracking model of sodium hyaluronate (HA) distribution in rabbit knee joint cavity by dual source CT scanning and X-ray fluoroscopy, and to observe the influence of different administration sites on the distribution of HA in rabbit kne...

2024-06-12

【Animal modeling】-Isoproterenol-induced myocardial hypertrophy model rats based on implantable osmotic pump to improve and evaluate the conditions

Cardiac hypertrophy is a slowly developing and effective compensatory function, an adaptive response to hemodynamic or myocardial injury, and an independent risk factor for heart failure...

2024-06-12

[Animal modeling] - A new method to improve the success rate of rat endometriosis modeling

To provide an ideal animal model for the study of new therapeutic methods of endometriosis...

2024-06-12

Animal modeling drug efficacy evaluation X-ray induced pulmonary fibrosis model

The modeling animals were subjected to half chest or full body irradiation, and the mice received 11 Gy full body irradiation for 28 days; Rats received 30 Gy of half chest irradiation for 3 months...

2024-06-11

[Animal modeling] - Effect of membrane cells on granulosa cells injured by chemotherapy and intervention of Zuogui Pill containing serum

To investigate the effect of membrane cells on granulosa cells injured by chemotherapy and the intervention of Zuogui Pill containing serum...

2024-06-07

[Animal modeling] - oleic acid induced pulmonary edema model in rabbits

　　Intravenous anesthesia with ethyl carbamate (1g/kg), followed by systemic heparinization after tracheal intubation. Insert a catheter into the right common carotid artery for blood sampling. Control group: Intravenous injection of physiological sal...

2024-06-04

【Animal modeling】 - adrenaline induced pulmonary edema model in rabbits

Rabbits were anesthetized by intravenous injection of 25% Ulartan 100mg/kg into the ear margin and fixed on the operating table. Cut off the hair on the neck, separate the trachea, and perform tracheal intubation. Inject 0.4-0.6mg/kg of 1:5000 adrena...

2024-06-04

【Animal Modeling】-Acupuncture improves symptoms of insomnia rats and effects on spontaneous activity by regulating GABA-Gln metabolism

To study the improvement of symptoms of acupuncture on insomnia rats and its effect on spontaneous activity, and to explore its possible mechanism...

2024-06-04

[Animal modeling] - Leptin receptor knockout causes microglia activation in rat brain tissue

To study the morphological and functional changes of microglia in rat brain after leptin receptor (LEPR) gene knockout, and explore the function of leptin receptor in microglia...

2024-06-04

[Animal modeling] - Experimental pulmonary edema model induced by nitrogen tetroxide in rats

Animals in the modeling group were induced to inhale N2O4 [concentration of (352 ± 21) mg/m3] for 0.5 hours to replicate an acute pulmonary edema model. The method is to take 25 μ l of liquid N2O4 for the first time, inject it into a 120L toxicity ca...

2024-06-03

[Animal modeling] - Acute pulmonary edema in rats

Model group animals were anesthetized intraperitoneally with pentobarbital 30mg/kg body weight, femoral artery was separated, intubation was performed, and blood pressure was measured; Separate the jugular vein, intubate, monitor with an oscilloscope...

2024-06-03

[Animal modeling] - Experimental model of recurrent pulmonary edema

Animal: Healthy rabbit, weighing 2.5-3.5kg, both male and female; Medication: pentobarbital; Equipment: 12F chest tube equipped with a valve (modified from a 12F catheter with a valve installed at the end of the urine bag), 60ml syringe...

2024-06-03

[Animal modeling] - Physiological saline induced pulmonary edema animal model

After anesthesia, the animal in the modeling group is cut open in the neck, separated from the skin, and intubated with the trachea, one artery, and the other vein. Normal breathing, blood pressure, and lung breathing sounds are recorded. A large amo...

2024-06-03

【Animal modeling】 - Ammonium chloride induced pulmonary edema animal model

Animals in the modeling group were intraperitoneally injected with 0.6ml/100g of ammonium chloride (rat, drug concentration 6%), 0.15ml/10g of body weight (mouse, drug concentration 3%), and 0.5-0.7ml/kg (guinea pig, drug concentration 6%)...

2024-06-03

[Animal modeling] - Establishment of a mouse model of adverse skin reactions induced by erlotinib

Elotinib is a new targeted drug for the treatment of non-small cell lung cancer. In recent years, it has been widely used in clinical practice, but there are many side effects, among which rash is the most common, and it is most difficult for patient...

2024-06-03

【Animal modeling】-Effect of metformin on cognitive dysfunction and PI3K/Akt pathway in Alzheimer\\\\\\\\\\\\\\\\

To investigate the effect of metformin on phosphatidylinositol-3-kinase/protein kinase B pathway and cognitive dysfunction in Alzheimer\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\'s disease rats...

2024-06-03