【Animal Modeling】-A Modified Rat Jugular Vein Intubation for Autonomous Drug Administration and Its Application

To introduce an improved rat jugular vein cannula fabrication method and jugular vein cannulation operation method, and apply it to an experimental study of autonomous drug administration in rats to evaluate the service life and application effect of...

2024-02-17

【Animal modeling】- Oral human alpha interferon transforms Bifidobacterium to promote the proliferation and maturation of mouse lymphocytes

To investigate the regulatory effect of human alpha interferon (IFN-α) gene on the immune function of mice after oral administration of Bifidobacterium transformed...

2024-02-17

【Animal Modeling】-Comparison of intravenous injection needle and self-made PE-50 needle in the measurement of intracavernous pressure in rats

To investigate the method of electrical stimulation of the cavernosal nerve of the penis to detect the intracavernous pressure, and to compare the differences between the two materials (PE-50 tube needle and intravenous infusion needle) for detecting...

2024-02-17

[Animal modeling] - Study on the effect and mechanism of Bushen Yiqi Huayu Granule on angiogenesis in ovariectomized osteoporosis model rats

Purpose based on TLRs/NF- κ B signal pathway was used to explore the effect of Bushen Yiqi Huayu Granule on angiogenesis in osteoporosis rats...

2024-02-06

[Animal modeling] - Transcriptome analysis of colon tissue in IBD mice under the intervention of mesalazine

To detect the changes of gene expression in colon tissue of mice with inflammatory bowel disease (IBD) by transcriptome sequencing, and to improve the understanding of the molecular mechanism of mesalazine in the treatment of IBD...

2024-02-06

[Animal modeling] - Ebola virus non human primate model

Many non-human primates have been used in the study of Ebola animal models, including African green monkeys, baboons, rhesus monkeys, and crab eating monkeys. Rhesus monkeys and crab eating monkeys are currently the most widely used, both highly sens...

2024-02-06

【Animal Modeling】-Effects of repeated hypoxic preconditioning on liver injury caused by renal ischemia-reperfusion in rats

To explore the effects of repeated hypoxic preconditioning (RHP) on liver injury caused by renal ischemia-reperfusion injury (IRI) in rats and to preliminarily explore its mechanism...

2024-01-30

【Animal Modeling】-Effect of fasting time on glucose tolerance and insulin secretion in Kunming mice

In order to explore the stable, reliable and reasonable fasting time of OGTT in Kunming mice, which are used the most in China in a specific environment...

2024-01-30

[Animal modeling]-Occupational asthma model induced by methyl toluene diisocyanate

Formaldehyde diisocyanate (TDI) is a low-molecular chemical substance with only hapten properties in the human body. TDI has obvious obvious mucosal irritation and corrosion. Exposing animals to 1.5 ppm TDI for one or several months can cause animal...

2024-01-30

【Animal modeling】-Optimization of the establishment of rat interstitial cystitis model induced by intraperitoneal injection of cyclophosphamide

To explore the ideal dose of intraperitoneal injection of cyclophosphamide to establish a rat model of interstitial cystitis...

2024-01-30

【Animal Modeling】-Analysis of the Rationality of Rabbit KOA Staging Model by Braking Method

To establish different stages of knee osteoarthritis model with plaster immobilization, in order to provide an appropriate animal model for precise treatment of acupuncture and traditional Chinese medicine...

2024-01-30

【Animal Modeling】-Comparison of the genetic structure of two experimental mouse populations using microsatellite technology

To compare the genetic structure of two experimental mouse populations using microsatellite markers...

2024-01-30

【Animal modeling】-Preliminary study on establishment of rat model of granulomatous lobular mastitis

To establish an animal model of granulomatous lobular mastitis by using the homogenate of human granulomatous lobular mastitis and the suspension of complete Freund\\\'s adjuvant...

2024-01-30

[Animal modeling] - Pancreatic kallidinogenase alleviates oxidative stress and fibrosis in rats with myocardial ischemia-reperfusion injury

To investigate the effects of pancreatic kallidinogenase on myocardial injury, oxidative stress and fibrosis in rats with myocardial ischemia reperfusion injury...

2024-01-30

【Animal Modeling】-Model of gastric ulcer caused by pyloric ligation

After the pylorus is ligated, the gastric juice remains in the stomach, and the effects of gastric acid and pepsin are enhanced. The stomach enlarges the antrum due to the pylorus ligation, and the reflex stimulates the secretion of gastrin, leading...

2024-01-30

【Animal modeling】-The phenotypic characteristics of lymphocytes in HBV transgenic mice and the effect of interferon α on them

To investigate the phenotypic characteristics of lymphocytes in hepatitis B virus (HBV) transgenic mice and the effect of interferon α on virological indexes and immune cell phenotypes...

2024-01-30