【Animal Modeling】-Analysis of the effects of different hypoxia exposure modes on differential gene expression of rat tibialis anterior muscle based on RNA sequencing

To screen the differentially expressed genes and their related pathways in rat tibialis anterior muscle from chronic intermittent hypoxia exposure and acute hypoxia exposure...

2024-01-16

【Animal Modeling】-Exploring the neuroprotective effect of DAHP on brain trauma rats based on NOS pathway

To investigate the neuroprotective effect of 2,4-diamine-6-hydroxypyrimidine (DAHP) on traumatic brain injury rats, and to explore its possible mechanism...

2024-01-16

【Animal Modeling】-Application of intracavitary shunt plug in rat abdominal cavity heterotopic heart transplantation

To investigate the application of intravascular shunt thrombus in establishing a rat model of heterotopic heart transplantation in the abdominal cavity...

2024-01-15

[Animal Modeling]-Long-term survival rat model of moderate to severe sepsis

Establish a long-term survival rat model of moderate to severe sepsis, observe the natural development of sepsis, and provide new ideas and methods for the study of sepsis...

2024-01-15

【Animal Modeling】-Hemophilia Gene Therapy Animal Trials Successfully

Hemophilia is a disease caused by hereditary coagulation dysfunction, which is characterized by the inability of the body to produce coagulation factors or insufficient production of coagulation factors, resulting in prolonged coagulation time and di...

2024-01-15

【Animal Modeling】-Comparative Study on Visceral Hypersensitivity Models Induced by Combined Method

To observe the effect of maternal-infant separation combined with mechanical stimulation and drug combined with chronic stress on the visceral hypersensitivity model of irritable bowel syndrome, and to explore the advantages and disadvantages of the...

2024-01-15

【Animal modeling】-Cloning of IFITM3 gene in African green monkey and its tissue-specific expression differences

To study the function of interferon-induced transmembrane protein 3 in African green monkeys, as well as the mechanism and mode of its antiviral effect, the IFITM3 gene was cloned from different tissues and organs of African green monkeys, and the ex...

2024-01-15

【Animal Modeling】-Preparation of a mouse model of diarrhea-type irritable bowel syndrome induced by acetic acid combined with restraint stress

To establish a mouse model of diarrhea-predominant irritable bowel syndrome by rectal infusion of 3% acetic acid (AA) combined with restraint stress, and to evaluate the feasibility of the model...

2024-01-15

【Animal Modeling】-Expression of BDNF, trkB and ChAT mRNA and protein in the brain of adult Chinese shrew

To observe the mRNA and protein expressions of BDNF, trkB and ChAT in the brains of adult Chinese shrew...

2024-01-15

【Animal modeling】-Polymorphism analysis of PPARγ2 gene promoter in Wuzhishan miniature pigs

To analyze the polymorphisms in the regulatory region of the PPARγ2 gene promoter in Wuzhishan miniature pigs...

2024-01-13

To investigate the effect of atorvastatin on myelin repair and RhoA/Rock1 pathway in autoimmune encephalomyelitis (EAE) mice

To investigate the effect of atorvastatin on myelin repair and RhoA/Rock1 pathway in autoimmune encephalomyelitis (EAE) mice...

2024-01-13

[Animal modeling] - Observation on the effect of Lumianning Ⅱ and ketamine combined with propofol on the experimental pigs undergoing endoscopic surgery via natural cavity

To observe the anesthetic effect of induced anesthetics Lumianning Ⅱ or ketamine combined with propofol on experimental pigs undergoing the placement of gastric gallbladder stent for bile conservation and lithotomy through the natural lumen endoscopi...

2024-01-12

【Animal modeling】-Effect of curcumin on Keap1/ARE signaling pathway and bile acid enterohepatic circulation in liver cancer model mice

To investigate the effect of curcumin on cytoplasmic protein chaperone (Keap1)/antioxidant response element (ARE) signaling pathway and bile acid enterohepatic circulation in liver cancer model mice...

2024-01-12

[Animal modeling] - The neuroprotective effect of tanshinone IIA on Alzheimer\'s disease model mice and its impact on the PI3K/AKT pathway

To investigate the neuroprotective effect of tanshinone IIA (Tan IIA) on Alzheimer\\\\\\\'s disease (AD) model mice and its effect on phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) pathway...

2024-01-12

【Animal modeling】-Bakuchiol for the treatment of castration-induced osteoporosis in male mice

To observe the therapeutic effect of bakuchiol on castration-induced osteoporosis in male mice...

2024-01-12

【Animal Model】-Interventional effect of valsartan on the activity of rat glomerular mesangial cells induced by high glucose

To investigate the effect and mechanism of valsartan on the proliferation and apoptosis of rat renal cells induced by high glucose...

2024-01-12