【Animal modeling - Drug efficacy evaluation】 - Cryotherapy combined with resection method induced chronic renal failure rat model

Anesthetize animals with 30mg/kg pentobarbital, disinfect the skin routinely, make an incision on the left side of the abdomen, expose the left side, and peel off the renal fascia. Freeze the upper, lower, lateral anterior, and posterior parts of the...

2024-09-27

[Animal Modeling - Efficacy Evaluation] - Transgenic Mouse Infection Model

Cut the fragment containing HCV 5\'UTR and structural genes (C1+E1+E2) from the pHCS plasmid by enzymatic digestion, pass it through the intermediate vector pMT, and then perform enzymatic digestion to construct a new plasmid (pCBE). After amplificat...

2024-09-26

[Animal Modeling - Pharmacological Evaluation] - Chronic Renal Failure Rat Model Induced by Xiaozhiling

Model animals are first anesthetized with ketamine and diazepam, supplemented with ether inhalation if necessary. Rats were fixed in a supine position, and a 1.2ml dilution of refined Xiaozhiling injection was prepared by adding an equal amount of ph...

2024-09-26

【Animal Modeling - Pharmacological Evaluation】 - Adenosine induced Chronic Renal Failure Rat Model

1ml of adenine suspension was prepared at a daily dose of 200mg/kg and administered to rats by gavage at regular intervals, with a total cumulative dose of 1.5g/animal. The entire modeling process lasted for 24 days. Administer once a day from day 1 ...

2024-09-26

[Animal modeling - Drug efficacy evaluation] - Negative pressure traumatic brain injury model

The negative pressure traumatic brain injury model established by Mahmood et al. mainly consists of a stent, straw, syringe tube, spring coil, pressure sensing transducer, oscilloscope, etc...

2024-09-25

[Animal Modeling - Efficacy Evaluation] - Hepatitis B Virus Infection Model

Hepatitis B virus belongs to the hepatotropic DNA virus, which is a complex DNA virus. Since the 1970s, researchers have identified Dane particles (i.e. HBV particles) under electron microscopy and clarified that the surface component of HBV particle...

2024-09-25

[Animal Modeling - Efficacy Evaluation] - Rotavirus Infection Animal Model

Rotavirus belongs to the family of enteroviruses and the genus of rotavirus. The virus body is spherical in shape and has a double layered capsid, with each layer of capsid presenting a symmetrical icosahedral shape...

2024-09-25

[Animal Modeling - Pharmacological Evaluation] - Mouse AIDS Model

The replication method randomly selected newborn BALB/c mice and intraperitoneally inoculated them with mouse leukemia virus LP-BM5MuLV suspension at a dose of 0.15ml/mouse, with a virus titer of 3 × 10000PFU/ml...

2024-09-25

[Animal Modeling - Efficacy Evaluation] - Chimpanzee HIV Infection Model

The replication method involves using plasma or virus culture supernatant from AIDS patients (HIV-1), or peripheral blood mononuclear cells (PBMCs) from animals infected with HIV in vitro, or whole blood or free virus from infected animals...

2024-09-25

[Animal Modeling - Pharmacological Evaluation ]- Depression Models in Solitary or Separate Care

Some primates or non primates may exhibit characteristic symptoms such as agitation, sleep disorders, and lamenting after separation from their offspring...

2024-09-25

【Animal Modeling Drug Efficacy Evaluation 】- Transgenic Animal Depression Model

WKY rats are sensitive to various stimuli and exhibit behavioral deficits in several general behavioral tests. In long-term dark environments, their autonomous activity is significantly shortened and their light response is sluggish, similar to that ...

2024-09-25

【Animal Modeling - Efficacy Evaluation】 - Genetic Engineering Animal Model of Catecholamine Substance Action System

Catecholamines include adrenaline, norepinephrine, dopamine, and their metabolites...

2024-09-25

[Animal Modeling - Pharmacological Evaluation] - Primate Parkinson\'s Disease Model

Animals: Healthy rhesus monkeys, male or female, weighing 3.7-5.5kg, aged 4-8 years old; Drug: N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), physiological saline, apomorphine...

2024-09-24

[Animal Modeling Drug Efficacy Evaluation] - Animal Model of Epilepsy Induced by Hymenonic Acid

Healthy male Wistar rats were injected intraperitoneally with physiological saline at doses of 6mg/kg, 10mg/kg, and 14mg/kg, respectively, to establish a good epilepsy model. Generally, 10mg/kg KA intraperitoneal injection has better modeling effect...

2024-09-24

[Animal Modeling - Pharmacological Evaluation] - Partial Simple Epilepsy Model in Rats

rats, male or female, weighing 200-300g; drugs: pentobarbital, FeCl3 solution; Equipment: Rat brain stereotaxic device...

2024-09-24

[Animal Modeling - Pharmacological Evaluation] - Non immune Chronic Renal Failure Rat Model

Male SD rats, 10-12 weeks old, weighing 180-220g; Medications: pentobarbital, benzalkonium bromide...

2024-09-24