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【Animal Modeling】-CBA/CaJ Mice Organ Weight, Blood Physiological and Biochemical Indexes and Immune Cell Proportion

【Animal Modeling】-CBA/CaJ Mice Organ Weight, Blood Physiological and Biochemical Indexes and Immune Cell Proportion

To determine the basic biological indicators of SPF CBA/CaJ mice, and to lay a foundation for better use of this strain of mice for biomedical research...

2024-06-27
【Animal Modeling - Pharmacodynamic Evaluation】- Guinea Pig Tuberculosis Model

【Animal Modeling - Pharmacodynamic Evaluation】- Guinea Pig Tuberculosis Model

Subcutaneous injection of 0.1mg of bacteria into the armpit or chest of the modeling animal...

2024-06-27
[Animal Modeling Pharmacodynamic Evaluation] - Mouse Tuberculosis Model

[Animal Modeling Pharmacodynamic Evaluation] - Mouse Tuberculosis Model

Animal models were made by injecting physiological saline into the tail vein, containing 1-5mg/ml of highly toxic human tuberculosis bacteria (H37RV), 0.2ml per animal...

2024-06-27
[Animal modeling - Pharmacodynamic evaluation] - Dynamic lung injury model in chronic pressure overload rats

[Animal modeling - Pharmacodynamic evaluation] - Dynamic lung injury model in chronic pressure overload rats

sham surgery group: Except for not using silk thread to ligate the abdominal aorta, all other steps were the same as the surgery group; Operation group: the model of pressure overload myocardial hypertrophy was prepared according to the abdominal aor...

2024-06-27
【Animal modeling - Pharmacodynamic evaluation】 - Surgical induced pulmonary heart disease model

【Animal modeling - Pharmacodynamic evaluation】 - Surgical induced pulmonary heart disease model

  The dog underwent thoracotomy under general anesthesia, and the descending aorta was anastomosed with the left pulmonary artery, with a anastomotic opening of less than 1cm. The use of aortic pressure resulted in simple pulmonary hypertension. Alte...

2024-06-27
【Animal modeling】-Study on the synergistic and detoxification effect of pine pollen on cyclophosphamide

【Animal modeling】-Study on the synergistic and detoxification effect of pine pollen on cyclophosphamide

To study whether pine pollen has synergistic and attenuating effects on cyclophosphamide chemotherapy...

2024-06-26
【Animal Modeling】-Comparison of morphological characteristics of liver tissue between four commonly used experimental animals and humans

【Animal Modeling】-Comparison of morphological characteristics of liver tissue between four commonly used experimental animals and humans

To provide reference for the selection of experimental animals in liver research by comparing the histomorphological similarity between the livers of four commonly used experimental animals, mice, rats, guinea pigs, and rabbits, and human livers...

2024-06-26
【Animal modeling】-The role and mechanism of miR-221 in H2O2-induced myocardial cell injury in rats

【Animal modeling】-The role and mechanism of miR-221 in H2O2-induced myocardial cell injury in rats

To investigate the role and mechanism of miR-221 in hydrogen peroxide (H2O2)-induced rat cardiomyocyte (H9c2) injury...

2024-06-26
【Animal Modeling】-Establishment of a Rat Model of Ovarian Hyperstimulation Syndrome

【Animal Modeling】-Establishment of a Rat Model of Ovarian Hyperstimulation Syndrome

To screen and compare the establishment of a rat model of ovarian hyperstimulation syndrome (OHSS), and to provide a good animal model for the study of the mechanism of OHSS and the development of therapeutic drugs...

2024-06-26
【Animal modeling】-Effect of Roux-en-Y gastric bypass on liver and peripheral insulin sensitivity in type 2 diabetic rats

【Animal modeling】-Effect of Roux-en-Y gastric bypass on liver and peripheral insulin sensitivity in type 2 diabetic rats

To observe the changes of insulin sensitivity in the liver and peripheral tissues of type 2 diabetic rats at different times after RYGB and to preliminarily explore the possible mechanism...

2024-06-26
【Animal modeling】-Effect of natural enemy sound stress on anxiety-like behavior in SD rats

【Animal modeling】-Effect of natural enemy sound stress on anxiety-like behavior in SD rats

To observe the effects of natural enemy sounds on anxiety-like behaviors of SD rats under different durations and repeated stress...

2024-06-26
[Animal modeling] - Study on the safety and effectiveness of human umbilical cord mesenchymal stem cells in the treatment of acute lung injury in mice

[Animal modeling] - Study on the safety and effectiveness of human umbilical cord mesenchymal stem cells in the treatment of acute lung injury in mice

To investigate the safety and efficacy of human umbilical cord mesenchymal stem cells (HUC MSCs) in the treatment of lipopolysaccharide (LPS) - induced acute lung injury in mice...

2024-06-26
【Animal Modeling】-Hydrogen-rich liquid attenuates cerebral ischemia-reperfusion injury in rats through PI3K pathway

【Animal Modeling】-Hydrogen-rich liquid attenuates cerebral ischemia-reperfusion injury in rats through PI3K pathway

To investigate the effect of hydrogen-rich solution on the apoptosis of hippocampal neurons and the expression of PI3K/Akt/FoxO1 signaling pathway induced by cerebral ischemia-reperfusion in rats...

2024-06-24
[Animal modeling] - The role of villin 1 in the model of unilateral nephrectomy Habu nephritis in mice

[Animal modeling] - The role of villin 1 in the model of unilateral nephrectomy Habu nephritis in mice

To investigate the similarities and differences between unilateral nephrectomy (UNX) mouse Habu nephritis model and normal mouse Habu nephritis model in renal function, renal pathology and expression of glomerular villin 1 (VIL 1) and their molecular...

2024-06-24
[Animal Modeling - Pharmacodynamic Evaluation] - Spontaneous Vitiligo Animal Model

[Animal Modeling - Pharmacodynamic Evaluation] - Spontaneous Vitiligo Animal Model

Humans can induce local depigmentation in some animals, such as chickens, rodents, dogs, cats, and horses. These animals often have anti melanocyte antibodies in their bodies, with the most commonly used being Smyth line (SL) chickens and C57BL mice...

2024-06-19
【Animal modeling 】- Pharmacodynamic evaluation - Homologous/xenograft squamous cell carcinoma model

【Animal modeling 】- Pharmacodynamic evaluation - Homologous/xenograft squamous cell carcinoma model

Inoculating human SCC tissue or cancer cells into the back, forelimb armpits, inguinal area, lateral chest wall, or sublingual area of immunodeficient mice can produce SCC locally...

2024-06-19