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【Animal modeling】-Propofol protects against cerebral ischemia-reperfusion injury and may be related to the inhibition of gap junction function

【Animal modeling】-Propofol protects against cerebral ischemia-reperfusion injury and may be related to the inhibition of gap junction function

To investigate the relationship between the protective effect of propofol on cerebral ischemia-reperfusion injury and gap junctions and its possible mechanism...

2024-07-01
【Animal Modeling】-Screening of microsatellite loci for genetic analysis of experimental cat population

【Animal Modeling】-Screening of microsatellite loci for genetic analysis of experimental cat population

To screen for microsatellite loci suitable for the detection of cat genetic quality...

2024-07-01
[Animal modeling - Pharmacodynamic evaluation] - Swine heart failure model induced by rapid right ventricular pacing

[Animal modeling - Pharmacodynamic evaluation] - Swine heart failure model induced by rapid right ventricular pacing

Intravenous injection of ketamine 10mg/kg, atropine 0.5mg, and diazepam 1.0mg/kg. After successful anesthesia, lie on your back and establish a venous access. Open the brachiocephalic vein and insert the endocardial pacing electrode into the right ve...

2024-07-01
[Animal Modeling - Pharmacodynamic Evaluation] - High fat Feed Induced Hyperlipidemia Animal Model in Rabbits

[Animal Modeling - Pharmacodynamic Evaluation] - High fat Feed Induced Hyperlipidemia Animal Model in Rabbits

Feeding animals with high-fat and high cholesterol feed can cause hyperlipidemia in the short term...

2024-07-01
【 Animal Modeling Pharmacodynamic Evaluation 】 - Non feeding induced hyperlipidemia animal model in mice

【 Animal Modeling Pharmacodynamic Evaluation 】 - Non feeding induced hyperlipidemia animal model in mice

Administer Triton WR-1339 intravenously or intraperitoneally, with intravenous injection of 400mg/kg once...

2024-07-01
Animal Modeling Pharmacodynamic Evaluation Experimental Renal Artery Stenosis Hypertension Model

Animal Modeling Pharmacodynamic Evaluation Experimental Renal Artery Stenosis Hypertension Model

After anesthesia, the animal is placed in an abdominal position, starting from 1.5-2cm beside the spine, along the rib edge on the right side, and making a 4cm skin incision on the left side about two fingers wide at the rib edge. The subcutaneous ti...

2024-07-01
[Animal modeling - Pharmacodynamic evaluation] - Sucrose induced hypertensive rat model

[Animal modeling - Pharmacodynamic evaluation] - Sucrose induced hypertensive rat model

Due to high sugar intake, SD rats can develop insulin resistance and hyperinsulinemia, leading to an increase in blood pressure. The possible mechanism of the latter is: ① insulin induced sodium water retention; ② Stimulating sympathetic nervous syst...

2024-07-01
[Animal Modeling - Pharmacodynamic Evaluation] - Rabbit Brain Edema Model Induced by Typhoid Lipopolysaccharides

[Animal Modeling - Pharmacodynamic Evaluation] - Rabbit Brain Edema Model Induced by Typhoid Lipopolysaccharides

After animal anesthesia, the common carotid artery is surgically separated and a right ventricular catheter is inserted. A brain pressure gauge is connected to measure ventricular pressure, and an amplifier can also be connected to monitor intracrani...

2024-07-01
[Animal Modeling - Pharmacodynamic Evaluation] - Pertussis Bacterial Liquid Induced Brain Edema Model in Rabbits

[Animal Modeling - Pharmacodynamic Evaluation] - Pertussis Bacterial Liquid Induced Brain Edema Model in Rabbits

After anesthesia, the animal is placed in a supine position and a 5cm incision is made at the midline of the neck to expose the right common carotid artery, separate the internal carotid artery, ligate the collateral branch that did not enter the sku...

2024-07-01
[Animal Modeling Pharmacodynamic Evaluation] - Traumatic Brain Edema Model in Rats

[Animal Modeling Pharmacodynamic Evaluation] - Traumatic Brain Edema Model in Rats

The animal in the modeling group underwent surgery to expose the left parietal bone. A bone hole with a diameter of 5.0mm was drilled along the midline of the sagittal suture and 1.5mm behind the coronal suture, exposing the dura mater. The lower end...

2024-07-01
[Animal Modeling - Pharmacodynamic Evaluation] - Rabbit Lung Candida albicans Infection Model

[Animal Modeling - Pharmacodynamic Evaluation] - Rabbit Lung Candida albicans Infection Model

36 New Zealand white rabbits with large ears, 18 in the experimental group and 18 in the control group. On the 1st to 5th day of the experiment, daily intravenous injection of 440mg/m2 of cytarabine was administered to the ear margin, and immunosuppr...

2024-07-01
[Animal modeling - Pharmacodynamic evaluation] - Chemical induced cardiogenic shock

[Animal modeling - Pharmacodynamic evaluation] - Chemical induced cardiogenic shock

Cats can be used as a cardiogenic shock model when their blood pressure drops below half of the normal value due to slow femoral vein injection of 3% pentobarbital under the anesthesia and artificial respiration conditions of Ultan...

2024-07-01
[Animal Modeling Pharmacodynamic Evaluation] - Rat Pulmonary Aspergillus Infection Model

[Animal Modeling Pharmacodynamic Evaluation] - Rat Pulmonary Aspergillus Infection Model

Adult SD rats were instilled with Aspergillus fumigatus suspension through tracheal intubation to establish a rat lung infection model. The suspension of Aspergillus fumigatus was inoculated into the rats through nasal and oropharyngeal instillation ...

2024-07-01
Animal modeling drug efficacy evaluation stroke sequelae model

Animal modeling drug efficacy evaluation stroke sequelae model

12 week old male Wistar rats, weighing 250-300g; Medication: Anesthetics; Instruments: rat stereotactic device, miniature electrocoagulation knife, electric pulse random stimulation device...

2024-07-01
Animal modeling drug efficacy evaluation induced psoriasis animal model

Animal modeling drug efficacy evaluation induced psoriasis animal model

This model is commonly used in China. Huang et al. applied 5% propranolol to the ear of guinea pigs (350-400g) and 0.3g of the drug (1cm2) twice a day for 2 consecutive weeks. At the same time, 1% dinitrochlorobenzene (DNCB) and 1% croton oil castor ...

2024-07-01
[Animal Modeling - Pharmacodynamic Evaluation] - Repeated Immune Induction of Ulcerative Colitis in Rats

[Animal Modeling - Pharmacodynamic Evaluation] - Repeated Immune Induction of Ulcerative Colitis in Rats

Adult rats, regardless of gender, weighing 250-400g; Medications: physiological saline, formaldehyde...

2024-07-01