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[Animal Modeling - Pharmacodynamic Evaluation] - Animal Model of Lung Qi Deficiency Syndrome by Comprehensive Stimulation of Wind Cold and Sulfur Dioxide

[Animal Modeling - Pharmacodynamic Evaluation] - Animal Model of Lung Qi Deficiency Syndrome by Comprehensive Stimulation of Wind Cold and Sulfur Dioxide

Adult rats were stimulated with sulfur dioxide at a dose of (200-250) x 10 to the power of -5, for 1 hour per day and continuous stimulation for 13 days. Cold wind stimulation was used with a temperature 5 ℃ lower than the living environment temperat...

2024-07-01
[Animal Modeling - Pharmacodynamic Evaluation]- Guinea Pig Ulcerative Colitis

[Animal Modeling - Pharmacodynamic Evaluation]- Guinea Pig Ulcerative Colitis

Put 20-50g/L of degraded carrageenan solution into a bottle for guinea pigs to drink, record the amount of water the guinea pigs drink, and add sucrose at a rate of 50g/L to increase palatability...

2024-07-01
[Animal modeling - Pharmacodynamic evaluation] - Severe combined immunodeficiency mouse chronic colitis model

[Animal modeling - Pharmacodynamic evaluation] - Severe combined immunodeficiency mouse chronic colitis model

Female BALB/c mice (H-2 gene phenotype), aged 8-10 weeks at the time of use; Reagents and antibodies: Hamster anti mouse CD3 monoclonal antibody, fluorescein isothiocyanate (FITC) labeled anti mouse CD45RB monoclonal antibody, phycoerythrin (PE) labe...

2024-07-01
[Animal Modeling Pharmacodynamic Evaluation] - Pig Pancreaticoduodenal Transplantation Model

[Animal Modeling Pharmacodynamic Evaluation] - Pig Pancreaticoduodenal Transplantation Model

Closed group small pigs, weighing 15.5-43.0kg, 2-3 months old, with similar body weights for both donors and recipients, regardless of gender. They were fasted for 24 and 6 hours before surgery, and water was prohibited. They were randomly divided in...

2024-07-01
[Animal Modeling - Pharmacodynamic Evaluation] - Animal Model of Traumatic Stasis Syndrome

[Animal Modeling - Pharmacodynamic Evaluation] - Animal Model of Traumatic Stasis Syndrome

Adult rabbits were fixed on a rabbit platform, and a lever pressure device was used to apply 7.5kg of pressure on the inner thigh muscle of the right hind limb for 1.5 hours. The changes in muscle temperature, leg diameter, hind limb blood flow, conj...

2024-07-01
Animal Modeling Pharmacodynamic Evaluation Immunological Chronic Liver Injury Model

Animal Modeling Pharmacodynamic Evaluation Immunological Chronic Liver Injury Model

Prepare a BCG vaccine solution with physiological saline to contain 10 times the power of live bacteria per milliliter, and inject 0.2ml (2.5mg) of BCG vaccine solution through the tail vein. 10 days later, 0.2ml (10 μ g) of LPS physiological saline ...

2024-07-01
[Animal modeling - Pharmacodynamic evaluation] - Chronic liver injury model induced by sucrose and alcohol

[Animal modeling - Pharmacodynamic evaluation] - Chronic liver injury model induced by sucrose and alcohol

For the first 3 days, rats were given a 2% sucrose solution for free consumption. Then, 5% alcohol was added to the sucrose solution, and the alcohol concentration was increased by 5% to 15% every 4 days. Afterwards, the alcohol concentration was inc...

2024-07-01
[Animal Modeling Pharmacodynamic Evaluation ]- Animal Model of Congenital Kidney Yang Deficiency Syndrome

[Animal Modeling Pharmacodynamic Evaluation ]- Animal Model of Congenital Kidney Yang Deficiency Syndrome

Adult mice, good at calling ferocious cats. When raising mice to the age of 75 days, they were mated in a ratio of 2:1 male and female. On the evening of the 4th day, male mice were taken out, and on the 5th day, the experimental mice were intimidate...

2024-07-01
[Animal Modeling Pharmacodynamic Evaluation] - Elderly Kidney Yang Deficiency Animal Model

[Animal Modeling Pharmacodynamic Evaluation] - Elderly Kidney Yang Deficiency Animal Model

The content of 3 β - HSD and glucose-6-phosphate dehydrogenase (G-6-PD) in the interstitial cells of the testes of elderly animals, as well as the content of 3 β - HSD in the adrenal cortex, significantly decreased...

2024-07-01
[Animal modeling - Pharmacodynamic evaluation] - Chronic liver injury model induced by total nutrients and alcohol

[Animal modeling - Pharmacodynamic evaluation] - Chronic liver injury model induced by total nutrients and alcohol

Feed rats with liquid feed containing total nutrients and alcohol. This food is formulated based on calories, with 21% fat, 18% protein, 47% carbohydrates (36% of which are replaced by alcohol), as well as some vitamins and inorganic salts. Solid foo...

2024-07-01
[Animal Modeling Pharmacodynamic Evaluation] - Pyrazole Plus Wine Refined Chronic Liver Injury Model

[Animal Modeling Pharmacodynamic Evaluation] - Pyrazole Plus Wine Refined Chronic Liver Injury Model

Rats were fed liquid feed containing total nutrients and alcohol with pyrazole for 12 weeks...

2024-07-01
Animal modeling drug efficacy evaluation - tetracycline induced acute liver injury model in mice

Animal modeling drug efficacy evaluation - tetracycline induced acute liver injury model in mice

The tetracycline modeling group was prepared into a suspension at a dose of 2250mg/kg, administered orally once at a weight of 0.2ml/10g, and the model was formed after 18 hours; The blank control group was given an equal volume of physiological sali...

2024-07-01
[Animal modeling - Pharmacodynamic evaluation] - Alcohol induced acute liver injury model

[Animal modeling - Pharmacodynamic evaluation] - Alcohol induced acute liver injury model

Use 56 degree Baijiu, intraperitoneal injection, rats 7ml/kg body weight each time (mice 16ml/kg body weight each time), twice a day, for 2 weeks...

2024-07-01
[Animal modeling - Pharmacodynamic evaluation] - A model of acute liver injury induced by concanavalin A

[Animal modeling - Pharmacodynamic evaluation] - A model of acute liver injury induced by concanavalin A

Cona bean protein A can activate the proliferation of CD8+or CD4+cells, increase the release of IFN - γ, which promotes the infiltration of inflammatory cells into the hepatic portal vein area and activates the comprehensive response of M phi functio...

2024-07-01
[Animal Modeling Pharmacodynamic Evaluation ]-Thyroidectomy Animal Model of Kidney Yang Deficiency Syndrome

[Animal Modeling Pharmacodynamic Evaluation ]-Thyroidectomy Animal Model of Kidney Yang Deficiency Syndrome

Adult rats were anesthetized, with skin incision, muscle dissection, bilateral thyroid separation and excision, and muscle and skin suturing. Observe the general condition of rats, test left ventricular function and thyroid function, euthanize animal...

2024-07-01
Animal Modeling Pharmacodynamic Evaluation Sex Hormone Application Method Animal Model of Kidney Yang Deficiency Syndrome

Animal Modeling Pharmacodynamic Evaluation Sex Hormone Application Method Animal Model of Kidney Yang Deficiency Syndrome

Select female rat offspring born at the same time period for selective breeding. On the 8th day of age, female rats were subcutaneously injected with testosterone propionate at a dose of 1.25mg/animal in the neck and back, and weaned on the 22nd day ...

2024-07-01